Protein Alignment Mps1 and ttk

DIOPT Version :10

• Sequence 1: NP_001262677.1
• Gene: Mps1 / 42126
• FlyBaseID: FBgn0000063
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: XP_012818613.1
• Gene: ttk / 780054
• XenbaseID: XB-GENE-953775
• Length: 879
• Species: Xenopus tropicalis
• Alignment Length: 705
• Identity: 210/705 - (29%)
• Similarity: 298/705 - (42%)
• Gaps: 176/705 - (24%)

  Fly     8 RTKDMMALGLDSDSEDDF-------------NTPYRPRQAAAGERKQQPVASFQVQTRGKENEPH 59
            |..::.|:....::.|.|             :|.:...:.:.|..|:    ..|:..||.  |..
 Frog   116 RFAELKAIHDPDEARDQFQLARLNCKKFAFVHTAFAQFELSEGNFKK----CKQILRRGL--ECG 174

  Fly    60 PLPINMLPRRVSELTMMDSDSDEEDIKSNHNLNCAILNDSFVLSPSQELTNSNSNITTRRTPSAA 124
            .||..||...:..|.:..:....|:.|.|..::.:.:|..  ::..|.|...|.......:|...
 Frog   175 ALPCEMLNLALKNLQLKKTQLISEEDKENLAVSSSQINQG--MAGYQNLALGNPQRMKNESPEEY 237

  Fly   125 PLKQSDS---NLSFLGRFNDMG----INCSSQGSPVANSEKQVAKKTAPTLQ------AAPSATE 176
            .:|...|   .||....|.|:|    :|..::..|:  ....|...|:|.::      :..|:..
 Frog   238 SVKTRFSYGEKLSSPEDFEDIGRKPLLNMPAKSCPL--GRVPVQPTTSPDMRTRKSDGSGSSSVV 300

  Fly   177 RRPLQETETPLRNELPS----------------TSKTKP---------DADFITPQVRTIG---S 213
            ::|......|:...||.                .|:|.|         ..|..||....:.   |
 Frog   301 KKPPSSMRVPVLAALPKPKYLGDDLHCSEDIKLPSRTSPSHEEQANEDSLDIKTPSSVLLSGTES 365

  Fly   214 TLAGK-----------SRSAVSNDFRAQKVLFQTPMTVSRAAPVASDSISFSLCDTITESPD--- 264
            ||..|           |.:||.|....:|        .|:.||....:|:..|.|  |..|:
 Frog   366 TLTVKRNEDIIMEDKDSSTAVLNHQENRK--------PSKPAPPPIPNINARLSD--TTKPNNIE 420

  Fly   265 ------IPEPP---------------------KKAEPPKSQHPSKKSLDHVF--------RESDK 294
                  :||.|                     ::|.||.   ||.:..|.||        .:.|.
 Frog   421 AEWKWKVPETPRHIFQPECKRKSIEPCANPGSRRASPPA---PSIRKCDPVFVCGTPVNKMQEDY 482

  Fly   295 DN---VPDKVDNVEPKELVSIPAV--------AVPPEQPS-------HKTSNILKIKNHEYTIDK 341
            .|   .|....|:.|...:|.|..        ..|..||.       ..:|:.:.:|...|.:.|
 Frog   483 MNCFRTPVVKTNLGPLAQMSTPCTNRLDYQHPQTPIVQPGCFPISAPLASSDCIVVKGRVYAVLK 547

  Fly   342 KLGCGGSSSVFLARRSDSGNEFALKVVDLQ-ADPQVVQGYLNETKLLAKLQGNV-CVVALYDYQL 404
            ::|.||||.||.. ..|..:.:|:|.|:|| ||.|.::.|.||...|.|||.:. .::.||||::
 Frog   548 QIGTGGSSKVFQV-MDDKKHLYAIKYVNLQEADQQTIESYQNEISHLNKLQQHSDKIIRLYDYEI 611

  Fly   405 VREESKLYMVMEKGDCDLNKIL-----------QSYTTNLPLYSLMNILYQMLQAVNYIHQHGVI 458
            .  :..:|||||.|:.|||..|           :||..|            ||:||:.|||||::
 Frog   612 T--DQHIYMVMECGNIDLNTWLRKKKAINPWERKSYWKN------------MLEAVHTIHQHGIV 662

  Fly   459 HSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSIIKFSQAGTFNYISPEALTDTSTGNSPMRRAD 523
            ||||||||||:|.|.|||||||||:.|..|.|||:|.||.||.||:.|||:.||:|    .....
 Frog   663 HSDLKPANFLIVDGMLKLIDFGIANQIQPDVTSIVKDSQVGTINYMPPEAIKDTTT----YAENG 723

  Fly   524 QPKIKISTKSDVWSLGCILYLLLYQKTPFGHIRNVYAKMSAITTPGTSIEYPAIP 578
            :|:.|||.|.||||||||||.:.|.||||.||.|...|:.||..||..||:|.||
 Frog   724 KPRSKISPKGDVWSLGCILYCMTYGKTPFQHITNQITKLHAILDPGYEIEFPNIP 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	123/257 (48%)
ttk	XP_012818613.1	PKc_Mps1	541..809	CDD:271033	123/257 (48%)