DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prx3 and PRDX3

DIOPT Version :9

Sequence 1:	NP_524387.1	Gene:	Prx3 / 42109	FlyBaseID:	FBgn0038519	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	NP_006784.1	Gene:	PRDX3 / 10935	HGNCID:	9354	Length:	256	Species:	Homo sapiens

Alignment Length:	205	Identity:	131/205 - (63%)
Similarity:	160/205 - (78%)	Gaps:	2/205 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ARLLHQTAPLAAVRVQQPAPDFKGLAVVDNSFQEVKLEDYRGKYLVLFFYPLDFTFVCPTEIVAF 92
            |:|...::...|..|.|.||.|||.|||:..|:::.|:|::||||||||||||||||||||||||
Human    51 AKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAF 115

  Fly    93 SERIKEFHDINTEVLGVSVDSHFSHLTWCNVDRKNGGVGQLKYPLLSDLTKKISADYDVLLDKEG 157
            |::..||||:|.||:.||||||||||.|.|..|||||:|.:...|||||||:||.||.|||:..|
Human   116 SDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSG 180

  Fly   158 ISLRGTFIIDPNGILRQYSINDLPVGRSVDEVLRLIKAFQFVEQHGEVCPANWNPNSNPATIKPD 222
            ::|||.|||||||:::..|:|||||||||:|.|||:||||:||.|||||||||.|:|  .||||.
Human   181 LALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDS--PTIKPS 243

  Fly   223 VEESKKYFSK 232
            ...||:||.|
Human   244 PAASKEYFQK 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prx3	NP_524387.1	AhpC	40..233	CDD:223527	128/193 (66%)
		PRX_Typ2cys	42..212	CDD:239313	117/169 (69%)
		1-cysPrx_C	195..232	CDD:287400	24/36 (67%)
PRDX3	NP_006784.1	PRX_Typ2cys	65..236	CDD:239313	117/170 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3230
eggNOG	1	0.900	-	-		E1_COG0450
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4944
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2982
Isobase	1	0.950	-	0	Normalized mean entropy	S305
OMA	1	1.010	-	-		QHG54000
OrthoDB	1	1.010	-	-		D1326484at2759
OrthoFinder	1	1.000	-	-		FOG0000434
OrthoInspector	1	1.000	-	-		oto89279
orthoMCL	1	0.900	-	-		OOG6_100111
Panther	1	1.100	-	-	LDO	PTHR42801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6659
SonicParanoid	1	1.000	-	-		X272
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820