DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	791	Identity:	174/791 - (21%)
Similarity:	297/791 - (37%)	Gaps:	164/791 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 LSKSSLLVQ--NVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQN----VRPGPL 455
            ::.|.|.:|  .:|.:.||.  |||...      ||:.|........:|:|.:|.    |..|..
Human    14 IASSPLRMQQNELGLQKRGC--CLVLGY------MAKDKFRRMNEGQVYSFSQQPQDQVVVSGQP 70

  Fly   456 ISLKCSASGSPPPQF----AWLLDSQPI---MDVSLHHRF-AIGQFVDMSGDVISHLNISHVRPD 512
            ::|.|:.     |::    .|:.|...:   .|:|.:.:: .:|.  .:||:  .||.|......
Human    71 VTLLCAI-----PEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGN--HLSGE--HHLKILRAELQ 126

  Fly   513 DGGLYKCVASNSMGSVQHSARLNVYGPPYVRAI--GPIKAV-AGEDIIVHC-PFAGYPVEQIRWE 573
            |..:|:|.|..: ......|||.|..||....|  ||:.:: ||:.:.:.| .....|...|.|.
Human   127 DDAVYECQAIQA-AIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIWL 190

  Fly   574 KAHQELTTSNHYELASVADGGQLVIKN---VEPG---RDQGIYTCIVRSRA---GEEARRDMQLN 629
            : ..|:.....|....:.||.:..|.:   :.||   ..|.| .|...::|   |:|.  .:.::
Human   191 R-KGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSI-VCRATNKAIPGGKET--SVTID 251

  Fly   630 VNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVF 694
            :..||::.....|:.:.|.......|:..:......:.|.|....      |.|...|.|...|
Human   252 IQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQI------IKEASGEVYRTTV- 309

  Fly   695 KDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTI 759
             |.: ..|...:|..:||....|.:..:.|...||...||....:.||:....:|...|.|..||
Human   310 -DYT-YFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTI 372

  Fly   760 TWFK-GQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQA-TNEIGAGLKKTIRINVNEPARFE 822
            .|.| |.|....:.|.|::::       ....|.|.|:|:| ...:||| ::.:.:.||.|. ..
Human   373 VWMKRGSGVVLSNEKTLTLKS-------VRQEDAGKYVCRAVVPRVGAG-EREVTLTVNGPP-II 428

  Fly   823 QSARNISSRRNDPVTLDCHAKGDEP---ITIGWTQN---NGRIDLNNFRFSIAEMKTEKGVDSQL 881
            .|.:...:...:...:.|..:...|   |...|.:|   :|    .:.|:::..:.||:||.|.|
Human   429 SSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESG----TSGRYTVETISTEEGVISTL 489

  Fly   882 TIGHSDRHD-SGVYRCIAENPYGRAEQIIFLAVQ----------ERPDTPSHLEI-FEVGSRTVK 934
            ||.:..|.| ..:|.|.|.|.:|...:||.|..|          |....|..:.| ..||:....
Human   490 TISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAF 554

  Fly   935 LSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESA 999
            |          .:::.:|.:...:..:|.|..:...|........:.||             ..|
Human   555 L----------VLMATIVAFCCARSQRSTGGRSGISGRGTEKKARLRLP-------------RRA 596

  Fly  1000 IVAGLTPATTFLIRMQAINE------------------IERSAYTEAIVLKTQEEAPTEAP--SN 1044
            .:.|:..|... ||::.:::                  ::|..:.:..|||..|....|..  .|
Human   597 NLKGVVSAKND-IRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQN 660

  Fly  1045 VQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISV------VNSSLKSTIVSGW 1103
            ::..|.|.                     |:||..:|..:...||:      :..:.|..:.:|.
Human   661 LKDPTNGY---------------------YSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGM 704

  Fly  1104 ATTK--ATLRG 1112
            :.|.  :||.|
Human   705 SFTNIYSTLSG 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	11/37 (30%)
		Ig	358..431	CDD:143165	10/35 (29%)
		Ig	456..533	CDD:143165	17/84 (20%)
		IGc2	553..619	CDD:197706	16/75 (21%)
		I-set	634..724	CDD:254352	17/89 (19%)
		ig	645..712	CDD:278476	12/66 (18%)
		IG_like	734..815	CDD:214653	22/82 (27%)
		Ig	745..815	CDD:299845	19/71 (27%)
		I-set	820..913	CDD:254352	26/99 (26%)
		Ig	838..920	CDD:299845	27/98 (28%)
		FN3	917..1033	CDD:238020	19/134 (14%)
		FN3	1040..1142	CDD:238020	16/83 (19%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	23/100 (23%)
		IG_like	60..149	CDD:214653	22/98 (22%)
		I-set	156..249	CDD:254352	22/96 (23%)
		Ig2_KIRREL3-like	171..252	CDD:143236	17/84 (20%)
		Ig_2	260..337	CDD:290606	16/85 (19%)
		I-set	341..422	CDD:254352	25/88 (28%)
		IGc2	355..406	CDD:197706	16/57 (28%)
		Ig5_KIRREL3	424..521	CDD:143306	26/101 (26%)
		IG_like	432..521	CDD:214653	24/92 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810