Protein Alignment Hmx and tlx1

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_739571.1
• Gene: tlx1 / 266964
• ZFINID: ZDB-GENE-021021-2
• Length: 301
• Species: Danio rerio
• Alignment Length: 364
• Identity: 88/364 - (24%)
• Similarity: 136/364 - (37%)
• Gaps: 107/364 - (29%)

  Fly   233 SFSISSILSRSEPAKKNGAAGLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRYAALCPP 297
            ||.|..||:.::    .|:..:..|..|....|.|     .::|     :.:..:.|.|
Zfish    17 SFGIDQILNNAD----QGSCMITNPRMQDLDYGLG-----CIVS-----TAYNTMTGNY------ 61

  Fly   298 GWPWAPQRLPFHSPTHDSSSTNTTENPPSPTSMSPNNNNNNSNTTASSNQASKSPSHHPLHPLYH 362
                           :.::|:....|..|..|.:.|...|.:....:|:...:.|:|.||..::.
Zfish    62 ---------------NVNNSSGYNGNSCSVGSYNMNLGANVNGNCLNSSGVIRVPAHRPLGSVHS 111

  Fly   363 PLGSQQQQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGY 427
            .:                             |....|..|..|.|..::||....|.:
Zfish   112 SI-----------------------------PTSAATVPSMGSMGTINNLTGLTFPWM------- 140

  Fly   428 LLPSSSNESDEEGEEIIEEDDGTDGPSDSS------SPHGDGNSKRKKKTRTVFSRAQVFQLEST 486
                       |......:|..|...|..:      .|:.:....:|||.||.|:|.|:.:||..
Zfish   141 -----------ESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKR 194

  Fly   487 FDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEA----AN---MANMAHAAQ 544
            |..::||:|:|||.||.:|::|:.|||.||||||.||:||.|.|.||    ||   |.....|.|
Zfish   195 FHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILMQLQQEAFQ 259

  Fly   545 RLVRVPVLYHDGTTAGFVPPPPPHHHPMQYYAAARNTSP 583
            :.:..||          .|.|...|:...:  |.:|..|
Zfish   260 KTINQPV----------TPDPICLHNSSLF--ALQNLQP 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	31/55 (56%)
tlx1	NP_739571.1	Homeodomain	177..233	CDD:459649	31/55 (56%)