Protein Alignment CG14325 and NOD2

DIOPT Version :10

• Sequence 1: NP_650641.2
• Gene: CG14325 / 42123
• FlyBaseID: FBgn0038531
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_071445.1
• Gene: NOD2 / 64127
• HGNCID: 5331
• Length: 1040
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 77/307 - (25%)
• Similarity: 117/307 - (38%)
• Gaps: 75/307 - (24%)

  Fly   169 INQLEISFLQPAPPTTDANDHIPLDYLLSNLPDLRQLRLSY-STKTVGCNYQMGC---------- 222
            :..|:::|....|....|     |.::|.:|.....|:|.| |...:|....:.|
Human   764 VGHLKLTFCSVGPTECAA-----LAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLR 823

  Fly   223 -NQLTVRDILHLTKGLSQCHELRTFCLHNTKLMPYQLRFLAHSLDKGCHHLTEMSLLHCA----- 281
             |.::.|.|..|.:....|.:|:...|.|.|            |..||.| :...||.|.
Human   824 DNNISDRGICKLIECALHCEQLQKLALFNNK------------LTDGCAH-SMAKLLACRQNFLA 875

  Fly   282 -------VGDAGIRCFLETCGKESFGTLTVLDLTNNKITEEGAYILSRTL-RHVPLEKLVLRLNP 338
                   :..||.:...|  |.....:|..|....|::.:|||..|:..| .|..|..|.|..|.
Human   876 LRLGNNYITAAGAQVLAE--GLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNN 938

  Fly   339 IQSDGAAAIFNTL--QVMPIKEL--------DLGTCGITETITKLFMMLICQHTSLLEIDLSNNS 393
            |.|.||.|:...|  .|| ::||        |.|.|.:.|.:.|        ::||..:.||||.
Human   939 IGSVGAQALALMLAKNVM-LEELCLEENHLQDEGVCSLAEGLKK--------NSSLKILKLSNNC 994

  Fly   394 LGEDFGKHLMKIISCNKLLERLDLRNTGLSLDMRRKFQEFLLKNVDR 440
            :         ..:....||:.|:..:|.|.:.:|.  ..|.|:.||:
Human   995 I---------TYLGAEALLQALERNDTILEVWLRG--NTFSLEEVDK 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14325	NP_650641.2	RNA1	<185..434	CDD:444072	70/283 (25%)
		leucine-rich repeat	202..239	CDD:275380	10/48 (21%)
		leucine-rich repeat	240..271	CDD:275380	8/30 (27%)
		leucine-rich repeat	272..301	CDD:275380	7/40 (18%)
		leucine-rich repeat	302..326	CDD:275380	8/24 (33%)
		leucine-rich repeat	329..353	CDD:275380	10/25 (40%)
		leucine-rich repeat	356..383	CDD:275380	7/34 (21%)
		leucine-rich repeat	384..407	CDD:275380	5/22 (23%)
NOD2	NP_071445.1	DD	34..119	CDD:472698
		ATG16L1-binding motif. /evidence=ECO:0000269|PubMed:23376921	63..77
		NACHT	123..>631	CDD:444362
		CARD_NOD2_2_CARD15	134..214	CDD:260056
		Required for CARD9 binding. /evidence=ECO:0000269|PubMed:24960071	241..274
		NACHT	293..463	CDD:428606
		NLRC4_HD2	603..757	CDD:465499
		RNA1	<757..1031	CDD:444072	77/307 (25%)
		leucine-rich repeat	764..791	CDD:275381	7/31 (23%)
		LRR 1	791..812		5/20 (25%)
		leucine-rich repeat	795..816	CDD:275380	6/20 (30%)
		LRR 2	816..839		4/22 (18%)
		leucine-rich repeat	820..844	CDD:275380	5/23 (22%)
		LRR 3	844..865		8/33 (24%)
		leucine-rich repeat	845..868	CDD:275380	9/35 (26%)
		leucine-rich repeat	869..900	CDD:275380	5/32 (16%)
		LRR 4	872..884		0/11 (0%)
		LRR 5	900..920		6/19 (32%)
		leucine-rich repeat	901..928	CDD:275380	9/26 (35%)
		LRR 6	928..949		9/20 (45%)
		leucine-rich repeat	929..952	CDD:275380	9/22 (41%)
		LRR 7	956..976		6/20 (30%)
		leucine-rich repeat	957..984	CDD:275380	7/34 (21%)
		LRR 8	984..1005		7/29 (24%)
		leucine-rich repeat	985..1006	CDD:275380	7/29 (24%)
		LRR 9	1012..1032		7/21 (33%)