DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Neo1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_038938340.1	Gene:	Neo1 / 81735	RGDID:	619837	Length:	1492	Species:	Rattus norvegicus

Alignment Length:	1797	Identity:	368/1797 - (20%)
Similarity:	608/1797 - (33%)	Gaps:	589/1797 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 ADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVN---SGGTANFNCTTTGSAIDA 371
            |.||:||:.:..:|:         |........:.:||.:.::.   ||..|
  Rat     2 AAEREAGRLLSTSSS---------RRCCPPRPLLLLLPLLLLLGRPASGAAA------------- 44

  Fly   372 IDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGD 436
               ..||.|.|:..|      ::|..:....||:.|                            |
  Rat    45 ---AKNGSPPQSAGA------SVRTFTPLYFLVEPV----------------------------D 72

  Fly   437 TVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGD-- 499
            |:          :|| |..:.|.|||...|.|...|..|               |.|:::..|
  Rat    73 TL----------SVR-GSSVILNCSAYSEPSPNIEWKKD---------------GTFLNLVSDDR 111

  Fly   500 ----------VISHLNISHVRPDDGGLYKCVAS-NSMGS-VQHSARLNVYG-PPYVRAIGPIKAV 551
                      :.:.::..|.:||: |.|:|||: :::|: |..:|:|.|.| |.:.....|....
  Rat   112 RQLLPDGSLFISNVVHSKHNKPDE-GFYQCVATVDNLGTIVSRTAKLAVAGLPRFTSQPEPSSIY 175

  Fly   552 AGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNH-YELASVADGGQLVIKNVEPGRDQGIYTCIVR 615
            .|...|::|......|..:|||:..|.|...:. .:|.|    |.|||.|...| |:|:|.|||.
  Rat   176 VGNSGILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPS----GTLVISNATEG-DEGLYRCIVE 235

  Fly   616 SRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQ 680
            |              ..||     ||                                |..:.|:
  Rat   236 S--------------GGPP-----KF--------------------------------SDEAELK 249

  Fly   681 ITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTI 745
            :.::.||...|:                                     :...|.....::|.:.
  Rat   250 VLQESEEMLDLV-------------------------------------FLMRPSSMIKVIGQSA 277

  Fly   746 SINCEAEGYPIPTITWFKGQG--KGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLK 808
            .:.|.|.|.|.|.|.|.|.:.  ......:...:...||.::..|::|.|.|.|.|.|.     .
  Rat   278 VLPCVASGLPAPVIRWMKNEDVLDTESSGRLALLAGGSLEISDVTEDDAGTYFCVADNG-----N 337

  Fly   809 KTI----RINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIA 869
            |||    .:.|..|..|.:...||.:|.:..:..:|...|....|:.|.: ||.:.:.:..|.|.
  Rat   338 KTIEAQAELTVQVPPEFLKQPANIYARESMDIVFECEVTGKPAPTVKWVK-NGDVVIPSDYFKIV 401

  Fly   870 EMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAE---QIIFL----AVQERPDT-------- 919
            :       :..|.:....:.|.|.|:|||||..|.|:   |:|.|    |:...|.|
  Rat   402 K-------EHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHDVAIPTLPPTSLTSATTD 459

  Fly   920 -------------PSHLEIFEVGSRTVKLSWRRP-FDGNSPVLSYLVQYQALKYLQSHGSLAAAG 970
                         |..:....|.:|.:||:||.| .|.:...|:|.|.|             ...
  Rat   460 HLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY-------------TKE 511

  Fly   971 GDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQE 1035
            |.....|.|.|.|.           .....:..|.|||.::.::.|.|:......:..:.::||.
  Rat   512 GVARERVENTSQPG-----------EMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQP 565

  Fly  1036 EAPTEAPS-NVQVQTGGESELIVTWQIPPRESWNGELIGYTV----NCSEEKQNINFISVVNSSL 1095
            |.....|: |::......:.:.|||:.|  .|.|||:..|.:    ..::::|:::.
  Rat   566 EVQLPGPAPNIRAYATSPTSITVTWETP--LSGNGEIQNYKLYYMEKGTDKEQDVDV-------- 620

  Fly  1096 KSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALS 1160
                    ::...|:.||:||:.|:..:.|.|..|.|..:..:...|...||.|||||::....:
  Rat   621 --------SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRN 677

  Fly  1161 SQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRV 1225
            |:|:.|.|..|......|.|.||||.||....:.|...  .:...:.|...:..|.:.:.|:.||
  Rat   678 SKSIVIHWQPPSSATQNGQITGYKIRYRKASRKSDVTE--TVVTGTQLSQLIEGLDRGTEYNFRV 740

  Fly  1226 LAYTATGDGLASHPLFCQT------DDDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYTV 1284
            .|.|..|.|.|:..|..:|      :..||:.|:::....|.. ||::||..|:|:|.::..|.:
  Rat   741 AALTVNGTGPATDWLSAETFESDLDESRVPEVPSSLHVRPLVT-SIVVSWTPPENQNIVVRGYAI 804

  Fly  1285 -YSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTR 1348
             |.     .|......::||......|.|  :|..:..|...:.|..:||||.|   :.::..||
  Rat   805 GYG-----IGSPHAQTIKVDYKQRYYTIE--NLDPSSHYVITLKAFNNVGEGIP---LYESAVTR 859

  Fly  1349 APARIASFGQVVRKAVGTGLVLECLAVGNPTP-----------------RARW----LTRDRPVT 1392
            .....:.....|..|..|       .|.:|||                 |..|    |.:.:.:|
  Rat   860 PHTDTSEVDLFVINAPYT-------PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKIT 917

  Fly  1393 FSPFYEVTNEGNL-----------------------------KIHRVEGSLSGNYTCTANNLFGS 1428
            .|.:|.|..:.|:                             .:...:|..|..::.||:.
  Rat   918 DSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHG---- 978

  Fly  1429 DEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGES----WSITEL 1489
              ..::::...||....::.:.....:|.|:|..|.:....:.||.|.|.|...:    |.|..:
  Rat   979 --ATFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPV 1041

  Fly  1490 LPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWT-KGKAS-QAPNANELIATNATCVN 1552
            :.......|..|.....|..|:.|.|..|.|..||.:...| |..:| :.||            :
  Rat  1042 VGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPN------------D 1094

  Fly  1553 LKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATND 1617
            ..|.|...||                |...:.||                     |:..:|.:|.
  Rat  1095 QALGSAGKGG----------------RLPDLGSD---------------------YKPPMSGSNS 1122

  Fly  1618 AGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIA 1682
            .       |.|.|:            |.:::                   :::|:|:::.:|||.
  Rat  1123 P-------HGSPTS------------PLDSN-------------------MLLVIIVSIGVITIV 1149

  Fly  1683 LTI--------------KHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQQVYSASPVKTVDKGN 1733
            :.:              |.:|..|..:...::.:   |:.|:               ||..|...
  Rat  1150 VVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYK---GNCKD---------------VKPPDLWI 1196

  Fly  1734 ESEMYEISPYATFSVNGGRTGAPAKTPT---RAVAAQTPLDYTMQFKTF-------GHPEGENLN 1788
            ..|..|:.|     ::......|..|.|   |.....||:|.:|.....       ||...::::
  Rat  1197 HHERLELKP-----IDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMS 1256

  Fly  1789 A------------------------TAYPL----LPSSGFGHVKSKSSWHKQRYYNTEDESTLSK 1825
            .                        :|:|:    .|...| |..|.:|..:...|:......:..
  Rat  1257 TLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHF-HSSSLASPARSHLYHPSSPWPIGT 1320

  Fly  1826 SMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDG 1890
            ||::        |.::|...|.::                 :|||:  .||.         ||..
  Rat  1321 SMSL--------SDRANSTESVRN-----------------TPSTD--TMPA---------SSSQ 1349

  Fly  1891 RAVVDMFRPDSSTESN-------NDQGSPAPERRHNTPRHVL 1925
            ....|...|:.:|.|:       .|.|...| ..|..|.|.|
  Rat  1350 TCCTDHQDPEGATSSSYLASSQEEDSGQSLP-TAHVRPSHPL 1390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	7/26 (27%)
		Ig	264..334	CDD:143165	6/23 (26%)
		I-set	345..433	CDD:254352	14/90 (16%)
		Ig	358..431	CDD:143165	10/72 (14%)
		Ig	456..533	CDD:143165	21/90 (23%)
		IGc2	553..619	CDD:197706	24/66 (36%)
		I-set	634..724	CDD:254352	8/89 (9%)
		ig	645..712	CDD:278476	5/66 (8%)
		IG_like	734..815	CDD:214653	22/86 (26%)
		Ig	745..815	CDD:299845	20/75 (27%)
		I-set	820..913	CDD:254352	26/99 (26%)
		Ig	838..920	CDD:299845	25/109 (23%)
		FN3	917..1033	CDD:238020	26/137 (19%)
		FN3	1040..1142	CDD:238020	22/106 (21%)
		fn3	1150..1237	CDD:278470	27/86 (31%)
		FN3	1263..1345	CDD:238020	22/82 (27%)
		Ig	1350..1436	CDD:299845	19/135 (14%)
		IG_like	1358..1436	CDD:214653	19/127 (15%)
		FN3	1441..1530	CDD:238020	22/92 (24%)
		FN3	1542..1620	CDD:238020	10/77 (13%)
Neo1	XP_038938340.1	IgI_1_Neogenin_like	63..159	CDD:409387	31/150 (21%)
		Ig strand B	81..85	CDD:409387	1/3 (33%)
		Ig strand C	94..98	CDD:409387	0/3 (0%)
		Ig strand E	118..122	CDD:409387	0/3 (0%)
		Ig strand F	137..142	CDD:409387	2/4 (50%)
		Ig strand G	152..155	CDD:409387	0/2 (0%)
		Ig	163..250	CDD:416386	32/142 (23%)
		Ig strand C	193..197	CDD:409353	1/3 (33%)
		Ig strand E	215..219	CDD:409353	2/3 (67%)
		Ig strand F	229..234	CDD:409353	2/4 (50%)
		Ig strand G	243..246	CDD:409353	1/2 (50%)
		Ig	263..348	CDD:416386	22/89 (25%)
		Ig strand A	263..266	CDD:409353	0/2 (0%)
		Ig strand A'	268..272	CDD:409353	0/3 (0%)
		Ig strand B	275..284	CDD:409353	1/8 (13%)
		Ig strand C	290..295	CDD:409353	2/4 (50%)
		Ig strand C'	298..304	CDD:409353	0/5 (0%)
		Ig strand D	307..312	CDD:409353	0/4 (0%)
		Ig strand E	313..320	CDD:409353	2/6 (33%)
		Ig strand F	327..335	CDD:409353	4/7 (57%)
		Ig strand G	338..348	CDD:409353	3/9 (33%)
		IgI_4_Neogenin_like	355..438	CDD:409388	23/90 (26%)
		Ig strand B	369..373	CDD:409388	0/3 (0%)
		Ig strand C	382..386	CDD:409388	1/3 (33%)
		Ig strand E	404..408	CDD:409388	1/3 (33%)
		Ig strand F	418..423	CDD:409388	2/4 (50%)
		Ig strand G	431..434	CDD:409388	0/2 (0%)
		FN3	470..563	CDD:238020	24/116 (21%)
		FN3	570..659	CDD:238020	22/106 (21%)
		FN3	667..759	CDD:238020	29/93 (31%)
		FN3	770..849	CDD:214495	22/86 (26%)
		FN3	887..980	CDD:238020	12/98 (12%)
		FN3	987..1082	CDD:238020	23/94 (24%)
		Neogenin_C	1189..1492	CDD:399527	47/245 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910