Protein Alignment Hmx and HMX2

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_005510.1
• Gene: HMX2 / 3167
• HGNCID: 5018
• Length: 273
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 131/374 - (35%)
• Similarity: 160/374 - (42%)
• Gaps: 134/374 - (35%)

  Fly   222 GKSTTGSNGFTSFSISSILSRSEPAKKNGAAGLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGA 286
            ||....:.|.:||:|.|||                         .|||.:|...
Human     8 GKGCPAAGGVSSFTIQSIL-------------------------GGGPSEAPRE----------- 36

  Fly   287 LAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPP-----SPTSMSPNNNNNNSNTTASSN 346
                     |.||| |.:|         |.|.::.|..|     :|....|:.:          .
Human    37 ---------PVGWP-ARKR---------SLSVSSEEEEPDDGWKAPACFCPDQH----------G 72

  Fly   347 QASKSPSHHPLHPLYHP-LGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSG-GG 409
            ...:.|.|||  |:..| ||                                 ||..|..|| ||
Human    73 PKEQGPKHHP--PIPFPCLG---------------------------------TPKGSGGSGPGG 102

  Fly   410 SSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSSPHGDGNSKR-----KK 469
            ...|    |.|:.||..:         .||.|.::.    ...||..|....||.::|     ||
Human   103 LERT----PFLSPSHSDF---------KEEKERLLP----AGSPSPGSERPRDGGAERQAGAAKK 150

  Fly   470 KTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAA 534
            ||||||||:||:|||||||:||||||||||.||:||:|||||||.|||||||||||||:|||||
Human   151 KTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEA- 214

  Fly   535 NMANMAHA-AQRLVRVPVLYHDGTTAGFVPPPPPHHHPMQYYAAARNTS 582
              |||||| ||.||.:|:::.|.:... ||.|.....|...|....|.|
Human   215 --ANMAHASAQTLVSMPLVFRDSSLLR-VPVPRSLAFPAPLYYPGSNLS 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	48/55 (87%)
HMX2	NP_005510.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..152		56/260 (22%)
		Homeodomain	150..206	CDD:459649	48/55 (87%)