DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmx and HMX3

DIOPT Version :9

Sequence 1:	NP_001262674.1	Gene:	Hmx / 42110	FlyBaseID:	FBgn0264005	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001099044.1	Gene:	HMX3 / 340784	HGNCID:	5019	Length:	357	Species:	Homo sapiens

Alignment Length:	426	Identity:	144/426 - (33%)
Similarity:	182/426 - (42%)	Gaps:	157/426 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 ASAAAAAAAAAVAAANLSNNSNDSNGSSGGGGG--KSTTGSNGFTSFSISSILSRSEPAKKNGAA 252
            |||||||||||.|||         .|:..|..|  .|..|...|..|.|        ||::..
Human    59 ASAAAAAAAAAAAAA---------KGALEGAAGFALSQVGDLAFPRFEI--------PAQRFA-- 104

  Fly   253 GLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLP---FHSPTHD 314
                    ||         |..|.|                  .|.| |.|..|.   .|.|..:
Human   105 --------LP---------AHYLER------------------SPAW-WYPYTLTPAGGHLPRPE 133

  Fly   315 SS----------STNTTENPPSP-TSMSPNNNNNNSNTTASSNQASKSPSHHPLHPLYHPLGSQQ 368
            :|          ::.|..:.|.| ....|::...:          ||||....|
Human   134 ASEKALLRDSSPASGTDRDSPEPLLKADPDHKELD----------SKSPDEIIL----------- 177

  Fly   369 QQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSS 433
            ::...::.::..:                ..|.::.:|.|.::.|                |.:
Human   178 EESDSEESKKEGE----------------AAPGAAGASVGAAAAT----------------PGA- 209

  Fly   434 NESDEEGEEIIEEDDGTDGPSDSSSPHGDGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSER 498
             |..::|.|           |....|     :.|||||||||||:||||||||||:|||||||||
Human   210 -EDWKKGAE-----------SPEKKP-----ACRKKKTRTVFSRSQVFQLESTFDMKRYLSSSER 257

  Fly   499 AGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQRLVRVPVLYH-----DGTT 558
            |||||||.|||||||||||||||||||||||||||||:::.  ||||:||||:|||     :|..
Human   258 AGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHA--AAQRIVRVPILYHENSAAEGAA 320

  Fly   559 AGFVPPPPPHHHPM------QYYAAARNTSPP--RP 586
            |.....|.|...|:      .||:....:|.|  ||
Human   321 AAAAGAPVPVSQPLLTFPHPVYYSHPVVSSVPLLRP 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeobox	471..524	CDD:278475	49/52 (94%)
HMX3	NP_001099044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..229		23/170 (14%)
		Homeobox	230..283	CDD:278475	49/52 (94%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6248
eggNOG	1	0.900	-	-		E1_KOG0485
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003349
OrthoInspector	1	1.000	-	-		otm40284
orthoMCL	1	0.900	-	-		OOG6_109246
Panther	1	1.100	-	-	O	PTHR46110
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4603
SonicParanoid	1	1.000	-	-		X983
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.930