DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sll and pst-1

DIOPT Version :9

Sequence 1:	NP_001247153.1	Gene:	sll / 42115	FlyBaseID:	FBgn0038524	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_741546.3	Gene:	pst-1 / 178980	WormBaseID:	WBGene00004206	Length:	440	Species:	Caenorhabditis elegans

Alignment Length:	430	Identity:	154/430 - (35%)
Similarity:	240/430 - (55%)	Gaps:	21/430 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DLLRASLGGYYNQDVT---LSQLVESQN---SDYAWFLKLLVNCFGYSCVFVPGFLIYKYVGRIN 89
            |.|....|.|..|.::   :..|.|:::   .:..|.|:|.:...|||.|..|..::..||.|..
Worm     2 DPLSWGRGWYAIQTISGSVIQYLKEARDKPPDELVWPLRLFLILLGYSTVATPAAILIYYVRRNR 66

  Fly    90 YLERGNKTFLHKAINMCITGNSGYDQLDAGTSTADKDRPAASTAPKRTSSQ---EAVQLLWCFGG 151
            :........:...:.....||..|..:..|...|.|:..:.    .:|.:|   ..:.||:.|.|
Worm    67 HAFETPYLSIRLLLRSFAVGNPEYQLIPTGEKQARKENDSI----PQTRAQCINVIILLLFFFSG 127

  Fly   152 LMISYLTWGVLQEKIMTQNYLNFTGESA--KFKDSQFLVFSNRLLAFLVALAYL--QWQPSPVRH 212
            :.::.:..|||||:|:|:.|........  ||.::|||:|.||::|.:::|..|  .|...| .|
Worm   128 IQVTLVAMGVLQERIITRGYRRSDQLEVEDKFGETQFLIFCNRIVALVLSLMILAKDWTKQP-PH 191

  Fly   213 RAPLYKYSYASFSNIMSAWFQYEALKFVNFPTQVLAKSCKIIPVMLMGKIMSKAKYESYEYVTAL 277
            ..|||.:||.||||.:|:|.||||||:|:||||.:.|:.|::..||||:::...:|..:||....
Worm   192 VPPLYVHSYTSFSNTISSWCQYEALKYVSFPTQTICKASKVVVTMLMGRLVRGQRYSWFEYGCGC 256

  Fly   278 LISLGMIFFMSGSSDSSKASGV--TTLTGIFLLSMYMVFDSFTANWQGSLFKSY-GMTPLQMMCG 339
            .|:.|...|:..||.....|.:  |:.:|:.|::.|::||:||.|||.:||.:. .::..|||.|
Worm   257 TIAFGASLFLLSSSSKGAGSTITYTSFSGMILMAGYLLFDAFTLNWQKALFDTKPKVSKYQMMFG 321

  Fly   340 VNLFSSIFTGASLSMQGGFMDSLAFATEHPKFVFDMVVLSVCSAVGQLFIYHTIDVFGPVVFTII 404
            ||.||:|....||..||....|:.|..||..|..|:.:||:..|:||:|||.||:.|||:||.:|
Worm   322 VNFFSAILCAVSLIEQGTLWSSIKFGAEHVDFSRDVFLLSLSGAIGQIFIYSTIERFGPIVFAVI 386

  Fly   405 MTLRQAVAIMLSCFIYQHSISLLGIFGVLIVFVAIFLRVY 444
            ||:||.::|:||..:|.|.::.|...|.:|||.|||:.::
Worm   387 MTIRQMLSIVLSTIMYGHELTFLAAIGFMIVFAAIFVDIH 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sll	NP_001247153.1	UAA	144..444	CDD:285625	128/306 (42%)
pst-1	NP_741546.3	UAA	121..423	CDD:285625	127/302 (42%)
pst-1	NP_741546.3	EamA	312..423	CDD:304911	51/110 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156150
Domainoid	1	1.000	244	1.000	Domainoid score	I1221
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H24504
Inparanoid	1	1.050	262	1.000	Inparanoid score	I1901
Isobase	1	0.950	-	0	Normalized mean entropy	S2363
OMA	1	1.010	-	-		QHG54403
OrthoDB	1	1.010	-	-		D334764at33208
OrthoFinder	1	1.000	-	-		FOG0005467
OrthoInspector	1	1.000	-	-		oto20648
orthoMCL	1	0.900	-	-		OOG6_105624
Panther	1	1.100	-	-	LDO	PTHR10778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R581
SonicParanoid	1	1.000	-	-		X3887
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890