Protein Alignment Hmx and BARHL2

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_064447.1
• Gene: BARHL2 / 343472
• HGNCID: 954
• Length: 387
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 126/467 - (26%)
• Similarity: 169/467 - (36%)
• Gaps: 158/467 - (33%)

  Fly   227 GSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRY 291
            |::| :||.|.:|||    :..:|:.|::.        |...|...|..:
Human     5 GASG-SSFGIDTILS----SASSGSPGMMN--------GDFRPLGEARTA--------------- 41

  Fly   292 AALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNNNNSNTTASSNQASKSPSHHP 356
                    .:..|..|  ||..:..:..|..:.|...:|.|...:..::.|          .||
Human    42 --------DFRSQATP--SPCSEIDTVGTAPSSPISVTMEPPEPHLVADAT----------QHH- 85

  Fly   357 LHPLYHPLGSQQQQQQQQQHQQHPQQ--QQHPQQQQQQHPHQPTTP-------------TSSSS- 405
             |.|:|       .||.......|.|  |..|||||...|.||..|             ||:||
Human    86 -HHLHH-------SQQPPPPAAAPTQSLQPLPQQQQPLPPQQPPPPPPQQLGSAASAPRTSTSSF 142

  Fly   406 -----SGGGSSL-------THHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDG---TDGPSD 455
                 .|....|       |....||.|..       ..||...|.....:|::|.   .|...|
Human   143 LIKDILGDSKPLAACAPYSTSVSSPHHTPK-------QESNAVHESFRPKLEQEDSKTKLDKRED 200

  Fly   456 SSSP---HG---DGN-------------SKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGL 501
            |.|.   ||   :|:             :|:.:|.||.||..|:.|||.:|:.::|||..:|..|
Human   201 SQSDIKCHGTKEEGDREITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDL 265

  Fly   502 AASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQRLVRVPVLYH-------DGTTA 559
            ||:|.||:||||.|:||||.|||||.|..||....|....|.||:...|..||       |.|||
Human   266 AAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTA 330

  Fly   560 G----------FVPPPPPH---HHPM----QYYAAARNTSPPRPPLSSLVXGVGCLATAPMSLLK 607
            .          :..||.||   ..|:    ..:.......|...||||.:.|.
Human   331 AAAAAAMYSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSSPIPGT------------ 383

  Fly   608 PPNSMAHPPHPQ 619
                    |||:
Human   384 --------PHPR 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	31/55 (56%)
BARHL2	NP_064447.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..145		45/196 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..240		20/89 (22%)
		Homeodomain	233..289	CDD:459649	31/55 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..387		8/39 (21%)