Protein Alignment Hmx and DBX1

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_001025036.2
• Gene: DBX1 / 120237
• HGNCID: 33185
• Length: 343
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 91/412 - (22%)
• Similarity: 130/412 - (31%)
• Gaps: 156/412 - (37%)

  Fly   325 PSPTSMSPNN-----NNNNSNTTASSNQASKSPSHHPLHPLYHPLGSQQQQQQQQQHQQHPQQQQ 384
            |:||...|.:     :.::|.......:.|:.|::.|                    :..|....
Human    19 PTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPPAYLP--------------------RSVPTASM 63

  Fly   385 HPQQQQQQHPHQPTTPTSSSSSGGGSSLTHHPHPHLTGSHGGYLLPSSSNESDEE-----GEEII 444
            .|.:|     ..||..|.:.:|..||     |.|   ||..|...|::.:.:.|.     |...|
Human    64 SPPRQ-----GAPTALTDTGASDLGS-----PGP---GSRRGGSPPTAFSPASETTFLKFGVNAI 115

  Fly   445 EEDDGTDGPSDSSSP----------------HGD------------------------------G 463
            .    :.||...:||                .|.                              |
Human   116 L----SSGPRTETSPALLQSVPPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARG 176

  Fly   464 NSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLAASLRLTETQVKIWFQNRRNKWKRQLA 528
            ..:|....|.|||..|...||..|..::|:|..:|..|||.|.|.::||||||||||.||:....
Human   177 KPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKE 241

  Fly   529 AELEAANMANMAHAAQRLVRVPVLYHDGTTAGFVPP--------PPPHHHPMQYYAAARNTSPPR 585
            .||.::..........:|...|    |.:..|...|        |....|.:.|:|::
Human   242 RELLSSGGCREQTLPTKLNPHP----DLSDVGQKGPGNEEEEEGPGSPSHRLAYHASS------- 295

  Fly   586 PPLSSLVXGVGCLATAPMSLLKPPNSMAHPPHPQPPPPAPLHMQQRSFLGCEQLTETDMDSDSEQ 650
                                  .|..:..|..|.|.||:|.|.....       ..:|. ||||:
Human   296 ----------------------DPQHLRDPRLPGPLPPSPAHSSSPG-------KPSDF-SDSEE 330

  Fly   651 ERSHMMDDEDAAIDVEADEEQE 672
            |              |..||||
Human   331 E--------------EEGEEQE 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	28/55 (51%)
DBX1	NP_001025036.2	PRK12323	<49..182	CDD:481241	27/169 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..100		15/56 (27%)
		Homeodomain	184..238	CDD:459649	28/53 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..343		30/154 (19%)