Protein Alignment Hmx and Dbx

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_061502118.1
• Gene: Dbx / 1276399
• VectorBaseID: AGAMI1_014192
• Length: 727
• Species: Anopheles gambiae
• Alignment Length: 839
• Identity: 204/839 - (24%)
• Similarity: 262/839 - (31%)
• Gaps: 312/839 - (37%)

  Fly    26 RDSPLLARSPARSADGSSP-PATP--THRSNTPNTAAGTPTTSASGGNHFHHSPSGGAVPPAVLH 87
            :|||        |..|||| .|||  ||..      ||: ..|.|..:.|.......::..:...
Mosquito    18 KDSP--------SDHGSSPVHATPGATHGD------AGS-LASISDSDEFDEPKDSSSLCDSPKS 67

  Fly    88 HHLQHHLSSLGSHPVALHHALHTFGHLHPAHGATHPALLQHALTPTGQQQQQQLQVQQQHQQS-- 150
            .|..||.:|  .|.:.|||  |   |||  |...|.|||        .|||||.|.||.|..|
Mosquito    68 FHSLHHPAS--EHQLQLHH--H---HLH--HHHHHHALL--------VQQQQQQQHQQHHHNSSS 115

  Fly   151 ----HVERLSPP--MKSPERNGGDEVQGHSLNNNNSKALNHNNTCASAAAAAAAAAVAAANLSNN 209
                .:....||  :.:..|..|...:.|...:..:.....:..||......|....|||.
Mosquito   116 FSDDELPAAGPPVSLSAGVRRPGATFRAHPDPDGVAALEPMDFVCAKCGHCQADLNPAAAR---- 176

  Fly   210 SNDSNGS----SGGGGGKSTTGSN-------------------------------------GFTS 233
                :||    .|.|||....|.|                                     ||..
Mosquito   177 ----DGSPMVVGGDGGGDKRAGENNNNHSKEEEECDSVVTERRAGDGEGIGSEYEFRCEKCGFGE 237

  Fly   234 FSI---SSILSR-SEPAKKNGAAGLITPIPQLPQPGAGGPQDAAMLSRLGFISQWGALAGRYAAL 294
            :.:   .:||.. |:|..|...:.::            |.:...:..|..||.....
Mosquito   238 YVVPGKQTILKESSKPVLKFSVSAIL------------GDRKECVKVRNEFIQPQHL-------- 282

  Fly   295 CPPGWPWAPQRL--------PFHSPTHDSSSTNTTENPPSPTSMSPNNNNNNSNTTASSNQASKS 351
                ||:..|.|        |.....|       ..:|..|....|
Mosquito   283 ----WPYIQQNLIQQNHLANPAFLGAH-------PHHPHHPHQQLP------------------- 317

  Fly   352 PSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQH--------PQQQQQQH----PH------QPT 398
            |.||  ||.:||            |..||....|        |.||||||    |:      ..|
Mosquito   318 PHHH--HPHHHP------------HHHHPHHHHHQPGTHPLSPHQQQQQHLTVGPNGSPTGGHVT 368

  Fly   399 TPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEEGE-----EIIEEDDGTDGPSDS-- 456
            ..:||:.||||..    ||.||..|       :|||.:.|.|.     |:.|......||.|:
Mosquito   369 NNSSSNGSGGGGG----PHHHLHNS-------NSSNSTSESGSLPNSPELQEPSATGSGPRDNKI 422

  Fly   457 -----------------SSPH------------------------GD---------GNSKRKKKT 471
                             :.||                        |.         |..:|....
Mosquito   423 IAKPLPSRPTPFLHHSLNHPHLHSLLAHCRNPYMPGGPQVFPLPPGQGFPWAHSTRGKPRRGMMR 487

  Fly   472 RTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLAAELEAANM 536
            |.|||.:|...||..|.|::|:|..:|..||..|.|.::||||||||||.||:.....||    :
Mosquito   488 RAVFSDSQRKGLEKRFQLQKYISKPDRKKLAERLGLKDSQVKIWFQNRRMKWRNSKEREL----L 548

  Fly   537 ANMAHAAQRLVRV----PVLYHDGTTAGFVPPPPPHHHPMQYYAAARNTSPPRPPLSSLVXGVGC 597
            ||.....|.|...    |.|....|.......|||...|.|.........||:|
Mosquito   549 ANGGSRDQTLPNKNNPNPDLSDARTDRQTSLSPPPPASPPQGSTPHDGQPPPQP----------- 602

  Fly   598 LATAPMSLLKPPNSMAHPPH---PQPPPPAPLHMQQRSFLGCEQLTETDMDSDSEQERSHMMDDE 659
              |.|.:..||..: ||...   ||||||..|..:.:    .|.|..:.:..
Mosquito   603 --TTPSASPKPAPT-AHQQQGAAPQPPPPPMLTFKSK----FELLKPSAVAG------------- 647

  Fly   660 DAAIDVEADEEQESAS---------PV----PSATPPKSSLCLESKESGGQHKELAQGA 705
            .|..|.:.|.|.:.|.         |:    |.||.|...   ..:.:.....||..||
Mosquito   648 GAGADFKFDFEDQVAGGNRPPGGHFPMGGFYPGATDPAVG---SGRSNSSASSELQSGA 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	28/55 (51%)
Dbx	XP_061502118.1	None