DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hmx and Nkx6-1

DIOPT Version :10

Sequence 1:NP_001262674.1 Gene:Hmx / 42110 FlyBaseID:FBgn0264005 Length:718 Species:Drosophila melanogaster
Sequence 2:NP_113925.1 Gene:Nkx6-1 / 65193 RGDID:69318 Length:365 Species:Rattus norvegicus


Alignment Length:527 Identity:120/527 - (22%)
Similarity:162/527 - (30%) Gaps:238/527 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LGAAARDSP-----LLARSPARSADGSSPPATPTHRSNTPNTAAGTPTTSASGGNHFHHSPSGGA 80
            |...|.:.|     ||:..|..:....:...||.:.:..|....|.|::|:|..:....||..||
  Rat     2 LAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPLGA 66

  Fly    81 VPPAVLHHHLQHHLSSLGSHPVALHHALHTFGHLHPAHGATHPALLQHALTPTGQQQQQQLQVQQ 145
            ..|..|.......||||||.|                                     |||....
  Rat    67 HNPGGLKPPAAGGLSSLGSPP-------------------------------------QQLSAAT 94

  Fly   146 QHQQSHVERLSPPMKSPERNGGDEVQGHSLNNNNSKALNHNNTCASAAAAAAAAAVAAANLSNNS 210
            .|..:.:  ||.| ..|..:|..........:::|.:.:.:.|.|||||||||||.|||      
  Rat    95 PHGINDI--LSRP-SMPVASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAA------ 150

  Fly   211 NDSNGSSGGGGGKSTTGSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQL-----PQPGAG--- 267
                                           .|.|      |||:..:|:.     |.|..|   
  Rat   151 -------------------------------ASSP------AGLLAGLPRFSSLSPPPPPPGLYF 178

  Fly   268 GPQDAAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSP 332
            .|..||:           |..|||                                 |.|.:..|
  Rat   179 SPSAAAV-----------AAVGRY---------------------------------PKPLAELP 199

  Fly   333 NNNNNNSNTTASSNQASKSPSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQP 397
            ...                       |::.| |..|                             
  Rat   200 GRT-----------------------PIFWP-GVMQ----------------------------- 211

  Fly   398 TTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSSPHGD 462
                  |.....:.|...||      .|..||       |::|                      
  Rat   212 ------SPPWRDARLACTPH------QGSILL-------DKDG---------------------- 235

  Fly   463 GNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQL 527
                ::|.||..||..|:|.||.||:..:||:..|||.||.||.:||:|||:||||||.||:::.
  Rat   236 ----KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKH 296

  Fly   528 AAELEAA 534
            |||:..|
  Rat   297 AAEMATA 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmxNP_001262674.1 Homeodomain 469..525 CDD:459649 33/55 (60%)
Nkx6-1NP_113925.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..136 29/140 (21%)
Repressor domain. /evidence=ECO:0000250 102..269 68/352 (19%)
Homeodomain 236..294 CDD:459649 33/57 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 4/9 (44%)
Involved in DNA-binding. /evidence=ECO:0000250 307..365
Blue background indicates that the domain is not in the aligned region.

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