Protein Alignment Hmx and HOXB5

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 72/304 - (23%)
• Similarity: 116/304 - (38%)
• Gaps: 88/304 - (28%)

  Fly   286 ALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNNNNSN-TTASSNQAS 349
            :.:|||    |.|        |.:...:..|.::.:.:...|.:|...:...|.| ...|.|::|
Human     8 SFSGRY----PNG--------PDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSS 60

  Fly   350 KSPSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSGGGSSLTH 414
            .|.||      :..:|        :..:..|...|.|:.:|.......::|.|...:.|
Human    61 ASSSH------FGAVG--------ESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNG------ 105

  Fly   415 HPHPHLTGSHGGYLLPSSSNESDEEGEEI-------IEEDDGTDGPSDSSS-------------- 458
                   .|||.  .||:|:.||:.....       |:|...:..|.:::|
Human   106 -------DSHGA--KPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEP 161

  Fly   459 -------PHG----------------DGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAG 500
                   |.|                |......|:.||.::|.|..:||..|...|||:...|..
Human   162 MATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIE 226

  Fly   501 LAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQ 544
            :|.:|.|:|.|:||||||||.|||:.  .:|::.::|....|.|
Human   227 IAHALCLSERQIKIWFQNRRMKWKKD--NKLKSMSLATAGSAFQ 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	27/55 (49%)
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	21/126 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		21/110 (19%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	195..251	CDD:459649	27/55 (49%)