DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14325 and CG8197

DIOPT Version :9

Sequence 1:	NP_650641.2	Gene:	CG14325 / 42123	FlyBaseID:	FBgn0038531	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001286225.1	Gene:	CG8197 / 35912	FlyBaseID:	FBgn0033369	Length:	387	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	89/404 - (22%)
Similarity:	142/404 - (35%)	Gaps:	129/404 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PSEDQEDQTNQAKSLRHLVLDSIVENWSELPLYRQ-----------LGRR----EDR----NYLL 87
            |.|.......:::....|:|......:.:.| |||           :|||    .|.    ||||
  Fly    12 PKECPSPAAEKSRLFTILLLYCWQREYDKRP-YRQFQFKRLTFEERIGRRYHCIRDLRIIVNYLL 75

  Fly    88 SHLDTQLPLQLLS-------AHIREDFFWQRCYGHRWRSAPLQARGRERPWINIYMERHVQEFIE 145
            ..  .||.:|:.|       |.:.:||.  |.....|             :|.:.:.|..:||.
  Fly    76 RR--PQLSVQISSLVVSNWDAGLLKDFV--RSLLPVW-------------YIELRLMRFPREFF- 122

  Fly   146 NMPTGDYEQDGNVQVVLDICAAYINQLEISFLQPAPPTTDANDHIPLDYLLSNLPDLRQLRLSYS 210
                          |:|.:.||.:|..::|.  ...|.||.:..|..::||.: ..||:|.:|..
  Fly   123 --------------VMLRLNAAKMNVSQLSL--EGTPLTDEDVRILREFLLVS-KTLRRLNVSSC 170

  Fly   211 TKT-------------------VGCNYQMGCN-----------------------------QLTV 227
            :.|                   :..|..:|.:                             :||.
  Fly   171 SLTQFNFALIADGVYKSPGVRRLSANRLLGMSLSLDTEKISSVLSSLLMQNTLWALSLEHCELTA 235

  Fly   228 RDIL----HLTKGLSQCHELRTFCLHNTKLMPYQLRFLAHSLDKGCHHLTEMSLLHCAVGDAG-- 286
            :|::    ||.:..|:...||..|   .|:.|....||...:..| .:|..:.|.:|::|..|
  Fly   236 QDMIPIAEHLARTNSKFRRLRIAC---NKIGPDGAFFLLRGMSMG-GNLELLDLSYCSIGTHGGE 296

  Fly   287 -IRCFLETCGKESFGTLTVLDLTNNKITEEGA-YILSRTLRHVPLEKLVLRLNPIQSDGAAAIFN 349
             :..:|.:|.:     |.||.|..|.:..... .||....:...||||.|..|...|..|..:..
  Fly   297 WVAKYLASCRR-----LQVLHLNYNDMGPTAVNLILLAMKKQCKLEKLTLYGNHFDSRTAMIVRR 356

  Fly   350 TL--QVMPIKELDL 361
            .|  :|:...|||:
  Fly   357 LLDAEVVLHSELDI 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14325	NP_650641.2	leucine-rich repeat	202..239	CDD:275380	12/88 (14%)
		LRR_RI	<206..440	CDD:238064	45/214 (21%)
		leucine-rich repeat	240..271	CDD:275380	8/30 (27%)
		leucine-rich repeat	272..301	CDD:275380	7/31 (23%)
		leucine-rich repeat	302..326	CDD:275380	7/24 (29%)
		leucine-rich repeat	329..353	CDD:275380	9/25 (36%)
		leucine-rich repeat	356..383	CDD:275380	3/6 (50%)
		leucine-rich repeat	384..407	CDD:275380
CG8197	NP_001286225.1	leucine-rich repeat	134..161	CDD:275381	7/29 (24%)
		LRR_RI	137..374	CDD:238064	55/246 (22%)
		leucine-rich repeat	162..189	CDD:275381	5/26 (19%)
		leucine-rich repeat	202..220	CDD:275380	0/17 (0%)
		leucine-rich repeat	223..251	CDD:275380	5/27 (19%)
		leucine-rich repeat	252..279	CDD:275380	8/30 (27%)
		leucine-rich repeat	280..307	CDD:275380	7/26 (27%)
		leucine-rich repeat	308..335	CDD:275380	7/26 (27%)
		leucine-rich repeat	336..357	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24107
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100