DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and IL18RAP

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001380415.1	Gene:	IL18RAP / 8807	HGNCID:	5989	Length:	599	Species:	Homo sapiens

Alignment Length:	705	Identity:	142/705 - (20%)
Similarity:	229/705 - (32%)	Gaps:	243/705 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVH 265
            |:..|.|||:..:.|..|      .|.|:|..       ..:|   |.:.|.|.|         |
Human    31 LWTYSTRSEEEFVLFCDL------PEPQKSHF-------CHRN---RLSPKQVPE---------H 70

  Fly   266 LPCNIQGNPFPIFTWYR-------VSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQ-- 321
            ||. :..|......||:       :.|....||     .:|..:..|........::|.:||:
Human    71 LPF-MGSNDLSDVQWYQQPSNGDPLEDIRKSYP-----HIIQDKCTLHFLTPGVNNSGSYICRPK 129

  Fly   322 -ASNQFG-----EQRIEIRLSVNS---YVSVHILPQVQIVNSGGTANFNCTTTGSAID----AID 373
             ..:.:.     :..:|::...|:   |.:.|    .|.:..|.|.:.:|.:.....|    |:.
Human   130 MIKSPYDVACCVKMILEVKPQTNASCEYSASH----KQDLLLGSTGSISCPSLSCQSDAQSPAVT 190

  Fly   374 WLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQC------LVENQRASAQAMAEL 432
            |..|||      .|:..|.|       .::|..|....:|.|.|      .|.:....|......
Human   191 WYKNGK------LLSVERSN-------RIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRT 242

  Fly   433 KLGDT--VPELIYTFIEQ--NVRPGPLISLKCSASGSPP----PQFAWLL-DSQPIMDVSLHHRF 488
            .:|||  .|:::.. :|.  .|..|..:::.|.|.....    |...|.: ||....:||:....
Human   243 IVGDTKLKPDILDP-VEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAK 306

  Fly   489 AIGQFVDMSGDVISHLNISHVRPDDGGL---YKCVASNSMGSVQHSARLN-------VYGPPYVR 543
            :|...:.   |.|...||...:.....|   :.|...||:|:...|.:|.       :|  ..:.
Human   307 SIKSTLK---DEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLY--ILLG 366

  Fly   544 AIGPIKAVAG----------EDIIVHCPFAGYP------------VEQIRWEKAHQELTTS---N 583
            .||.:.||..          |.::::..:....            |...:|.....|.|:|   .
Human   367 TIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEE 431

  Fly   584 HYELASVAD------GGQLVI--KNVEPGRDQGIY-----TCIVRSRAGEEARRDMQLN-VNSPP 634
            |..|:...|      |..|.:  ::|.||   |:|     :.|.|||.|...   :..| ||.|.
Human   432 HLALSLFPDVLENKYGYSLCLLERDVAPG---GVYAEDIVSIIKRSRRGIFI---LSPNYVNGPS 490

  Fly   635 VIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISA 699
            :.|       ||    |.:..|:             ||.::              .|::.|
Human   491 IFE-------LQ----AAVNLAL-------------DDQTL--------------KLILIK---- 513

  Fly   700 RHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKG 764
                  .||..                      ||.....::...:.:        :||:||
Human   514 ------FCYFQ----------------------EPESLPHLVKKALRV--------LPTVTW--- 539

  Fly   765 QGKGSKDFKPLS-----MRNHSLLLNLATDNDEGYYMCQ--ATNEI--GAGLKKT 810
              :|.|...|.|     ||.|     :...|.:|:...|  .|:.|  ..||.:|
Human   540 --RGLKSVPPNSRFWAKMRYH-----MPVKNSQGFTWNQLRITSRIFQWKGLSRT 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	19/105 (18%)
		Ig	264..334	CDD:143165	15/84 (18%)
		I-set	345..433	CDD:254352	20/97 (21%)
		Ig	358..431	CDD:143165	17/82 (21%)
		Ig	456..533	CDD:143165	19/84 (23%)
		IGc2	553..619	CDD:197706	20/103 (19%)
		I-set	634..724	CDD:254352	11/89 (12%)
		ig	645..712	CDD:278476	10/66 (15%)
		IG_like	734..815	CDD:214653	20/86 (23%)
		Ig	745..815	CDD:299845	19/75 (25%)
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
IL18RAP	NP_001380415.1	Ig_6	100..155	CDD:408247	9/59 (15%)
		Ig	162..>221	CDD:416386	17/71 (24%)
		Ig strand A	162..166	CDD:409353	1/3 (33%)
		Ig strand B	171..175	CDD:409353	0/3 (0%)
		Ig strand C	188..193	CDD:409353	2/4 (50%)
		Ig strand C'	196..198	CDD:409353	1/7 (14%)
		Ig strand E	204..209	CDD:409353	1/11 (9%)
		Ig	251..354	CDD:416386	24/106 (23%)
		Ig strand A	251..254	CDD:409353	1/2 (50%)
		Ig strand A'	262..265	CDD:409353	1/2 (50%)
		Ig strand B	267..276	CDD:409353	1/8 (13%)
		Ig strand C	285..290	CDD:409353	1/4 (25%)
		Ig strand D	300..308	CDD:409353	2/7 (29%)
		Ig strand E	315..323	CDD:409353	3/7 (43%)
		Ig strand F	334..340	CDD:409353	1/5 (20%)
		Ig strand G	344..350	CDD:409353	1/5 (20%)
		TIR	419..559	CDD:396246	46/233 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910