Protein Alignment Hmx and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 620
• Identity: 127/620 - (20%)
• Similarity: 180/620 - (29%)
• Gaps: 250/620 - (40%)

  Fly    23 AAARDSPLLARSPARSADGSSPPATPTHRSNTPNTAAGTPTTSASGGNHFHHSPSGGAVPPAVLH 87
            ||..|.|.|...|.....|.:|||......:|.:..|..|....:|            |||
Mouse     7 AAPGDVPALPPPPPGPGSGPAPPAPAATARDTMDGRAELPIFPRAG------------VPP---- 55

  Fly    88 HHLQHHLSSLGSHPVALHHALHTFGHLHPAHGATHPALLQHALTPTGQQQQQQLQVQQQHQQSHV 152
                  |::..:.|.....|           ||..||      .|........|.:...::.:..
Mouse    56 ------LAASDTVPAVPEGA-----------GAARPA------APPRPTSFSVLDILDPNKFNSR 97

  Fly   153 ER----LSPPMKSPERNGGDEVQGHSLNNNNSKALNHNNTCASAAAAAAAAAVAAANLSNNS--- 210
            .|    |.|.:.:                          |||..|.||..|..||:..|..:
Mouse    98 RRRCVLLGPVVPA--------------------------TCAPCAPAACVAVPAASGRSPRAELE 136

  Fly   211 ----NDSNGSSGGGGGKSTTGSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQLPQPGAGGPQD 271
                :.:.|.:...|.:.|:..:.:          |::.|:.||.:.           |:|
Mouse   137 RRALSAATGVAAAAGAEPTSAGDSY----------RADEAEANGYSS-----------GSG---- 176

  Fly   272 AAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNN 336
                                                 .|||.||...            :|.:.:
Mouse   177 -------------------------------------RSPTADSEDE------------APEDED 192

  Fly   337 NNSNTTASSNQASKSP-----------SHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQHPQQQQ 390
            ..........|.::.|           |..|        |:.:.:.........|    .|:...
Mouse   193 EEEAPEVQDAQGTEEPRGGSGGLGARGSGCP--------GAAEVEASPVDDTAAP----GPRGNS 245

  Fly   391 QQHPHQPTTPTSSSSSGG---GSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDG 452
            ...|..|.|.|.:.|:|.   |:::|..|....|||
Mouse   246 PGAPGPPATATGAGSAGSTPQGAAVTTKPKRKRTGS----------------------------- 281

  Fly   453 PSDSSSPHGDGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQ 517
                     |..|.:.::.||.|:..|:..||:.|...||||..||..||.||.|||||||||||
Mouse   282 ---------DSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQ 337

  Fly   518 NRRNKWKRQ-LAAELEAANMANMAHAAQRLVRVPVLYHDGTTAGFVPPPPPHHHPMQYYAAARNT 581
            |||.|||:| ..|:..|..                    |...|    |.|...|........:.
Mouse   338 NRRTKWKKQNPGADTSAPT--------------------GGGGG----PGPGAGPGAGLPGGLSP 378

  Fly   582 SPPRPPLSSLVXGVGCLATAPMSLLKPPNSMAHPP 616
            ..|.||:.           ||::|..|....||.|
Mouse   379 LSPSPPMG-----------APLALHGPAGYPAHSP 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	33/55 (60%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		25/113 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		36/269 (13%)
		Homeodomain	289..345	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		14/79 (18%)