DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alt and Cgn

DIOPT Version :9

Sequence 1:	NP_001262679.1	Gene:	alt / 42127	FlyBaseID:	FBgn0038535	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	XP_006232989.1	Gene:	Cgn / 310655	RGDID:	1311992	Length:	1197	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	205/983 - (20%)
Similarity:	382/983 - (38%)	Gaps:	249/983 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KKKELKREKKQRQREQ------QRDVNNEPEPEEAEDYSDG------------------------ 93
            :.|.|.:| :||:|.|      .||...:.|.:....::.|
  Rat   195 RTKTLPQE-QQRKRSQSLDSRLSRDTREDRELQSTNHWARGTKYDNHMDSSKTLPQKQSPFSSFS 258

  Fly    94 ----------QSEGQGSVAGEEPGLSKQHVEFEPDAEVLTDQRR---PSSVAEKENQPSGAGKKG 145
                      ||..:.....::|.:    |:|:...::|.|||.   |.|....:....|..::|
  Rat   259 RSRQTQDWVLQSFEESREKVQDPAM----VQFKSTPDLLRDQREAAPPGSADHMKATIYGILREG 319

  Fly   146 KKDKRNGANNKTAGILVNKNETVAVKPAA------NAEETPTLNNFETKIPKDVVELKKQE---- 200
            ..|.......|.:.:|........|.||:      .||.|..:...:.|:.::|.:.:|.|
  Rat   320 SADSEASVRRKVSLVLEQMQPLGMVSPASTKALVGQAELTRKMEELQKKLDEEVKKRQKLEPSRI 384

  Fly   201 ----QKERKEDNNNKQQSQKKIAGGNVSKKEKVVAVETEAPVVTKQILKQQQQQQNGSPKTQHNQ 261
                |.|.|.:..::.|...:...|.|.:..|.:.       ..|.:|.|::..::|. :||..:
  Rat   385 GLERQLEEKAEECHRLQELLEKRKGEVQQSAKELQ-------NMKLLLGQEEGLRHGL-ETQVKE 441

  Fly   262 ANNKTKQQQQ---NKKQNQKETLTGKDLAHALDKLADHQNQTIGVNALMNVFSRAELNRSEIQIL 323
            ...|.|..|.   .|:...|:.|..::|   |::|.:.:.:         |..:..|...|:..|
  Rat   442 LQLKLKHSQNLDPGKESLLKDLLETREL---LEELLEGKQR---------VEEQLRLRERELTAL 494

  Fly   324 IDYLLNKQQDMPASHSEWSDDICQKLKRQLEEKEKLLAEEQEASIGIQAK-------LRELRQEV 381
            ...|    ::..|||.:..:.:..:.:|..|:..:.:.:..:....::|:       :|||::|:
  Rat   495 KGAL----KEEVASHDQEVEHVRLQYQRDTEQLRRSMQDATQDHAAVEAERQKMSSLVRELQKEL 555

  Fly   382 -NTERAQMHARN--QAYIDKLQGKEQELAALNQELSSLNDKLTLERQQLTTLRREKQANSQDLVQ 443
             .|.....|.:|  |...::|:..:|||..|..|...:.::|..:.:.|.....:.:|:::|..|
  Rat   556 EETSEETGHWQNMFQKNKEELRAAKQELLQLRMEKEEIEEELGEKMEILQRDLEQARASTRDTQQ 620

  Fly   444 LQHLQQDLAHKEKCLAEMTAFVNAETQQ-----KNEVIQQQAQQLQALELQREELEARQNNSIFE 503
            ::.|:::|...:..|.|:.|  ..::|:     :|:|:::|...|:|                 |
  Rat   621 VEELKKELQRTQGELKELQA--ERQSQEVAGRHRNQVLEKQLSVLRA-----------------E 666

  Fly   504 LEQRKQLEAENADLKQELSAVQQTQSELQRVHAAE-----------------LQELRQNLSVLEA 551
            .::.:.||.:|..|::.|..::|...|..:...|.                 |:|.::.......
  Rat   667 ADRSRDLEEQNLQLQKTLQQLRQDCEEASKAKVASETEAMVLGQRQATVETTLRETQEENDEFRR 731

  Fly   552 RNVALSQQLTQA-----ANSAVQATAAQS-EQAQVQTEALAQKQQELSALRSQVGSLTDAHAQQQ 610
            |.:.|.|||.:|     ...||:|..... .:.:|:.:   |.::.|:..:.:.|||..|
  Rat   732 RILGLEQQLKEARGLVEGGEAVEARLRDKVHRLEVEKQ---QLEEALNVAQEEEGSLAAA----- 788

  Fly   611 KQANALQSQLQEAQQRAEQLQAKEQHLQQELQEQREKNNDVRMKNWKLIEALQNAEALTAKTKTN 675
              ..||:.:|:|||:...:|..::|.|.:.|:|:.::.           |||:.::|...:.|..
  Rat   789 --KRALEIRLEEAQRGLARLGQEQQALNRALEEEGKQR-----------EALRKSKAELEEQKRL 840

  Fly   676 SAQSVGQQHKEL------------QLQQQ---------KAVA--------------ANGGGSASS 705
            ..::|.:.:|||            |||.|         |.||              .|.|| .|.
  Rat   841 LNRTVDRLNKELEQIGDDSKLALQQLQSQMEDYKEKARKEVADAQRQAKDWASEAEKNSGG-LSR 904

  Fly   706 AKSEQQRIRDLYQRLYPDAVKAQSGNALQASFDQWLEQVLATHVKQQQDKLRQ---------KLD 761
            .:.|.||:|...|....:...|:....|.|...|.|||......:.|.||.||         :|:
  Rat   905 LQDELQRLRQALQTSQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDKARQLKSLEEKVSRLE 969

  Fly   762 AEKSEK--------------------------QSSSSHKSTQSSNSSSSNHNSTHNNISSNNSSS 800
            ||..|:                          |..|:.:..:....|....|   .::.:..:||
  Rat   970 AELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN---KDLKTRLASS 1031

  Fly   801 NSQSSSAAEQQELHKQN--LQLRECNDKLTQLVTKTTNTLMDLEERAREQ----DEHWRGIVEQK 859
            ......:|...:|..||  ||.|...::..:.|.::||  ..||.|.:|.    |:..:.:.:||
  Rat  1032 EGLQKPSASFSQLESQNQLLQERLQAEEREKTVLQSTN--RKLERRVKELSIQIDDERQHVNDQK 1094

  Fly   860 EQLILTLQ 867
            :||.|.::
  Rat  1095 DQLTLRVK 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alt	NP_001262679.1	SMC_prok_B	<398..694	CDD:274008	73/344 (21%)
Cgn	XP_006232989.1	Myosin_tail_1	362..1146	CDD:279860	172/811 (21%)
		RILP-like	<1017..1118	CDD:304877	23/91 (25%)
		Tho2	1084..>1165	CDD:288156	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000