Protein Alignment Hmx and Nkx1-2

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_033149.1
• Gene: Nkx1-2 / 20231
• MGIID: 104806
• Length: 305
• Species: Mus musculus
• Alignment Length: 282
• Identity: 70/282 - (24%)
• Similarity: 107/282 - (37%)
• Gaps: 66/282 - (23%)

  Fly   362 HPLGSQQ-----------------QQQQQQQHQQHPQQQQHPQQQQQQHPHQPTTPTSSSSSGGG 409
            :|:|||:                 .:.::::..:...:...|::.|..|...|.....:..
Mouse    63 NPIGSQETPDAVGRGIDPGSPVEGSEAEEEEEAEDAGRAHQPERWQGVHEGSPEARAVAVG---- 123

  Fly   410 SSLTHHPHPHLTGSHGGYLLPSSSNESDEEGEEIIEEDDGTDGPSDSSSPHGDGNSKRKKKTRTV 474
                                      ::|.|.|.:....|:.|.........:.:..:.::.||.
Mouse   124 --------------------------TEESGAEGLPASPGSPGSPRPRRRRAESSCAKPRRARTA 162

  Fly   475 FSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANM 539
            |:..|:..||:.|...||||..||..||.||.||||||||||||||.|||:|    ...|:.|..
Mouse   163 FTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQ----NPGADGAVQ 223

  Fly   540 AHAAQRLVRVP--VLYHDGTTAGFVP-PPPPHHHPMQYYAAARNTSPPRP----PLSSLVXGVGC 597
            |.........|  |....|:..|..| ||.|...|.|.:.....|:...|    ||::.. |
Mouse   224 AGGGAPQPGTPGAVAGGGGSATGSSPGPPVPGALPYQTFPTYPATNVLFPAASFPLTTAANG--- 285

  Fly   598 LATAPMSLLKPPNSMA--HPPH 617
               :|.:....|:.:.  :.||
Mouse   286 ---SPFTPFLGPSYLTPFYAPH 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	33/55 (60%)
Nkx1-2	NP_033149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..158		13/124 (10%)
		Homeodomain	157..213	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..257		15/50 (30%)