DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mps1 and ttk

DIOPT Version :9

Sequence 1:	NP_001262677.1	Gene:	Mps1 / 42126	FlyBaseID:	FBgn0000063	Length:	672	Species:	Drosophila melanogaster
Sequence 2:	NP_778207.1	Gene:	ttk / 317763	ZFINID:	ZDB-GENE-030123-1	Length:	983	Species:	Danio rerio

Alignment Length:	747	Identity:	212/747 - (28%)
Similarity:	328/747 - (43%)	Gaps:	146/747 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DSDSEDDFNTPYRPRQAAAGERKQQPVASFQVQTRGKENEP--HPLPINMLPRRVSELTMMDSDS 80
            |||.......|:......:.:.....|.|.......|:..|  ....:|:.|..:|      .|.
Zfish   259 DSDCAQKAEAPFTHSSGFSRQTSGSSVRSAFSLCSSKKGTPDGDSYSLNIKPPVIS------PDY 317

  Fly    81 DEEDIKSNHNLNCAILN--DSFVLSPSQELTNSNSNITTRRTPSAAPL-----KQSD--SNLSFL 136
            ..|||:..|.:. |:||  :....:.::|.|:.|..|:|..|......     |::|  |:.:||
Zfish   318 LREDIEEGHTIT-ALLNRAEKRETARTEETTDINQIISTNSTEGCQAFLKNLEKRADPHSDAAFL 381

  Fly   137 GRFND----------MGINCSSQG---------------SP---------------------VAN 155
            .:..|          :..:|.::.               .|                     :|:
Zfish   382 SKLLDCYSKVFARFPLAEHCKTESYARMLVRYAELKGIEDPEDAADDFSIARSHCKAFAFVHIAH 446

  Fly   156 SEKQV----AKKTAPTLQAAPSATERRPLQETETPLRN-------ELPSTSKTKPDADFITPQ-- 207
            ::.::    ::|:...||.|.| :..||::..:|.:||       .||:..:...:|:.:..|
Zfish   447 AQFELSRGNSRKSVSILQKALS-SNARPIELLQTAIRNLKSGKTLLLPADLQESSEAENVEAQNY 510

  Fly   208 -VRTIGSTLAGKSR-----SAVSNDFRAQKVLFQTPMTVSRAA---PVASDSISFSLCDTITESP 263
             .|...|..|.:..     ...|::::...::.:......|.|   ||:|.|...::   .|.:|
Zfish   511 IKREENSAKAPEDHQKPFSKETSSEWKIPALITKHTSPEDRKASLEPVSSSSSHHAV---RTPAP 572

  Fly   264 DIPEPPKKAEPPKSQHPSKKS-LDHVFRESDK-DNVPDKVDNVEPKELVSIPAVAV----PPEQ- 321
            ....|....:.|..:.|:..| :..|.::... .:||.....:.|..|...|...|    ||.|
Zfish   573 LRLNPSLSCQTPNYRQPNPNSFVTPVVKQRPVIVSVPATAQKMCPTALPCTPQSGVSYIQPPTQT 637

  Fly   322 PSHKTSN-ILKIKNHEYTIDKKLGCGGSSSVFLARRSDSGNEFALKVVDL-QADPQVVQGYLNET 384
            ||...|| .:.||..::.|.|.:|.||||.|:.. .....:.:|:|.|:| :||.|.|:.|.||.
Zfish   638 PSSAFSNESITIKGKQFFIFKMIGRGGSSKVYQV-FDHKKHVYAVKYVNLEEADAQAVESYKNEI 701

  Fly   385 KLLAKLQG-NVCVVALYDYQLVREESKLYMVMEKGDCDLNKILQSYTTNLPLYSLMNILYQMLQA 448
            :.|..||. :..::.||||::.  .|.:||:||.|..|||..|::..|..|| ........||:|
Zfish   702 EHLNHLQQYSDQIIKLYDYEIT--SSYIYMLMECGHLDLNTWLRNRKTVKPL-DRKAYWRNMLEA 763

  Fly   449 VNYIHQHGVIHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSIIKFSQAGTFNYISPEALTDTS 513
            |:.||:||::||||||||||:|.|.|||||||||:.|..|.|||:|.||.||.||:.|||:.|||
Zfish   764 VHTIHKHGIVHSDLKPANFLIVDGSLKLIDFGIANQIQPDVTSIMKDSQVGTLNYMPPEAIKDTS 828

  Fly   514 TGNSPMRRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHIRNVYAKMSAITTPGTSIEYPAIP 578
            :..       :|..|||.|.||||||||||.:.|.||||.:|.|..:|:.||..|...|::|.||
Zfish   829 SNG-------KPGSKISAKGDVWSLGCILYCMTYGKTPFQNITNQISKIHAIIDPSHEIDFPDIP 886

  Fly   579 PYYPIMLVHFTTVSALFADGQELPTVESQKAAVV----HRTTTVPI---PY----DHSAAEPADT 632
                                 |...::..|..:|    .|.:...:   ||    ...|.|||:|
Zfish   887 ---------------------EKDLLDVLKKCLVRNPRERISIAELLDHPYLQLQPQPAPEPAET 930

  Fly   633 QQNRQQQLSTKAQLFISEMSKVKCLSH---MC 661
            ..:..:::..:.....|..|..:..|:   ||
Zfish   931 SSSDFKRILNELVALQSPNSIARAASNLAMMC 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	115/245 (47%)
Mps1	NP_001262677.1	S_TKc	337..575	CDD:214567	113/239 (47%)
ttk	NP_778207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..575		14/83 (17%)
		PKc_Mps1	652..917	CDD:271033	121/296 (41%)
		Pkinase	656..917	CDD:278497	121/292 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596660
Domainoid	1	1.000	177	1.000	Domainoid score	I3554
eggNOG	1	0.900	-	-		E1_KOG0596
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005632
OrthoInspector	1	1.000	-	-		oto39249
orthoMCL	1	0.900	-	-		OOG6_103440
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R740
SonicParanoid	1	1.000	-	-		X4035
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730