DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and KIRREL2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_954649.3 Gene:KIRREL2 / 84063 HGNCID:18816 Length:708 Species:Homo sapiens


Alignment Length:722 Identity:157/722 - (21%)
Similarity:236/722 - (32%) Gaps:219/722 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 ENTEVYLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAG--RYVVL--AASG--DLYV 203
            |:..|.||..|.:.||:    ..|..:..|.: ..:.|....|:.|  ||.:.  ||:|  ||::
Human    31 EDLVVLLGEEARLPCAL----GAYWGLVQWTK-SGLALGGQRDLPGWSRYWISGNAANGQHDLHI 90

  Fly   204 RSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPC 268
            |.|..||. ..:.|..|..  |.|.|.    .|:..|....||:....|  .:.:..|...:|.|
Human    91 RPVELEDE-ASYECQATQA--GLRSRP----AQLHVLVPPEAPQVLGGP--SVSLVAGVPANLTC 146

  Fly   269 NIQGN--PFPIFTWYR---VSDSAALYP------IPSSQRVILSRTLLLIKNADERDAGKWICQA 322
            ..:|:  |.|...|:|   :.|.|..:.      .|.|    :..||.|...:.: |...::|:|
Human   147 RSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGS----VESTLTLTPFSHD-DGATFVCRA 206

  Fly   323 SNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNAL 387
            .:|                                                            ||
Human   207 RSQ------------------------------------------------------------AL 211

  Fly   388 TTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRP 452
            .||||....||..              |.                      ||:..:.....|:.
Human   212 PTGRDTAITLSLQ--------------YP----------------------PEVTLSASPHTVQE 240

  Fly   453 GPLISLKCSASGSPP-PQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGL 516
            |..:...|.|:..|| ..:.|.....|::.       |.|..:::..|. |.|    ..|     
Human   241 GEKVIFLCQATAQPPVTGYRWAKGGSPVLG-------ARGPRLEVVADA-SFL----TEP----- 288

  Fly   517 YKCVASNSMGSVQHSARLNV-YGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEK--AHQE 578
            ..|..||::||...|..|:| :||.......|:....|||....|.:.|.|:.::.|.:  ..|.
Human   289 VSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQV 353

  Fly   579 LTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARR----DMQLNVNSPPVIEPF 639
            |           ..|..|.:.:|.| .|.|.|.|  |:.||....|    :.:|.||:|||:...
Human   354 L-----------GSGATLRLPSVGP-EDAGDYVC--RAEAGLSGLRGGAAEARLTVNAPPVVTAL 404

  Fly   640 -KFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYS----------LLV 693
             ..|..|:  |.|::.|.|.:...|....|..|:..:.:..|.....|.|.:          |:.
Human   405 HSAPAFLR--GPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLIS 467

  Fly   694 FKDISARH----SGKYTCYASNAAAKVNYTAELQVR-VAPRWRY-----EPMDTAIMLGNTISIN 748
            ...||...    |..:.|.|.|...:....|.|..| :.|..|.     ....|.:|:...:::.
Human   468 VLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALC 532

  Fly   749 C------EAEGYPIPTITWFKGQGKGS-------------KDFKPLSMRNHSLLL-----NLAT- 788
            |      .|.......:....|...||             :|..|:...:||.|:     .|.| 
Human   533 CWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEEGTLETK 597

  Fly   789 DNDEGYY 795
            |...|||
Human   598 DPTNGYY 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 21/101 (21%)
Ig 264..334 CDD:143165 18/80 (23%)
I-set 345..433 CDD:254352 9/87 (10%)
Ig 358..431 CDD:143165 9/72 (13%)
Ig 456..533 CDD:143165 18/77 (23%)
IGc2 553..619 CDD:197706 18/67 (27%)
I-set 634..724 CDD:254352 23/104 (22%)
ig 645..712 CDD:278476 17/80 (21%)
IG_like 734..815 CDD:214653 18/87 (21%)
Ig 745..815 CDD:299845 16/76 (21%)
I-set 820..913 CDD:254352
Ig 838..920 CDD:299845
FN3 917..1033 CDD:238020
FN3 1040..1142 CDD:238020
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
KIRREL2NP_954649.3 IG_like 30..119 CDD:214653 29/99 (29%)
IGc2 38..106 CDD:197706 21/73 (29%)
I-set 126..224 CDD:254352 29/164 (18%)
Ig2_KIRREL3-like 141..223 CDD:143236 25/146 (17%)
Cell attachment site. /evidence=ECO:0000255 149..151 0/1 (0%)
Ig 231..306 CDD:299845 20/91 (22%)
IG_like 234..308 CDD:214653 21/90 (23%)
Ig 312..395 CDD:299845 24/96 (25%)
I-set 317..395 CDD:254352 23/91 (25%)
Ig 397..501 CDD:299845 23/105 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..601 11/55 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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