Protein Alignment MEIS2 and caup

DIOPT Version :10

• Sequence 1: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 104/483 - (21%)
• Similarity: 157/483 - (32%)
• Gaps: 144/483 - (29%)

Human    12 GGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV----MPASMGSAVNDA 72
            ||....|:.|.    |.:|..:....|       ||.....:.:|..:|    :|..:.||..|.
  Fly    47 GGSTATGLTAG----PLSPGAVSQSSH-------HAGHKGLSTSPAEDVVGGDVPVGLSSAAQDL 100

Human    73 LKRDKDAIYGHPLF--PLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKP 135
            ..|......|.|:.  |:.......|:.   .|....:.|....:..|....:.|:.    ...|
  Fly   101 PSRGSCCENGRPIITDPVSGQTVCSCQY---DPARLAIGGYSRMALPSGGVGVGVYG----GPYP 158

Human   136 LFSSNP----ELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSS 196
            ....||    .:||....|                                 |:......:|.|
  Fly   159 SNEQNPYPSIGVDNSAFYA---------------------------------PLSNPYGIKDTS- 189

Human   197 KSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVAS 261
                     .||.:     |:|      ||.....|.|..|                 .|.::|:
  Fly   190 ---------PSTEM-----SAW------TSASLQSTTGYYS-----------------YDPTLAA 217

Human   262 PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNW 326
            .|.|    |:.|...::|.......||  ::|||.:|..:|||::.:|..||..|.:|:.||:.|
  Fly   218 YGYG----PNYDLAARRKNATRESTAT--LKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTW 276

Human   327 FINARRRIVQP---MIDQSNRA-----GFLLDPSVSQGA---------AYSPEGQPMGSFV---- 370
            |.|||||:.:.   ..:..|:.     |.:.|....:.|         |:.|..|.:.|.:
  Fly   277 FANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAE 341

Human   371 ----LDGQQHMGI--RPAGLQSMPG--DYVSQGGPMGMSMAQPSYTPPQMT---PHPTQLRHGPP 424
                ..|.|.:.:  .|..|.:|.|  .|.:..|...|..|..||.....|   |||.|::|
  Fly   342 KEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQH--- 403

Human   425 MHSYLPSHPHHPAMMMH---GGPPTHPG 449
             |........:...:.|   ..|..|||
  Fly   404 -HQQQQQQQQNQQQLQHHQMDQPYYHPG 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		17/125 (14%)
		Meis_PKNOX_N	110..194	CDD:465140	10/87 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		18/89 (20%)
		Homeobox_KN	295..333	CDD:428673	17/37 (46%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		15/33 (45%)
		Transcriptional activation domain	340..477		32/142 (23%)
caup	NP_524046.2	Homeobox_KN	245..283	CDD:428673	17/37 (46%)
		IRO	455..472	CDD:214716