DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mps1 and PPK1

DIOPT Version :9

Sequence 1:	NP_001262677.1	Gene:	Mps1 / 42126	FlyBaseID:	FBgn0000063	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_565160.3	Gene:	PPK1 / 844108	AraportID:	AT1G77720	Length:	777	Species:	Arabidopsis thaliana

Alignment Length:	761	Identity:	195/761 - (25%)
Similarity:	297/761 - (39%)	Gaps:	172/761 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTPVPRRTKDMMALG-------LDSDSEDDFNTPYRPRQAAAGERKQ--QPVAS--FQVQTR-- 52
            :.|...:|::|::.|.       |..|:.::...     .:.|||...  ||..|  |....|
plant    81 LVTAEGQRSQDVVTLSQSLAANTLTQDTTNNLAI-----TSVAGESASITQPTVSEHFNPSDRQM 140

  Fly    53 --GKENEPHPLPINMLPRRVSELTMMDSDSDEED----IKSNHNLNCAILNDSFVLSPSQELTNS 111
              || :....|..|:..:|.|:..:..|...|.|    .:::|       .|:.:.|..|.|.:.
plant   141 DFGK-SAVTSLESNLDVQRKSQSLIGTSQDMEWDATNQAEASH-------LDACIGSKHQNLPSV 197

  Fly   112 NSNITTRRTPSAAPLKQSDSNLSF---LGRF----NDMGINCSSQGSPVANSEKQVAKKTAPTLQ 169
            :|.::.:     :..|.|.|....   ||.|    |.....||:.||..|.: ..:...:||.|.
plant   198 DSEVSLK-----SEYKDSSSLAKIQGQLGEFPNFLNQPRTRCSAVGSSWATT-TLIHSSSAPMLN 256

  Fly   170 AAPSATERRPLQETETPLRNELPSTSKTKPDADFITPQVRTIGSTLAGKSRSAVSNDFRAQKVLF 234
            |....:            |:.:.:.|...|.|      |::.|:..:....|.|||.....|...
plant   257 ATTHVS------------RSYVEADSNANPHA------VQSQGNLPSCCPSSKVSNILHPNKDAT 303

  Fly   235 QTPMTVSRAAP-VASDSISFSLCDTITESPDIP--------EPPKKAEPPKSQHPSKKSLDHVFR 290
            .:.|..|...| |.......|....||...:.|        :....|..|:..|.|..|
plant   304 ASEMPASTNDPEVRVKETDTSKQQQITTGLEAPVGSSIYGSDGQANARLPEELHTSVSS------ 362

  Fly   291 ESDKDNVPDKVDNVEPKELVSIPAVAVPPEQPSHKTSNILKIKNHEYTIDKKLGCGGSSSVFLAR 355
                  .|.|.|..|.......|:.   |.:.::......|:....|....|:|.||||.|....
plant   363 ------QPQKSDKHEKVASSKGPSA---PRKRNYDPDLFFKVNGKLYQRLGKIGSGGSSEVHKVI 418

  Fly   356 RSDSGNEFALKVVDLQA-DPQVVQGYLNETKLLAKLQGNVCVVALYDYQL--------------- 404
            .||. ..:|||.:.|:. |.....|:..|...|.||:|...::.|.||::
plant   419 SSDC-TIYALKKIKLKGRDYATAYGFCQEIGYLKKLKGKTNIIQLIDYEVTDKTLLQEVLNGTMS 482

  Fly   405 -----VREESKLYMVMEKGDCDLNKIL-------QSYTTNLPLYSLMNILYQMLQAVNYIHQHGV 457
                 |:|:..:|||:|.|:.||..:|       :.....:....|.....|:|||||.||:..:
plant   483 NKDGRVKEDGFIYMVLEYGEIDLAHMLSQKWREIEGSDRTIDENWLRFYWQQILQAVNTIHEERI 547

  Fly   458 IHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSIIKFSQAGTFNYISPEAL---TDTSTGNSPM 519
            :||||||||||:|.|.|||||||||..|..|:|:|.:.||.||.:|:||||.   .....||:
plant   548 VHSDLKPANFLLVRGFLKLIDFGIAKAINSDTTNIQRDSQVGTLSYMSPEAFMCNESDENGNT-- 610

  Fly   520 RRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHIRNVYAKMSAITTPGTSIEY---------- 574
                   ||....||:||||||||.::|.:|||...:..:||...||.|...|.|
plant   611 -------IKCGRPSDIWSLGCILYQMVYGRTPFADYKTFWAKFKVITDPNHEITYNQLSNPWLID 668

  Fly   575 --------------------------PAIP--PYYPIMLVHFTTVSALFADGQELPTVESQKAAV 611
                                      |.||  |....:.:......:..:|..:..::.||...:
plant   669 LMKKCLAWDRNQRWRIPELLQHPFLAPPIPHEPQVKTIKLFSLIAESCGSDDDKANSMISQLEQL 733

  Fly   612 VHRTTTVPIPYDHSAAEPADTQQNRQQQLSTKAQLFISEMSKVKCL 657
            :  :...|:|.:    :..|::...||.||..::|.|....:::.|
plant   734 L--SNPAPLPRN----DVLDSRDQNQQLLSRVSELCIQLQDRLQGL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	105/312 (34%)
Mps1	NP_001262677.1	S_TKc	337..575	CDD:214567	102/304 (34%)
PPK1	NP_565160.3	PKc_Mps1	398..693	CDD:271033	102/304 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	140	1.000	Domainoid score	I1530
eggNOG	1	0.900	-	-		E1_KOG0596
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005632
OrthoInspector	1	1.000	-	-		oto2928
orthoMCL	1	0.900	-	-		OOG6_103440
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4035
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.770