Protein Alignment MEIS2 and vis

DIOPT Version :10

• Sequence 1: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_788337.1
• Gene: vis / 36372
• FlyBaseID: FBgn0033748
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 74/262 - (28%)
• Similarity: 114/262 - (43%)
• Gaps: 46/262 - (17%)

Human   185 IDLVIDERDGSSKSD--HE-ELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGD 246
            :::|:|.....:..|  || .:..|..|    |....|.|.|::....:        .||....|
  Fly     9 VNMVLDRHVRQNIKDLMHEAHVHASLLN----NEGRDRFHSDSSLDQDS--------LHAVVGND 61

Human   247 NSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQ 311
            .|:|||.....:........:...|.:...:|:||..||.:..|::.||::|..:.|||:.:|..
  Fly    62 LSTEQGANQVQNYHDMMVDSEHHVDINGSLRKRRGNLPKSSVKILKRWLYEHRYNAYPSDAEKFT 126

Human   312 LAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDP---SVSQ------GAAYSPEGQPMG 367
            |:|:..||:|||.||||||||||:..||.:...     ||   ::|:      ||....:|.
  Fly   127 LSQEANLTVLQVCNWFINARRRILPEMIRREGN-----DPLHFTISRRGKKVVGATEEVDGA--- 183

Human   368 SFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMG-MSMAQPSYTPPQMTPHPTQLRHGP----PMHS 427
                 |:.|.||  |.:.:....||.  ||.| |...:|.|....:......:.:.|    .:||
  Fly   184 -----GEIHEGI--ANVLTNFEQYVQ--GPNGQMVKMEPEYEDSVIYSWQQAIANNPMGFQSLHS 239

Human   428 YL 429
            .|
  Fly   240 SL 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		1/5 (20%)
		Meis_PKNOX_N	110..194	CDD:465140	2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		20/92 (22%)
		Homeobox_KN	295..333	CDD:428673	20/37 (54%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		18/33 (55%)
		Transcriptional activation domain	340..477		23/104 (22%)
vis	NP_788337.1	Homeobox_KN	110..148	CDD:428673	20/37 (54%)