Protein Alignment MEIS2 and ara

DIOPT Version :10

• Sequence 1: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 91/383 - (23%)
• Similarity: 135/383 - (35%)
• Gaps: 101/383 - (26%)

Human   177 SCLKGKMPI--DLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGG 239
            ||.:...||  |.|..:...|.:.|...|:.||.:..           .|.|....|||.||:..
  Fly   131 SCCENGRPIMTDPVSGQTVCSCQYDSARLALSSYSRL-----------PAASVGVYGTPYPSTDQ 184

Human   240 HASQS-GDNSS------EQGDGLDNSVASPGTGD-------------DDDP-------------- 270
            :..|| |.:||      ....||.::.|.|..|.             ..||
  Fly   185 NPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGGLLVSNSSY 249

Human   271 --DKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
              ..|...::|.......||  ::|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||
  Fly   250 GASYDLAARRKNATRESTAT--LKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 312

Human   334 IVQ-----------------PMIDQSNRAGFLLDPSV-SQGAA--YSPEGQPMGSFVLDGQQHMG 378
            :.:                 .::....:....|:||. |||:.  ...|.:.....:.:.|:.:|
  Fly   313 LKKENKMTWEPKNRTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKDETKEEEDAIDEDQKCLG 377

Human   379 ---IRPAGLQSMPGDYVSQG-------GPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHP 433
               |..||.     .|.|.|       |..|.|...|....|....||...:.| .....||.|.
  Fly   378 QANILRAGF-----GYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAG-QQGGMLPFHG 436

Human   434 HHPAMMMHGGPPTHP-----GMTMSAQSPTMLNSVD---------PNVGGQVMDIHAQ 477
            .:..:....|.|.:.     |:.:.|..|.:.:..|         ..:|.|.|.:..|
  Fly   437 ENSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLADTVGCKTPPPAYMGHQSMPLQQQ 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		6/15 (40%)
		Meis_PKNOX_N	110..194	CDD:465140	6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		26/125 (21%)
		Homeobox_KN	295..333	CDD:428673	17/37 (46%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		15/33 (45%)
		Transcriptional activation domain	340..477		35/163 (21%)
ara	NP_524045.2	COG5576	<237..>318	CDD:227863	25/82 (30%)
		Homeobox_KN	274..312	CDD:428673	17/37 (46%)