Protein Alignment MEIS1 and achi

DIOPT Version :9

• Sequence 1: NP_002389.1
• Gene: MEIS1 / 4211
• HGNCID: 7000
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_001286352.1
• Gene: achi / 36373
• FlyBaseID: FBgn0033749
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 245
• Identity: 63/245 - (25%)
• Similarity: 97/245 - (39%)
• Gaps: 62/245 - (25%)

Human   158 ELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSK--SDSEDITRSANLTDQPSWNRDHDDT 220
            |.|:|:.:.|....:.|..:..:..:...:.:.||..:  |||.        .||.|.:.|
  Fly     5 EQEEVNMVLDRHVRQNIQDMMHEAHVQASLLENEGRGRFHSDSS--------LDQDSLHAD---- 57

Human   221 ASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATN 285
                            .....|.|:|.|.....:........:...|.:....|:||..||.:..
  Fly    58 ----------------VIVEEDQSTEHGANQVQNYHDMMVDSEHHIDINGSLRKRRGNLPKTSVK 106

Human   286 IMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQS------------ 338
            |::.||::|..:.|||:.:|..|:|:..||:|||.||||||||||:..||.:.
  Fly   107 ILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTISRR 171

Human   339 --------NRAVSQG---TPYNP-DGQPMGGFVMD--------GQQHMGI 368
                    :|:.:.|   |..|| .|.|....|:.        |:.|.||
  Fly   172 GKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDGAGEIHEGI 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEIS1	NP_002389.1	Meis_PKNOX_N	108..192	CDD:406806	5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..279		17/90 (19%)
		Homeobox_KN	290..329	CDD:399131	21/38 (55%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|PubMed:28473536	299..329		18/29 (62%)
		Required for transcriptional activation. /evidence=ECO:0000250	335..390		13/66 (20%)
achi	NP_001286352.1	Homeobox_KN	111..150	CDD:283551	21/38 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830