Protein Alignment Hmx and Barhl2

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_075245.1
• Gene: Barhl2 / 65050
• RGDID: 620726
• Length: 384
• Species: Rattus norvegicus
• Alignment Length: 451
• Identity: 123/451 - (27%)
• Similarity: 167/451 - (37%)
• Gaps: 130/451 - (28%)

  Fly   227 GSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRY 291
            |::| :||.|.:|||        ||             |:|.|               |.:.|.:
  Rat     6 GASG-SSFGIDTILS--------GA-------------GSGSP---------------GMMNGDF 33

  Fly   292 AALCPPG----WPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNNNNSNTTASSNQASKSP 352
            .:|   |    ..:..|..|  ||..:..:..|..:.|...::.|          ...:..:..|
  Rat    34 RSL---GEARTTDFRSQATP--SPCSEIDTVGTAPSSPISVTLEP----------PEPHLVTDGP 83

  Fly   353 SHHPLHPLYH------PLGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSS-------- 403
            .||  |.|:|      |.....|..|....||.|.|.|...||.......|.|.|||
  Rat    84 QHH--HHLHHGQQPPPPSAPPAQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSSFLIKDILG 146

  Fly   404 ---------SSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSSP 459
                     ..|...||..|.|......:|..:.......:|..:.::  .||..:|.....:..
  Rat   147 DSKPLAACAPYSTSVSSPHHTPKQECNAAHESFRPKLEQEDSKTKLDK--REDSQSDIKCHGTKE 209

  Fly   460 HGDG-----------NSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVK 513
            .||.           .:|:.:|.||.||..|:.|||.:|:.::|||..:|..|||:|.||:||||
  Rat   210 EGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVK 274

  Fly   514 IWFQNRRNKWKRQLAAELEAANMANMAHAAQRLVRVPVLYH-------DGTTAG----------F 561
            .|:||||.|||||.|..||....|....|.||:...|..||       |.|||.          :
  Rat   275 TWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAMYSSMY 339

  Fly   562 VPPPPPH---HHPMQYYAAARNTSPPRPPLSSLVXGVGCLATAPMSLLKPPNSMAHPPHPQ 619
            ..||.||   ..|:          .||..:..|..| |..|..|:|     |.:...|||:
  Rat   340 RTPPAPHPQLQRPL----------VPRVLIHGLGPG-GQPALNPLS-----NPIPGTPHPR 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	31/55 (56%)
Barhl2	NP_075245.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134		41/181 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..237		16/84 (19%)
		Homeodomain	230..286	CDD:459649	31/55 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..384		8/25 (32%)