DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and CD22

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001762.2	Gene:	CD22 / 933	HGNCID:	1643	Length:	847	Species:	Homo sapiens

Alignment Length:	895	Identity:	205/895 - (22%)
Similarity:	316/895 - (35%)	Gaps:	244/895 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QVHA-VVRRQFHVHVE-NTEVYLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYV 193
            ::|. |..|.|..|:: ..|:.......:.|.:......|.....|.         |..|..|..
Human   131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWL---------LEGVPMRQA 186

  Fly   194 VLAASGDLYVRSV--RSEDGLMKFS-------CLVTNTL---NGERQRSDAVMLQVKELSKNLAP 246
            .: .|..|.::||  |||   :|||       .:||..|   :|:...:|.|.|.||...| |..
Human   187 AV-TSTSLTIKSVFTRSE---LKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-LEI 246

  Fly   247 RTTQKPVMEIHVERGNDVHLPCNI-QGNP-FPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKN 309
            :.|....:   |..|:.|.:.|.: ..|| :...:|  :.|..:|    ..|...    .|.::.
Human   247 KVTPSDAI---VREGDSVTMTCEVSSSNPEYTTVSW--LKDGTSL----KKQNTF----TLNLRE 298

  Fly   310 ADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQ---VQIVNS----GGTANFNCTTTGS 367
            ..:..:||:.||.||..|..|.|     ..::.|...|:   |||::|    |....|.|.:..:
Human   299 VTKDQSGKYCCQVSNDVGPGRSE-----EVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLAN 358

  Fly   368 AIDA-IDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAE 431
            .:.. ..|.||||.:|       ||      ::..:.:..:.....|.|.|:.||...:.|....
Human   359 PLPTNYTWYHNGKEMQ-------GR------TEEKVHIPKILPWHAGTYSCVAENILGTGQRGPG 410

  Fly   432 LKLGDTVPELIYTFIEQN---VRPGPLISLKCSASGSPP--------PQFAWLLDSQPIMDVSLH 485
            .:|....|....|.:.||   :|.|..::|.|:.:.|.|        |..||   .:|.:.|
Human   411 AELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW---EEPSLGV--- 469

  Fly   486 HRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNV-YGP--PYVRAIGP 547
                              |.|.:|..|:..: .|.|.||..|......||| |.|  ..||.|.|
Human   470 ------------------LKIQNVGWDNTTI-ACAACNSWCSWASPVALNVQYAPRDVRVRKIKP 515

  Fly   548 IKAV-AGEDIIVHCPF-AGYPVE-QIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGI 609
            :..: :|..:.:.|.| :.:|.| |..|||..:.|...:           ||...::.| .|.|.
Human   516 LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKES-----------QLNFDSISP-EDAGS 568

  Fly   610 YTCIVRSRAGEEARRDMQLNV-NSPPVIEPFKFP-KNLQEGGRAQITCAVSSGDMPI----YFSW 668
            |:|.|.:..|:.|.:...|.| .:|..:.....| ..:.||..|.:||. |..:.|:    :|.|
Human   569 YSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCE-SDANPPVSHYTWFDW 632

  Fly   669 KKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAK---------VNYTAELQV 724
              ::.|:|...|          .|..:.:..:|||.|.|..:|:..|         |.|:.|...
Human   633 --NNQSLPYHSQ----------KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIG 685

  Fly   725 RVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATD 789
            |          ..|:.||:.::|       .|..|...|.|.:..:                 |.
Human   686 R----------RVAVGLGSCLAI-------LILAICGLKLQRRWKR-----------------TQ 716

  Fly   790 NDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQ 854
            :.:|.....:........||..|..::|                .|.:|.|:    .|:     .
Human   717 SQQGLQENSSGQSFFVRNKKVRRAPLSE----------------GPHSLGCY----NPM-----M 756

  Fly   855 NNGRIDLNNFRFSIAEM---KTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQER 916
            .:| |.....||  .||   :|.....|::.....|..|:..|..:.:...|..|.:|
Human   757 EDG-ISYTTLRF--PEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVI------- 811

  Fly   917 PDTP-------SHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKY 959
            ||.|       |.|..|.||.|              |.....|.|..||:
Human   812 PDFPEDEGIHYSELIQFGVGER--------------PQAQENVDYVILKH 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	0/1 (0%)
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	21/92 (23%)
		Ig	264..334	CDD:143165	18/71 (25%)
		I-set	345..433	CDD:254352	22/95 (23%)
		Ig	358..431	CDD:143165	16/73 (22%)
		Ig	456..533	CDD:143165	18/84 (21%)
		IGc2	553..619	CDD:197706	18/67 (27%)
		I-set	634..724	CDD:254352	24/103 (23%)
		ig	645..712	CDD:278476	18/70 (26%)
		IG_like	734..815	CDD:214653	13/80 (16%)
		Ig	745..815	CDD:299845	10/69 (14%)
		I-set	820..913	CDD:254352	18/95 (19%)
		Ig	838..920	CDD:299845	19/84 (23%)
		FN3	917..1033	CDD:238020	14/50 (28%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
CD22	NP_001762.2	Ig	24..122	CDD:299845
		C2-set_2	143..228	CDD:285423	22/97 (23%)
		I-set	242..327	CDD:254352	23/103 (22%)
		IGc2	257..316	CDD:197706	16/68 (24%)
		Ig_3	335..400	CDD:290638	18/77 (23%)
		IG_like	343..415	CDD:214653	18/84 (21%)
		IG_like	433..501	CDD:214653	21/92 (23%)
		I-set	510..589	CDD:254352	25/90 (28%)
		IGc2	521..578	CDD:197706	18/68 (26%)
		IG_like	606..677	CDD:214653	20/83 (24%)
		IGc2	608..666	CDD:197706	19/70 (27%)
		ITIM motif 1	760..765		1/4 (25%)
		ITIM motif 2	794..799		1/4 (25%)
		ITIM motif 3	820..825		1/4 (25%)
		ITIM motif 4	840..845		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910