Protein Alignment Mps1 and mph1

DIOPT Version :10

• Sequence 1: NP_001262677.1
• Gene: Mps1 / 42126
• FlyBaseID: FBgn0000063
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: NP_595150.2
• Gene: mph1 / 2540060
• PomBaseID: SPBC106.01
• Length: 678
• Species: Schizosaccharomyces pombe
• Alignment Length: 584
• Identity: 169/584 - (28%)
• Similarity: 260/584 - (44%)
• Gaps: 117/584 - (20%)

  Fly     8 RTK--DMMALGLDSDSEDDFNTPYRPRQAAAGERKQQPVASFQVQTRGKENEPHPLPINMLPRRV 70
            |||  |:...|..:.:..:.|||           ..|.:..|       |:...|||......
pombe    77 RTKNFDLQGNGGQNSALKEVNTP-----------AYQSMHHF-------EHLITPLPSTNASH-- 121

  Fly    71 SELTMMDSDSDEEDIKSN--HNLNCAILNDSFVLSPSQELTNSNSNITTRR---TPSAAPLKQSD 130
            ||:::   .:...|:.||  |:|          |..|...|..:.:|:.||   .....|.|:::
pombe   122 SEVSL---SAGVNDLNSNSEHDL----------LPKSVNKTPGSLSISRRRRIGRIGLGPPKRAE 173

  Fly   131 SNLSFLGRFNDMGINCSSQGSPVANSEKQVAKKTAPTLQAAPSATERRPLQETETPLRNELPSTS 195
            ..|:...:.:|      ::.|..|:.:.::..:.......:.:||..:|||...|||:     ||
pombe   174 YTLTDPSKTSD------TKNSTEADEDIEMKSREVSPASNSVAATTLKPLQLHNTPLQ-----TS 227

  Fly   196 KTKPDADFITPQVRTIGSTLAGKSRSAVSNDF-RAQKVLFQTPMTVSRAAPVASDSISFSLCDTI 259
            :..|...|...|..:..|     .|....:|. |....|...|:||
pombe   228 QEHPKPSFHPSQFESSFS-----PRVQFDHDVERRASELHSRPVTV------------------- 268

  Fly   260 TESPDIPEPPKKAEPPKSQHPSKKSLDHVFRESDKDNVPDKVDNVEPKELVSIPAVAVPPEQPSH 324
                 ..||.:.|..|...|.....:..:|            ||.:        |..:|..|
pombe   269 -----FQEPQRSASQPYESHALSPKVAPLF------------DNSQ--------ATPIPKRQ--- 305

  Fly   325 KTSNILKIKNHEYTIDKKLGCGGSSSVFLARRSDSGNEFALKVVD-LQADPQVVQGYLNETKLLA 388
              .:::.:.|.::.....:|.||||.|:.....|:...:|||.|: :.||...:|||.||..||.
pombe   306 --QDVVTVANLQFIKLGVVGKGGSSMVYRIFSPDNSRLYALKEVNFINADQTTIQGYKNEIALLR 368

  Fly   389 KLQGNVCVVALYDYQLVREESKLYMVMEKGDCDL-NKILQSYTTNLPLYSLMNILYQMLQAVNYI 452
            ||.||..::.||..::.....:|.||||.|:.|| |.::::....:.|..:.....|||:||..:
pombe   369 KLSGNDRIIKLYAAEVNDTLGQLNMVMECGETDLANLLMKNMKKPINLNFIRMYWEQMLEAVQVV 433

  Fly   453 HQHGVIHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSIIKFSQAGTFNYISPEALTDTST-GN 516
            |...::||||||||||:|.|.|||||||||..|..|:|:|.:.|..||.||::||||||.:. .|
pombe   434 HDQNIVHSDLKPANFLLVEGNLKLIDFGIAKAIGNDTTNIHRDSHIGTINYMAPEALTDMNAHTN 498

  Fly   517 SPMRRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHIRNVYAKMSAITTPGTSIEYP--AIP 578
            |.::     .:|:...|||||||||||.::|.:.||.|::.:.| ::||......|.:|  |:|
pombe   499 SGVK-----LVKLGRPSDVWSLGCILYQMVYGRAPFAHLKMIQA-IAAIPNEQYHIHFPEVALP 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	103/249 (41%)
mph1	NP_595150.2	PKc_Mps1	315..603	CDD:271033	103/248 (42%)