Protein Alignment Hmx and HOXB3

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_016880049.1
• Gene: HOXB3 / 3213
• HGNCID: 5114
• Length: 578
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 128/557 - (22%)
• Similarity: 172/557 - (30%)
• Gaps: 194/557 - (34%)

  Fly   211 NDSNGSSGGGGGKSTTGSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQLPQPGA--GGPQDAA 273
            |.:.|..|||.|.|.:|                             |:|||   |.  ||.....
Human    76 NKAGGGGGGGVGASASG-----------------------------PLPQL---GGTLGGCWGLL 108

  Fly   274 MLSRL--GFISQWGALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENP-----PSPTSMS 331
            .:.||  |::.:.....||.:.    .|..||.|               |:.|     |.| |..
Human   109 RVERLGCGWLRRRSPSLGRGSG----AWQSAPAR---------------TQRPAARRCPRP-SGR 153

  Fly   332 PNNNNNNSNTTASS-------------NQASKSPSHHPLHPLY-------HPLGSQQQQQQQQQH 376
            |:...:.|....|.             :..:|:.:|  |...|       ..||:.....:.::.
Human   154 PHRRGDLSPAARSGARCEYILCLPVLPSSVAKAATH--LEGDYQRSACSLQSLGNAAPHAKSKEL 216

  Fly   377 Q---QHPQQQQHPQQQQQQHP---HQPTTPTSSSSSGGG--------------SSLTHHPHPHLT 421
            .   ..|.....|.......|   ..||:.||:||:|||              |:||....|.:.
Human   217 NGSCMRPGLAPEPLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPGTNSTLTKQIFPWMK 281

  Fly   422 GSHGGYLLPSSSNESDE----------EGEEIIEEDDGTDGPSDSSSPHGDGNSKRKKKTRTVFS 476
            .|.....|.::|..:.|          .|........|..|.....||.|...|||   .||.::
Human   282 ESRQTSKLKNNSPGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKR---ARTAYT 343

  Fly   477 RAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAE----------- 530
            .||:.:||..|...|||....|..:|..|.|:|.|:||||||||.|:|:...|:
Human   344 SAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSP 408

  Fly   531 --------LEAANMANMAH----------------AAQRLVRVPVLYHD-----GTTAGFVPPPP 566
                    ...|...|..|                |.|....:|..|..     |....:.|.|.
Human   409 AGSPPQPMQSTAGFMNALHSMTPSYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPA 473

  Fly   567 PHHHP--------------MQ----YYAAARNTSPPRPPLSSLVXGVGCLATAPMSLL----KPP 609
            |.:.|              ||    |........|..||....:.|:..|:..|...|    .||
Human   474 PEYEPHVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGAPP 538

  Fly   610 NSMAHPPHPQPPPPAPLHMQQRSFLGCEQLTETDMDS 646
              ||...|..|..|.|              |.||:.|
Human   539 --MAPSQHHGPCEPHP--------------TYTDLSS 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	25/55 (45%)
HOXB3	XP_016880049.1	Homeodomain	336..392	CDD:459649	27/58 (47%)
		DUF4074	513..576	CDD:463833	16/63 (25%)