DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Ceacam5

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_082756.1	Gene:	Ceacam5 / 73250	MGIID:	1920500	Length:	947	Species:	Mus musculus

Alignment Length:	1119	Identity:	221/1119 - (19%)
Similarity:	359/1119 - (32%)	Gaps:	392/1119 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KALLLGALLLAVLATPLLATSGLRVPTFLLEPAPRLLFGNDT------------------GAQVT 59
            :.|||.|..|.....|..|..     |..||| |:::.|.:.                  |.::.
Mouse    16 QGLLLTASFLTCCHLPTTAQI-----TIELEP-PQVIEGENVLIRVNNLTENLITLAWFRGMRIK 74

  Fly    60 CTAHGSPPPLVTWVLRDGSLATQV----PGLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASN 120
            ....|...|           ||:|    ||   .||..||:....|..|..|......|..|..|
Mouse    75 SPQIGQYTP-----------ATKVTVLGPG---HSGRETLYSNGSLQIYNVTQEDIGFYSLRIIN 125

  Fly   121 EAGTVLSRNVQVHAVVRRQFHVHVENTEVYLG-NSALIKCAIP--------EYVRPYVRVAS--- 173
            :           ||.:       |..|.:||. .|:|..|..|        |.|.|.:....
Mouse   126 K-----------HAEI-------VSITSIYLNVYSSLWTCEHPSPHAKLTIESVPPGISEGGSVL 172

  Fly   174 --------------WHRGEEILLPDLSDVA----------------GRYVVLAASGDLYVRSV-R 207
                          |::|  ::.....::|                ||..|. ::|.|.::.| :
Mouse   173 LLVKNLPQNLLSLFWYKG--VIAVKKFEIARHIKATNSSVPGPAHTGRETVF-SNGSLLLQEVMQ 234

  Fly   208 SEDGLMKFSCLVTNTLNGERQRSDAVM----------LQVK--ELSKNLAPRTTQKPVMEIHVER 260
            |:.|......:.|: |..|.......|          ||||  .|.:|:|...|  .::.:|
Mouse   235 SDTGFYTLRTMSTD-LKDEVAHVQLYMDTYLLTCYHPLQVKIESLPQNVAVGKT--VLLLVH--- 293

  Fly   261 GNDVHLPCNIQGNPFPIFTWY---------------RVSDSAALYPIPSSQRVILSRTLLLIKNA 310
                :||     ..|..|.||               |..|:..|....||:..|.:...:||.:.
Mouse   294 ----NLP-----EDFQAFFWYKSAYRRDTYKIAEYKRAMDATILGSAYSSREFIYNNGSMLIIDV 349

  Fly   311 DERDAGKWICQASNQFGEQRIE---IRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAI 372
            .|.|||.::.:...:  :.:||   |:|.|||:||       ...:|..||..:..:...:|
Mouse   350 TEDDAGYFLLEILRE--DLKIEKAYIQLHVNSFVS-------NSKDSASTARLSIESVPPSI--- 402

  Fly   373 DWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDT 437
              :..|..|                    |||.|:.:..:.::.         .:.|...|..:.
Mouse   403 --VEGGSVL--------------------LLVHNLPKNLQSLFW---------YKGMIAEKKSEL 436

  Fly   438 VPELIYTFIEQNVRPGPLISLKCSA--SGSPPPQFAWLLDSQ----PIMDVSLHHRFAIGQFVDM 496
            :..:|.|   .:..|||..|.:.:.  :||...|.....|:|    ..||..|.:.
Mouse   437 IQHIIAT---SSSLPGPAHSGRETVYNNGSLLLQRVMQNDTQFYTLQTMDTDLKYE--------- 489

  Fly   497 SGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCP 561
                ::|:.:.             ...|:.:..|..::.:...|...|:|  |:|.   .:||
Mouse   490 ----VAHVQLQ-------------LDTSLSTWYHPLQVKIESLPRNVAVG--KSVL---FLVH-- 530

  Fly   562 FAGYPVEQIR---WEKAHQELTTSNHYELASVAD----------------GGQLVIKNVEPGRDQ 607
              .:| |..|   |.|...:..||...|.....|                .|.:|:.:|... |.
Mouse   531 --NFP-EVFRAFSWYKPAYKSHTSKIVEYHRFTDSATVGAAYRGIEVIFTNGSMVMIDVTED-DA 591

  Fly   608 GIYTCIVRSRAGEEARRDMQLNVNS-------------------PP--------VIEPFKFPKNL 645
            |.|...:.....:..:..:||:|||                   ||        ::.....||||
Mouse   592 GFYMLEILREDFKVEKAYVQLHVNSFVPNSKVSVSTARLSIESVPPSIVGGESVLLLVHNLPKNL 656

  Fly   646 QEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDIS---ARHSGKYTC 707
            |.                  ..|.|.        .|.|:|.|....::....|   ..|||:.|.
Mouse   657 QS------------------LFWYKG--------VIAEEKSELIQHIIATSSSLPGPAHSGRETV 695

  Fly   708 YASNAAAKVN---------YT------------AELQVRV----------APRWRYEPMDTAIML 741
            | ||.:..:.         ||            |.:|:::          :.:....|:...|.:
Mouse   696 Y-SNGSLLLQRVMQNDTGFYTLLTMSTDLKDEIAHVQLQLDTSTCCSLLTSDQLIIVPVPRNIAV 759

  Fly   742 GNTISINCEAEGYPIPTITWFK----------------------GQGKGSKDFKPLSMRNHSLLL 784
            |.::.:........:.||.|:|                      |.....|:   :...|.|||:
Mouse   760 GKSVLLLVCNVPKDVQTIFWYKSVYRTDIFKIAEYSRSMESTIWGLAHSGKE---MVYTNGSLLI 821

  Fly   785 NLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFE-QSARNISSRRNDPVTLDCHAKGDEPI 848
            ...|::|.|.||.:..::.....:..::::||.|..:. ....:.:.|....|...|.: .|..:
Mouse   822 QNVTEHDAGLYMLEILHKDYKLERAHVQVHVNNPVSWPFVRVTDTTVRVQSSVVFTCFS-ADPGV 885

  Fly   849 TIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAV 913
            :|.|..|...:.|.. |.:::..|      .||:|....|.|:|.|:|...||           |
Mouse   886 SIRWLFNKQSLQLTE-RMTLSPSK------CQLSIDPVWREDAGKYQCEVSNP-----------V 932

  Fly   914 QERPDTPSHLEIFE 927
            ..:...|..|.:.|
Mouse   933 SSKSSLPVRLAVIE 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	17/80 (21%)
		Ig	56..125	CDD:143165	17/72 (24%)
		I-set	246..337	CDD:254352	24/108 (22%)
		Ig	264..334	CDD:143165	20/87 (23%)
		I-set	345..433	CDD:254352	11/87 (13%)
		Ig	358..431	CDD:143165	9/72 (13%)
		Ig	456..533	CDD:143165	12/82 (15%)
		IGc2	553..619	CDD:197706	17/84 (20%)
		I-set	634..724	CDD:254352	23/121 (19%)
		ig	645..712	CDD:278476	15/69 (22%)
		IG_like	734..815	CDD:214653	18/102 (18%)
		Ig	745..815	CDD:299845	15/91 (16%)
		I-set	820..913	CDD:254352	20/93 (22%)
		Ig	838..920	CDD:299845	19/81 (23%)
		FN3	917..1033	CDD:238020	3/11 (27%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Ceacam5	NP_082756.1	Ig_CEACAM_D1	36..134	CDD:143251	27/135 (20%)
		Ig_CEACAM_D1	156..258	CDD:143251	17/105 (16%)
		Ig_CEACAM_D1	273..377	CDD:143251	29/119 (24%)
		Ig_CEACAM_D1	393..496	CDD:143251	24/152 (16%)
		Ig	510..614	CDD:299845	24/114 (21%)
		Ig_CEACAM_D1	630..733	CDD:143251	25/129 (19%)
		Ig_CEACAM_D1	748..852	CDD:143251	18/106 (17%)
		IG_like	865..944	CDD:214653	23/97 (24%)
		IGc2	872..933	CDD:197706	19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000