Protein Alignment Hmx and nkx2-6

DIOPT Version :10

• Sequence 1: NP_001262674.1
• Gene: Hmx / 42110
• FlyBaseID: FBgn0264005
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: XP_002932599.1
• Gene: nkx2-6 / 100038094
• XenbaseID: XB-GENE-486951
• Length: 254
• Species: Xenopus tropicalis
• Alignment Length: 245
• Identity: 76/245 - (31%)
• Similarity: 105/245 - (42%)
• Gaps: 57/245 - (23%)

  Fly   397 PTTPTSSS-------SSG--GGSSLTHHP--HPHLTG------------SHGGYLLPSSSNESDE 438
            |.|.|..|       .:|  |.:.:..||  .|.|.|            |.|.:.      :|.:
 Frog     5 PATSTPFSVKDILRLENGQVGSAPVRSHPGTDPLLIGAARRDPIERDRESPGAFC------QSPQ 63

  Fly   439 -EGEEIIEEDDGTDGPSDSSSPHGDGNSKRKKKTRTVFSRAQVFQLESTFDLKRYLSSSERAGLA 502
             |..:..:|..|..|......|....:.::::|.|.:||:.|||:||..|..:||||:.||..||
 Frog    64 IEDPDFAQEQSGYFGGLGRGGPQEQLHHRQRRKPRVLFSQMQVFELERRFKQQRYLSAPEREQLA 128

  Fly   503 ASLRLTETQVKIWFQNRRNKWKRQLAAELEAANMANMAH-AAQRLVRVPVLYHD-----GTTAGF 561
            .:|:||.|||||||||||.|.|||     :......:.| ...|.|.||||..|     |.|..|
 Frog   129 LALKLTSTQVKIWFQNRRYKCKRQ-----KQDRSLELGHPIPPRRVAVPVLVRDGKPCLGPTQTF 188

  Fly   562 VPP----PPPHHHPM--------QYYAAARNTSPPRPPLSSLVXGVGCLA 599
            ..|    ..|:.:|:        .||:.|    |..|.:.|.: .:...|
 Frog   189 ASPYNVSATPYTYPVCYGNYTNSPYYSGA----PSVPTMGSQLISMNTTA 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmx	NP_001262674.1	Homeodomain	469..525	CDD:459649	33/55 (60%)
nkx2-6	XP_002932599.1	Homeodomain	95..151	CDD:459649	33/55 (60%)