DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sll and slc35b2

DIOPT Version :9

Sequence 1:	NP_001247153.1	Gene:	sll / 42115	FlyBaseID:	FBgn0038524	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_991198.1	Gene:	slc35b2 / 402931	ZFINID:	ZDB-GENE-050213-1	Length:	435	Species:	Danio rerio

Alignment Length:	432	Identity:	218/432 - (50%)
Similarity:	288/432 - (66%)	Gaps:	33/432 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SDLLRAS-LGGYYNQDVTLSQLVESQNSDYAWFLKLLVNCFGYSCVFVPGFLIYKYVGRINYLER 93
            :|.:.|| |||:  |||              |..:|.:|..||:.:.:||:.:..|..|:||||.
Zfish    22 ADAVDASLLGGW--QDV--------------WLFRLFLNVLGYATIIIPGYFLISYFKRVNYLET 70

  Fly    94 GNKTFLHKAINMCITGNSGYDQLDAGTSTADKDRPAASTAPKRTSS-QEAVQLLWCFGGLMISYL 157
            | :......|..|:.||      ::.|...|...||.....:.:|| ::|.:|::|..||.:|||
Zfish    71 G-RGLCFPLIKTCVFGN------ESKTGLLDDASPAGRNESESSSSARQAFKLIFCAAGLQVSYL 128

  Fly   158 TWGVLQEKIMTQNY--LNFTGESAKFKDSQFLVFSNRLLAFLVA--LAYLQWQPSPVRHRAPLYK 218
            |||||||::||::|  ....|...:|:|||||||.||:||..|:  ...|..||   ||.||:||
Zfish   129 TWGVLQERVMTRSYGSSEAEGSGERFRDSQFLVFMNRILALTVSGLWCVLFKQP---RHGAPMYK 190

  Fly   219 YSYASFSNIMSAWFQYEALKFVNFPTQVLAKSCKIIPVMLMGKIMSKAKYESYEYVTALLISLGM 283
            ||:||.|||:|:|.|||||||::||||||||:.|:|||||||||:|:..||.:||:||:|||||:
Zfish   191 YSFASLSNILSSWCQYEALKFISFPTQVLAKASKVIPVMLMGKIVSRKSYEYWEYLTAVLISLGV 255

  Fly   284 IFFMSGSSDSSKASGVTTLTGIFLLSMYMVFDSFTANWQGSLFKSYGMTPLQMMCGVNLFSSIFT 348
            ..|:..||.....|.|||.:|:.:|:.|:||||||:|||.:||| |.|:.:|||.||||||.:||
Zfish   256 SMFLLSSSTDKHPSTVTTFSGVLILAGYIVFDSFTSNWQDNLFK-YKMSSVQMMFGVNLFSCLFT 319

  Fly   349 GASLSMQGGFMDSLAFATEHPKFVFDMVVLSVCSAVGQLFIYHTIDVFGPVVFTIIMTLRQAVAI 413
            ..||..||.|.:||||.|.|.:|.|..|:||||||.|||||:.||..||..|||||||||||:||
Zfish   320 VGSLLEQGAFFNSLAFMTRHSEFAFHAVLLSVCSAFGQLFIFFTIAQFGAAVFTIIMTLRQALAI 384

  Fly   414 MLSCFIYQHSISLLGIFGVLIVFVAIFLRVYCTQRLRAIRKR 455
            :||||:|.|.:||.|..||.:||:|:|||:|...|::...||
Zfish   385 LLSCFLYGHPVSLTGGLGVGVVFLALFLRIYARSRVKKSTKR 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sll	NP_001247153.1	UAA	144..444	CDD:285625	180/303 (59%)
slc35b2	NP_991198.1	UAA	115..417	CDD:285625	181/305 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573548
Domainoid	1	1.000	350	1.000	Domainoid score	I983
eggNOG	1	0.900	-	-		E1_COG0697
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24504
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1916
OMA	1	1.010	-	-		QHG54403
OrthoDB	1	1.010	-	-		D334764at33208
OrthoFinder	1	1.000	-	-		FOG0005467
OrthoInspector	1	1.000	-	-		oto40470
orthoMCL	1	0.900	-	-		OOG6_105624
Panther	1	1.100	-	-	LDO	PTHR10778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R581
SonicParanoid	1	1.000	-	-		X3887
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800