Protein Alignment Hmx and HLX

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 102/411 - (24%)
• Similarity: 140/411 - (34%)
• Gaps: 146/411 - (35%)

  Fly   195 AAAAAAVAAANLSNNSNDSNGSSGGGGGKSTTGSNGF--TSFSISSILSRSEPAKKNGAAGLITP 257
            ||..|...|:|.|..|.....|:|.||..........  .||.|:.||        :...|.:..
Human     3 AAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADIL--------HAGVGDLGA 59

  Fly   258 IPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRYAALCPPGWPWAPQRLPFHSPTHDSSSTNTTE 322
            .|:    |..|...||:.:.||.:.                 |.|..:....||..
Human    60 APE----GLAGASAAALTAHLGSVH-----------------PHASFQAAARSPLR--------- 94

  Fly   323 NPPSPTSMSPNNNNNNSNTTASSNQASKSPSHHP--LHPLYHPLGSQQQQQQQQQHQQHPQQQQH 385
              |:|. ::|                |:.|:..|  |.||           ....|..||||||.
Human    95 --PTPV-VAP----------------SEVPAGFPQRLSPL-----------SAAYHHHHPQQQQQ 129

  Fly   386 PQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSS-----------SNESD-- 437
            .||.|||.|  |..|.:.:.....|.....|:||.:||...   |||           |.|.|
Human   130 QQQPQQQQP--PPPPRAGALQPPASGTRVVPNPHHSGSAPA---PSSKDLKFGIDRILSAEFDPK 189

  Fly   438 -EEGEEI---------------------------------IEEDDGTDGPSDSS----------- 457
             :||..:                                 |.|......|.:|:
Human   190 VKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQD 254

  Fly   458 ---SPHG-------DGNSKRKKK-TRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQ 511
               .|:.       ....|||:. :|.|||..|...||..|::::|::..:|..|||.|.||:.|
Human   255 TFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQ 319

  Fly   512 VKIWFQNRRNKWKRQLAAELE 532
            ||:||||||.||:....|:.:
Human   320 VKVWFQNRRMKWRHSKEAQAQ 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	27/56 (48%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		24/59 (41%)
		Homeodomain	273..333	CDD:459649	30/59 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		2/10 (20%)