DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmx and dlx3b

DIOPT Version :9

Sequence 1:	NP_001262674.1	Gene:	Hmx / 42110	FlyBaseID:	FBgn0264005	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_571397.2	Gene:	dlx3b / 30585	ZFINID:	ZDB-GENE-980526-280	Length:	269	Species:	Danio rerio

Alignment Length:	344	Identity:	79/344 - (22%)
Similarity:	123/344 - (35%)	Gaps:	118/344 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 PTHDSSSTNTTENPPSPTSMSPNNNNNNSNTTASSNQASKSPSHHPLHPLYHPLGSQQQQQQQQQ 375
            ||:|......:.:.....|..|.:.::.:...:|:.......|||                   :
Zfish     4 PTYDRKIPGISTDLSGSMSCHPTSKDSPTLPESSATDMGYYSSHH-------------------E 49

  Fly   376 HQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEG 440
            :.|.|     |..||....||.......::.|...:.|.:|: :....:|.|     :.:.....
Zfish    50 YYQSP-----PYPQQMNSYHQFNLSGMGATPGAYPTKTEYPY-NTYRQYGHY-----NRDLQTPP 103

  Fly   441 EEIIEEDDGTDGPSDSSSPHGDGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASL 505
            :..::|:..|:....:..|      |:.:|.||::|..|:..|:..|...:||:..|||.|||.|
Zfish   104 QSAVKEEPETEVRMVNGKP------KKIRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQL 162

  Fly   506 RLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQRLVRVPVLYHDGTTAGFVPPPPPHHH 570
            .||:|||||||||||:|:|:                          ||.:|..       |..|.
Zfish   163 GLTQTQVKIWFQNRRSKFKK--------------------------LYKNGEV-------PLEHS 194

  Fly   571 PMQYYAAARNTSP-------------------PRPPLSSLVXGVGCLATAPMSLLKPP------- 609
            |....:.|.|:.|                   |:|||||                .||
Zfish   195 PNASDSMACNSPPSPAVWDNNAHSSQVNRGQIPQPPLSS----------------TPPYMEDYSN 243

  Fly   610 ------NSMAHP-PHPQPP 621
                  :.:.|| .||.||
Zfish   244 HWYQQGSHLQHPVHHPGPP 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeobox	471..524	CDD:278475	29/52 (56%)
dlx3b	NP_571397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		6/36 (17%)
		DLL_N	28..104	CDD:289198	16/105 (15%)
		Homeobox	128..181	CDD:278475	29/52 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..242		13/66 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..269		6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D574097at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920