Protein Alignment Hmx and TLX3

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 101/400 - (25%)
• Similarity: 138/400 - (34%)
• Gaps: 165/400 - (41%)

  Fly   233 SFSISSILSR----SEPAKK--NGAAGLITPIPQLP--QPGAGGPQDAAMLSRLG--FISQWGAL 287
            ||.|..||:.    |.||.:  :||:.|..|    |  :|||..|...|..:.||  |..
Human    17 SFGIDQILNSPDQDSAPAPRGPDGASYLGGP----PGGRPGATYPSLPASFAGLGAPFED----- 72

  Fly   288 AGRYA---ALCPPGWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNNNNSNTTASSNQAS 349
            ||.|:   :|.|.|    ..|:|.|.|...:..      ||.|:::
Human    73 AGSYSVNLSLAPAG----VIRVPAHRPLPGAVP------PPLPSAL------------------- 108

  Fly   350 KSPSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSG------- 407
                                                        |..|:.||.||..|
Human   109 --------------------------------------------PAMPSVPTVSSLGGLNFPWME 129

  Fly   408 -----------GGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSSPHG 461
                       ..::||    |.......|:                               |:.
Human   130 SSRRFVKDRFTAAAALT----PFTVTRRIGH-------------------------------PYQ 159

  Fly   462 DGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQ 526
            :....::||.||.|||.|:.:||..|..::||:|:|||.||.||::|:.|||.||||||.||:||
Human   160 NRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQ 224

  Fly   527 LAAELEAANMANMAHAAQRLVRVPVLYHDGTTAGF---VPPPPPHHHPMQYYAAARNTSP----- 583
            .|.|.||..     ..|.||:.  .|.||......   :.|.|...|....: |.:|..|
Human   225 TAEEREAER-----QQASRLML--QLQHDAFQKSLNDSIQPDPLCLHNSSLF-ALQNLQPWEEDS 281

  Fly   584 -PRPPLSSLV 592
             ..|.::|||
Human   282 SKVPAVTSLV 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	33/55 (60%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		16/42 (38%)
		Homeodomain	167..223	CDD:459649	33/55 (60%)