Protein Alignment Mps1 and Ttk

DIOPT Version :9

• Sequence 1: NP_001262677.1
• Gene: Mps1 / 42126
• FlyBaseID: FBgn0000063
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: XP_006243522.1
• Gene: Ttk / 315852
• RGDID: 1305558
• Length: 864
• Species: Rattus norvegicus
• Alignment Length: 712
• Identity: 196/712 - (27%)
• Similarity: 296/712 - (41%)
• Gaps: 209/712 - (29%)

  Fly     8 RTKDMMALGLDSDSEDDF-------------NTPYRPRQAAAGERKQQPVASFQVQTRGKENEPH 59
            |..::.|:....|:.|.|             :..:...:.:.|..|:..      |...|..|..
  Rat   122 RLAELKAIQEPDDAHDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSE------QLLHKAVETG 180

  Fly    60 PLPINMLPRRVSELTMMDSD-SDEEDIKSNHNLNCAILNDSFVLSPSQELTNSNSNITTRRTPSA 123
            .:|:.||...:..|.:.... ..|||.||        |:.|.||:..:..::|..|:.:|::
  Rat   181 AVPLQMLETAIRNLHLQKKQLLSEEDKKS--------LSASTVLTAQESFSSSLGNLQSRKS--- 234

  Fly   124 APLKQSDSNLSFLGRFNDMGINCSSQGSPVANSEKQVAKKTAPTLQAAPSAT---ERRPLQETET 185
                                 :|.                  |.:|||.:..   |..|.::.|.
  Rat   235 ---------------------SCD------------------PKVQAAAARILYGENMPPKDAEV 260

  Fly   186 PLRNELPSTSKTKPDADF--------ITPQ--VRTIGSTL-------------------AGKSRS 221
            ..||.|..|:|||....|        .:|.  |:|.||.:                   ..||..
  Rat   261 SHRNPLKQTNKTKRSCPFGRVPVNLLNSPDYYVKTDGSAVPQFTKRKISGSEYRDSIMPGSKSSG 325

  Fly   222 AVSNDFRAQKV-----LFQTPMTVSRAAPVASDSISF-SLCDTITESPDIPEPPKKAEP--PKSQ 278
            ..|.:.|..|.     |..:.::..:::.:.||.::. |..|:.....::.||..:.||  |:.:
  Rat   326 NDSYELRGLKPIQAIHLKDSLVSNEKSSELMSDLVTLKSKTDSSLTKLEVSEPKVRQEPEIPERR 390

  Fly   279 HPSKKS-------------------LDHVFRESDKD--------------------NVPDKVDNV 304
            |...:|                   :..|..::||:                    :||..:|
  Rat   391 HKQWQSARKPGCGIQNSAAFAPQWHVPDVTPKADKEQKCTTVEQLAFSVSKQSPPLSVPKWID-- 453

  Fly   305 EPKELVSIPAVA-----------------VPPEQPS------------HK--------------- 325
             ||.:...|:.:                 .||..||            |:
  Rat   454 -PKSVCETPSSSSLDDYMKCFKTSVVKNEFPPACPSSTPYSQLARHQQHQQQGLSTPLQNLQISG 517

  Fly   326 ---TSNILKIKNHEYTIDKKLGCGGSSSVFLARRSDSGNEFALKVVDLQ-ADPQVVQGYLNETKL 386
               .|..:.:....|:|.|::|.||||.||.. .::.....|:|.|:|: ||.|.:..|.||...
  Rat   518 SSSMSECISVNGRIYSILKQIGSGGSSKVFQV-LNEKKQINAIKYVNLEDADSQTIDSYRNEIAY 581

  Fly   387 LAKLQGNV-CVVALYDYQLVREESKLYMVMEKGDCDLNKILQSYTTNLPLYSLMNILYQMLQAVN 450
            |.|||.:. .::.||||::.  :..:|||||.|:.|||..|:...:..| :...:....||:||:
  Rat   582 LNKLQQHSDKIIRLYDYEIT--DRYIYMVMECGNIDLNSWLKKKKSINP-WERKSYWKNMLEAVH 643

  Fly   451 YIHQHGVIHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSIIKFSQAGTFNYISPEALTDTSTG 515
            .|||||::||||||||||:|.|.|||||||||:.:..|:|||:|.||.||.||::|||:.|.|:.
  Rat   644 TIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMAPEAIRDMSSS 708

  Fly   516 NSPMRRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHIRNVYAKMSAITTPGTSIEYPAI 577
                |...:.|.|||.:|||||||||||.:.|.||||.||.|..:|:.||..|...||:|.|
  Rat   709 ----RENGKIKTKISPRSDVWSLGCILYYMTYGKTPFQHIINQVSKLHAIIDPSHEIEFPEI 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	117/245 (48%)
		S_TKc	337..575	CDD:214567	115/239 (48%)
Ttk	XP_006243522.1	PKc_Mps1	530..798	CDD:271033	117/245 (48%)
		Pkinase	532..798	CDD:278497	117/243 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354370
Domainoid	1	1.000	186	1.000	Domainoid score	I3282
eggNOG	1	0.900	-	-		E1_KOG0596
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005632
OrthoInspector	1	1.000	-	-		oto98045
orthoMCL	1	0.900	-	-		OOG6_103440
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4035
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.740