Protein Alignment Hmx and lab

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 663
• Identity: 154/663 - (23%)
• Similarity: 221/663 - (33%)
• Gaps: 142/663 - (21%)

  Fly    48 PTHRSNTPNTAAGTPTTSASGGNHFHHSPSGGAVPPAVLHHHLQH-HLSSLGSHPVALHHALHTF 111
            |.|.....|...|..||:||..|...:.......|...|....|| ||.....|.....:...:.
  Fly    12 PHHHHPHANAYDGYSTTTASAANASSYFAPQQHQPHLQLQQQQQHQHLQQPQQHLTYNGYESSSP 76

  Fly   112 GHLHPAHGA--THPALLQHALTPTGQQQQQQLQVQQQHQQSHVERLSPP-----MKSPERNGGDE 169
            |:.:|...|  |.|....|.:.   ||.|||.|.|||....|....||.     :.:....|...
  Fly    77 GNYYPQQQAQLTPPPTSSHQVV---QQHQQQQQAQQQQLYPHSHLFSPSAAEYGITTSTTTGNPG 138

  Fly   170 VQGHSLNNNNSKALNHNNTCASAAAAAAAAAVA---------AANLSNNSNDSNGSSGGGGGKST 225
            ...|..:::.:.:...:::..|..|.||.|.||         |||.|..||.........   ..
  Fly   139 TPLHPSSHSPADSYYESDSVHSYYATAAVATVAPPSNSSPITAANASATSNTQQQQQQAA---II 200

  Fly   226 TGSNGFTSFSISSILSRSE-PAKKNGAAGLI-----TPIPQLPQPGAGGPQDAAMLSRLGFISQW 284
            :..||....::..:...:: .|..:|.||.|     ..:.....||........|:.:......|
  Fly   201 SSENGMMYTNLDCMYPTAQAQAPVHGYAGQIEEKYAAVLHASYAPGMVLEDQDPMMQQATQSQMW 265

  Fly   285 ---GALAGRYA----------ALCPPGWPWA------------------PQRLPFHSPTHDSSST 318
               ..|||.||          |....|.|..                  .|:.|...|.|..:.:
  Fly   266 HHQQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLANNPHQQQPQVQQQQQQPHQQPQHPQNQS 330

  Fly   319 NTTENPPSPTSMSPNNNNN-------------NSNTTASSNQA------SKSPSHHPLHPLYHPL 364
            ..........|:|||...|             .|::|::||.|      ||||:|....|.|
  Fly   331 PAAHQQHHQNSVSPNGGMNRQQRGGVISPGSSTSSSTSASNGAHPASTQSKSPNHSSSIPTY--- 392

  Fly   365 GSQQQQQQQQQHQQHPQQQQHPQQQ-QQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYL 428
                :..|.:::...||..:.|... ...|.:|..........|||........|...|.:|.
  Fly   393 ----KWMQLKRNVPKPQAPKLPASGIASMHDYQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGS-- 451

  Fly   429 LPSSSNESDEEGEEIIEEDDGTDGPSDSSSPHGDG--------------NSKRKKKTRTVFSRAQ 479
             |........:...|:.......|   |:.|:|.|              :|......||.|:..|
  Fly   452 -PGIGGVLSVQNSLIMANSAAAAG---SAHPNGMGVGLGSGSGLSSCSLSSNTNNSGRTNFTNKQ 512

  Fly   480 VFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQ 544
            :.:||..|...|||:.:.|..:|.:|:|.||||||||||||.|.|:::...|..|::
  Fly   513 LTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRVKEGLIPADI-------- 569

  Fly   545 RLVRVPVLYHDGTTAGFVPPPPPHHHPMQYYAAARNTSPPRPPLSS---------LVXGVGCLAT 600
                  :..|  :|:.....||....|          .||...|.|         |. |.....|
  Fly   570 ------LTQH--STSVISEKPPQQQQP----------QPPELQLKSQGSDLGGNELATGAPSTPT 616

  Fly   601 APMSLLKPPNSMA 613
            ..|:|..|.:..:
  Fly   617 TAMTLTAPTSKQS 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	27/55 (49%)
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	27/52 (52%)