DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmx and hmx3a

DIOPT Version :9

Sequence 1:	NP_001262674.1	Gene:	Hmx / 42110	FlyBaseID:	FBgn0264005	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_571709.2	Gene:	hmx3a / 60310	ZFINID:	ZDB-GENE-001020-1	Length:	297	Species:	Danio rerio

Alignment Length:	221	Identity:	116/221 - (52%)
Similarity:	133/221 - (60%)	Gaps:	46/221 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 QQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEE-----GEEII-EEDD 448
            |:.....|||.|...|            |.|       :|.|..:..|:|     |:||: ||.|
Zfish    98 QKARDSSPTTGTDRDS------------PEL-------VLKSDPDAKDDEDDNKSGDEIVLEESD 143

  Fly   449 GTDGPS----DSSSPHGDGNSK---RKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLR 506
            ..||..    |......||..|   |||||||||||:||||||||||:||||||||||||||||.
Zfish   144 TEDGKKEGGIDDWKKSDDGADKKPCRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLH 208

  Fly   507 LTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQRLVRVPVLYHDGT------TAGFVPPP 565
            |||||||||||||||||||||||||||||:::.  ||||:||||:|||:.:      |||.||..
Zfish   209 LTETQVKIWFQNRRNKWKRQLAAELEAANLSHA--AAQRIVRVPILYHENSASESTNTAGNVPVS 271

  Fly   566 PP---HHHPMQYYAAARNTSPP--RP 586
            .|   ..||: ||:....||.|  ||
Zfish   272 QPLLTFPHPV-YYSHPIVTSVPLLRP 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeobox	471..524	CDD:278475	49/52 (94%)
hmx3a	NP_571709.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..172		26/92 (28%)
		Homeobox	173..226	CDD:278475	49/52 (94%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6091
eggNOG	1	0.900	-	-		E1_KOG0485
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003349
OrthoInspector	1	1.000	-	-		otm25716
orthoMCL	1	0.900	-	-		OOG6_109246
Panther	1	1.100	-	-	O	PTHR46110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4603
SonicParanoid	1	1.000	-	-		X983
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.840