DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P5cr-2 and PYCR1

DIOPT Version :9

Sequence 1:	NP_650632.1	Gene:	P5cr-2 / 42106	FlyBaseID:	FBgn0038516	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_001269210.1	Gene:	PYCR1 / 5831	HGNCID:	9721	Length:	346	Species:	Homo sapiens

Alignment Length:	279	Identity:	123/279 - (44%)
Similarity:	173/279 - (62%)	Gaps:	11/279 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAIGK-------IGFLGGGNMAKALAKGFLAAGLAKPNTLIASVHPADKLSLQSFQSLGVETVI 58
            :.|:|:       :||:|.|.:|.||||||.|||:...:.::||....|..::.:.:.:||:...
Human    17 VGALGQGSPDSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTP 81

  Fly    59 KNAPVVQQSDVVFVSVKPQVVPSVLSEI-QPLSSGKLFLSVAMGITLSTIESSLS---PQARVIR 119
            .|...||.|||:|::|||.::|.:|.|| ..:....:.:|.|.|:|:|:||..||   |..||||
Human    82 HNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIR 146

  Fly   120 VMPNLPAVVCSGCSVFVRGSKATDADADITQKLLQSVGTCEPVDESQLDVVTALSGSGPAYVFVM 184
            .|.|.|.||..|.:|:..|:.|...|..:.::||.|||.|..|:|..:|.||.||||||||.|..
Human   147 CMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTA 211

  Fly   185 IEALADGAVHMGMPRDLAYRLASQTVLGAGHMVRDSGMHPGQLKDGVTSPAGSTAAALRQLELSG 249
            ::|||||.|.||:||.||.||.:|.:|||..|:..|..|||||||.|:||.|:|..||..||..|
Human   212 LDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGG 276

  Fly   250 FRAAVSGAVEQATLRCRQI 268
            ||:.:..|||.:.:|.|::
Human   277 FRSLLINAVEASCIRTREL 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P5cr-2	NP_650632.1	PLN02688	6..270	CDD:178291	121/274 (44%)
		F420_oxidored	8..101	CDD:281759	35/93 (38%)
		P5CR_dimer	163..267	CDD:291418	56/103 (54%)
PYCR1	NP_001269210.1	P5CR_dimer	28..295	CDD:330785	121/266 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9449
eggNOG	1	0.900	-	-		E1_COG0345
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3499
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60612
OrthoDB	1	1.010	-	-		D581707at33208
OrthoFinder	1	1.000	-	-		FOG0001010
OrthoInspector	1	1.000	-	-		otm42074
orthoMCL	1	0.900	-	-		OOG6_100382
Panther	1	1.100	-	-	LDO	PTHR11645
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R884
SonicParanoid	1	1.000	-	-		X667
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910