Protein Alignment Hmx and GBX1

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_001092304.1
• Gene: GBX1 / 2636
• HGNCID: 4185
• Length: 363
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 100/372 - (26%)
• Similarity: 147/372 - (39%)
• Gaps: 74/372 - (19%)

  Fly   215 GSSGGGGGKSTTGSNGFTSFSISSILSRSEPAKKNG------------AAGLITPIPQLPQP-GA 266
            |.:|||||    |..| |:|||.|::  ..|..::|            ...|:.|....|.| .|
Human    11 GGNGGGGG----GGPG-TAFSIDSLI--GPPPPRSGHLLYTGYPMFMPYRPLVLPQALAPAPLPA 68

  Fly   267 GGPQDAAMLSRLG-----FISQWGALAGRYAALC--------PPGWPWAPQRLPFHSPTHDSSST 318
            |.|..|.:.|..|     |.:..|.......||.        ||...:.||.|   :....:::.
Human    69 GLPPLAPLASFAGRLTNTFCAGLGQAVPSMVALTTALPSFAEPPDAFYGPQEL---AAAAAAAAA 130

  Fly   319 NTTENPPSPTSMSPNNNNNNSNTTASSNQASKSPSHHPLH-----PLYHPLGSQQQQQQQQQHQQ 378
            ....|.|.|....|...........:..:.::.|...|.|     |.....|......:::....
Human   131 TAARNNPEPGGRRPEGGLEADELLPAREKVAEPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEAS 195

  Fly   379 HPQQQQHPQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEI 443
            ........|:::.............||:||..:|. .|.|.|.||.|         ...|||..:
Human   196 AGDPAGSEQEEEGSGGDSEDDGFLDSSAGGPGALL-GPKPKLKGSLG---------TGAEEGAPV 250

  Fly   444 IEEDDGTDGPSDSSSPHGDGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLT 508
            ..   |...|.        |.|:|:   ||.|:..|:.:||..|..|:|||.:||:.:|.:|:|:
Human   251 TA---GVTAPG--------GKSRRR---RTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLS 301

  Fly   509 ETQVKIWFQNRRNKWKRQLAAELEAANMANMAHAAQR----LVRVPV 551
            |.||||||||||.||||     ::|.|:::.:....|    :|.:||
Human   302 EVQVKIWFQNRRAKWKR-----IKAGNVSSRSGEPVRNPKIVVPIPV 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	29/55 (53%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		13/24 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..265		29/160 (18%)
		Homeodomain	262..318	CDD:459649	30/58 (52%)