Protein Alignment Prx3 and PRDX6

DIOPT Version :10

• Sequence 1: NP_524387.1
• Gene: Prx3 / 42109
• FlyBaseID: FBgn0038519
• Length: 234
• Species: Drosophila melanogaster
• Sequence 2: NP_004896.1
• Gene: PRDX6 / 9588
• HGNCID: 16753
• Length: 224
• Species: Homo sapiens
• Alignment Length: 203
• Identity: 53/203 - (26%)
• Similarity: 98/203 - (48%)
• Gaps: 25/203 - (12%)

  Fly    46 APDFKGLAVVDNSFQEVKLEDYRG-KYLVLFFYPLDFTFVCPTEIVAFSERIKEFHDINTEVLGV 109
            ||:|:....|.    .::..|:.| .:.:||.:|.|||.||.||:...::...||...|.:::.:
Human    11 APNFEANTTVG----RIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIAL 71

  Fly   110 SVDSHFSHLTW---CNVDRKNGGVGQLKYPLLSDLTKKISADYDVLL--------DKEG--ISLR 161
            |:||...||.|   .|.........:|.:|::.|..::::    :||        |::|  ::.|
Human    72 SIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELA----ILLGMLDPAEKDEKGMPVTAR 132

  Fly   162 GTFIIDPNGILRQYSINDLPVGRSVDEVLRLIKAFQFVEQHGEVCPANWNPNSNPATIKPDV--E 224
            ..|:..|:..|:...:.....||:.||:||::.:.|...:.....|.:|. :.:...:.|.:  |
Human   133 VVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWK-DGDSVMVLPTIPEE 196

  Fly   225 ESKKYFSK 232
            |:||.|.|
Human   197 EAKKLFPK 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prx3	NP_524387.1	PRX_Typ2cys	42..212	CDD:239313	46/179 (26%)
		1-cysPrx_C	195..232	CDD:431271	9/38 (24%)
PRDX6	NP_004896.1	PRX_1cys	7..222	CDD:239314	53/203 (26%)
		Required and sufficient for targeting to lysosomes and lamellar bodies. /evidence=ECO:0000250|UniProtKB:O35244	31..40		2/8 (25%)