Protein Alignment Mps1 and Ttk

DIOPT Version :9

• Sequence 1: NP_001262677.1
• Gene: Mps1 / 42126
• FlyBaseID: FBgn0000063
• Length: 672
• Species: Drosophila melanogaster
• Sequence 2: XP_006511121.1
• Gene: Ttk / 22137
• MGIID: 1194921
• Length: 869
• Species: Mus musculus
• Alignment Length: 672
• Identity: 192/672 - (28%)
• Similarity: 290/672 - (43%)
• Gaps: 151/672 - (22%)

  Fly     8 RTKDMMALGLDSDSEDDF-------------NTPYRPRQAAAGERKQQPVASFQVQTRGKENEPH 59
            |..::.|:....|:.|.|             :..:...:.:.|..|:..      |...|..|..
Mouse   149 RLAELKAIQEPDDARDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSE------QLLHKAVETG 207

  Fly    60 PLPINMLPRRVSELTMMDSD-SDEEDIKSNHNLNCAILNDSFVLSPSQELTNSNSNITTRRTPSA 123
            .:|:.||...:..|.:.... ..|||.||        ::.|.|||..:..::|..|:..|
Mouse   208 AVPLQMLETAMRNLHLQKKQLLPEEDKKS--------VSASTVLSAQEPFSSSLGNVQNR----- 259

  Fly   124 APLKQSDSNLSFLGRFNDMGINCSSQGSPVA-------------------NSEKQ--VAKKTAPT 167
                               .|:|.|:|...|                   |..||  .||::.|
Mouse   260 -------------------SISCESRGQAGAARVLYGENLPPQDAEVRHQNPFKQTHAAKRSCP- 304

  Fly   168 LQAAPSATERRP--LQETETPLRNELPSTSKTKPDADFITPQVRTIG------------------ 212
            ....|......|  ..:|::....:|.:...:.||.|.|.|..|..|
Mouse   305 FGRVPVNLLNSPDFYVKTDSSAVTQLTTRKGSGPDRDAILPGSRPRGSDSYELRGLKPIQTIYLK 369

  Fly   213 -STLAGKSRSAVSNDFRAQK--------VLFQTPMTVSRAAPVASDSISFSLC--------DTIT 260
             |.::.:..|.:.:|..|.|        .|.:|...::...|:...|.....|        ..:.
Mouse   370 DSLVSNEKSSELMSDLIALKSKTDSSLTKLEETKPEIAERRPMQWQSTRKPECVFQNPAAFAPLR 434

  Fly   261 ESPDI-PEPPKKAEPPKS-----------QHPSKKSLDHVFR----ESDKDNVPDKVDNVEP-KE 308
            ..||: |:..|:..||.|           :.||..|||...:    ...|::.|....:..| .:
Mouse   435 HVPDVTPKADKEQSPPISVPKWLDPKSACETPSSSSLDDYMKCFKTPVVKNDFPPACPSSTPYSQ 499

  Fly   309 LVSI-----PAVAVPPE----QPSHKTSNILKIKNHEYTIDKKLGCGGSSSVFLARRSDSGNEFA 364
            |..:     ..::.|.:    ..|...:..:.:....|:|.|::|.||||.||.. .::.....|
Mouse   500 LARLQQQQQQGLSTPLQSLQISGSSSINECISVNGRIYSILKQIGSGGSSKVFQV-LNEKKQINA 563

  Fly   365 LKVVDLQ-ADPQVVQGYLNETKLLAKLQGNV-CVVALYDYQLVREESKLYMVMEKGDCDLNKILQ 427
            :|.|:|: ||.|.::.|.||...|.|||.:. .::.||||::.  |..:|||||.|:.|||..|:
Mouse   564 IKYVNLEDADSQTIESYRNEIAFLNKLQQHSDKIIRLYDYEIT--EQYIYMVMECGNIDLNSWLK 626

  Fly   428 SYTTNLPLYSLMNILYQMLQAVNYIHQHGVIHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSI 492
            ...:..| :...:....||:||:.|||||::|||||||||::|.|.|||||||||:.:..|:|||
Mouse   627 KKKSINP-WERKSYWKNMLEAVHIIHQHGIVHSDLKPANFVIVDGMLKLIDFGIANQMQPDTTSI 690

  Fly   493 IKFSQAGTFNYISPEALTDTSTG--NSPMRRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHI 555
            :|.||.||.||::|||:.|.|:.  ||.:|      .|:|.:|||||||||||.:.|.:|||.||
Mouse   691 VKDSQVGTVNYMAPEAIRDMSSSRENSKIR------TKVSPRSDVWSLGCILYYMTYGRTPFQHI 749

  Fly   556 RNVYAKMSAITTPGTSIEYPAI 577
            .|..:|:.||..|...||:|.|
Mouse   750 INQVSKLHAIINPAHEIEFPEI 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	116/247 (47%)
		S_TKc	337..575	CDD:214567	114/241 (47%)
Ttk	XP_006511121.1	TPR repeat	143..172	CDD:276809	5/22 (23%)
		TPR repeat	177..205	CDD:276809	4/33 (12%)
		PKc_Mps1	535..803	CDD:271033	116/247 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850669
Domainoid	1	1.000	186	1.000	Domainoid score	I3353
eggNOG	1	0.900	-	-		E1_KOG0596
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3763
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005632
OrthoInspector	1	1.000	-	-		oto94534
orthoMCL	1	0.900	-	-		OOG6_103440
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R740
SonicParanoid	1	1.000	-	-		X4035
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.680