DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and LRIG2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_055628.1 Gene:LRIG2 / 9860 HGNCID:20889 Length:1065 Species:Homo sapiens


Alignment Length:859 Identity:171/859 - (19%)
Similarity:278/859 - (32%) Gaps:261/859 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 FLAQYYRTDV--HEATYRCRASNEAG---TVLSRNV----QVHAVVRRQF-------HVHVENT- 147
            ||:.....|:  :|.::....::||.   |.|::.:    |:.::.::.|       |:.:.|. 
Human   357 FLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNA 421

  Fly   148 ---------------EVYLGNSAL-----------------------IKCAIPEYVRPYVRVASW 174
                           |:.|..|:|                       :.||.||          |
Human   422 IMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPE----------W 476

  Fly   175 HRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKE 239
            ..|:.||..||.|                           |.|             |..:     
Human   477 LAGQSILNVDLKD---------------------------FVC-------------DDFL----- 496

  Fly   240 LSKNLAPRTTQKPVMEIHVE-----RGNDVHLPCN-IQGNPFPIFTWYRVSDSAALYPIPSSQRV 298
                       ||.:..|.|     ||.:|.|.|. :..:..|:.|.:| .||..||.:.:...|
Human   497 -----------KPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWR-KDSEILYDVDTENFV 549

  Fly   299 --------ILSRTLLL-IKNADERDAGKWICQASNQFGEQRIE-IRLSVNSYVSVHILPQVQIVN 353
                    .|..|.:| :.|.:..|.||:.|..:|.||....: .:|:||...|....|....:.
Human   550 RYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIR 614

  Fly   354 SGGTANFNCTTTGSAIDAIDWLHNGK---PLQANNAL-TTGRDNIRFLSKSSLLVQNVGRRDRGV 414
            :|..|...|...|.....|.|..:|.   |......: ....|::.|::       ||...|.|:
Human   615 TGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIA-------NVKIEDMGI 672

  Fly   415 YQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPI 479
            |.|:.:|......|.|.|.:.:| |..|....::.|..|....|:|.|.|||.|:..|..|..|:
Human   673 YSCMAQNTAGGLSANASLTVLET-PSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPL 736

  Fly   480 MDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRA 544
            :....|...|..|.          |.|.....:|.|.|.|:.||::|:.:....|||...|  ..
Human   737 LVTERHFFAAANQL----------LIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP--NC 789

  Fly   545 IGPIKAVAGED----------IIVHCPFAGYPVEQIRW-------EKAHQELTTSNHYELASVAD 592
            .....::..||          |:|.|...|   ..:.|       .:.:::.:.:|..||...||
Human   790 DSSQSSIGHEDDGWTTVGIVIIVVVCCVVG---TSLIWVIVIYHMRRKNEDYSITNTEELNLPAD 851

  Fly   593 GGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPV---IEPFKFPKNLQEGGRAQIT 654
            ....:       ..||..:......:..||....||   .||.   |.     |....|...::.
Human   852 IPSYL-------SSQGTLSEPQEGYSNSEAGSHQQL---MPPANGYIH-----KGTDGGTGTRVI 901

  Fly   655 CAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEF--YSLLVFKDISARHSGKYTCYASNAAAKVN 717
            |:....:..||                 .:..|:  |:.:..:|:                  ::
Human   902 CSDCYDNANIY-----------------SRTREYCPYTYIAEEDV------------------LD 931

  Fly   718 YT-AELQVRVAPRWRY---EPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMR 778
            .| :.|.|:: |:..|   .|.||..:.....|.|.|...:|.      ..:....|......|.
Human   932 QTLSSLMVQM-PKETYLVHPPQDTTALESLIPSANREPSAFPT------NHERISEKKLPSTQMS 989

  Fly   779 NHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRND--PVTLDCH 841
            ..:|...:...|          .|:|.......:..|:|..:..|: ..::.|..|  ..::.||
Human   990 GETLQRPVWNIN----------RELGLPHPPFSQQPVHESPQLHQN-EGLAGREPDCSASSMSCH 1043

  Fly   842 AKGDEPITIGWTQN 855
            ...|.......|:|
Human  1044 RLQDHAFDFSRTRN 1057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 9/41 (22%)
Ig 56..125 CDD:143165 6/29 (21%)
I-set 246..337 CDD:254352 29/106 (27%)
Ig 264..334 CDD:143165 22/80 (28%)
I-set 345..433 CDD:254352 20/91 (22%)
Ig 358..431 CDD:143165 17/76 (22%)
Ig 456..533 CDD:143165 22/76 (29%)
IGc2 553..619 CDD:197706 14/82 (17%)
I-set 634..724 CDD:254352 12/95 (13%)
ig 645..712 CDD:278476 7/68 (10%)
IG_like 734..815 CDD:214653 13/80 (16%)
Ig 745..815 CDD:299845 10/69 (14%)
I-set 820..913 CDD:254352 8/38 (21%)
Ig 838..920 CDD:299845 5/18 (28%)
FN3 917..1033 CDD:238020
FN3 1040..1142 CDD:238020
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
LRIG2NP_055628.1 LRR_RI <46..205 CDD:238064
LRR 1 76..97
LRR 2 98..119
leucine-rich repeat 99..121 CDD:275380
LRR_8 120..179 CDD:290566
LRR 3 121..142
leucine-rich repeat 122..145 CDD:275378
LRR 4 145..166
leucine-rich repeat 146..168 CDD:275380
LRR_8 168..251 CDD:290566
LRR 5 168..189
leucine-rich repeat 169..192 CDD:275380
LRR 6 193..214
leucine-rich repeat 194..216 CDD:275380
LRR 7 216..237
leucine-rich repeat 217..240 CDD:275380
LRR_8 240..299 CDD:290566
LRR 8 240..261
leucine-rich repeat 241..264 CDD:275380
LRR 9 264..285
leucine-rich repeat 265..288 CDD:275380
LRR_RI 266..492 CDD:238064 28/171 (16%)
LRR 10 288..309
leucine-rich repeat 289..312 CDD:275380
LRR_8 312..371 CDD:290566 3/13 (23%)
LRR 11 312..333
leucine-rich repeat 313..336 CDD:275380
LRR 12 336..357 171/859 (20%)
leucine-rich repeat 337..360 CDD:275380 2/2 (100%)
LRR_8 359..422 CDD:290566 10/62 (16%)
LRR 13 360..382 3/21 (14%)
leucine-rich repeat 361..385 CDD:275380 4/23 (17%)
LRR 14 387..408 3/20 (15%)
leucine-rich repeat 388..411 CDD:275380 3/22 (14%)
LRR 15 411..432 2/20 (10%)
leucine-rich repeat 412..434 CDD:275380 2/21 (10%)
LRRCT 445..493 CDD:214507 14/97 (14%)
Ig 502..598 CDD:299845 27/96 (28%)
IG 504..598 CDD:214652 26/94 (28%)
I-set 602..692 CDD:254352 22/96 (23%)
Ig_1 619..693 CDD:143240 19/80 (24%)
I-set 696..783 CDD:254352 27/96 (28%)
Ig 714..783 CDD:299845 23/78 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..990 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1003..1040 7/37 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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