back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and TTN

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001254479.2	Gene:	TTN / 7273	HGNCID:	12403	Length:	35991	Species:	Homo sapiens

Alignment Length:	2030	Identity:	430/2030 - (21%)
Similarity:	716/2030 - (35%)	Gaps:	485/2030 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FLLEPAPRLLFGNDTGAQ------VTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFP 98
            |:.|||..|...:|...:      :..|..|:.|..||| .:||...|.......::...|.
Human  7225 FVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTW-KKDGFNITTSEKCNIVTTEKTC--- 7285

  Fly    99 PFLAQYYRTDVHEATYRCRASNEAGTVLSRNV---QVHAVVRRQFHVHVENTEVYLGNSALIKCA 160
             .|.....|......|.|...||||    |:|   .|..:....|...:|..|..:|:|..::|.
Human  7286 -ILEILNSTKRDAGQYSCEIENEAG----RDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQ 7345

  Fly   161 I---PEYVRPYVRVASWHRGEEILLP----------DLSDVAGRYVVLAASGDLYVRSVRSEDGL 212
            :   ||.      ..||::|:..|.|          :::.:....|.:..||:
Human  7346 VAGTPEI------TVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGE------------ 7392

  Fly   213 MKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPI 277
              ::|...|:: |.........:|.::|     |.:..:.:.:|....|..|.|.|.:.|:. ||
Human  7393 --YTCKAENSI-GTASSKTVFRIQERQL-----PPSFARQLKDIEQTVGLPVTLTCRLNGSA-PI 7448

  Fly   278 -FTWYRVSDSAALYPIPSSQRVILSRTLLL-IKNADERDAGKWICQASNQFGEQRIEIRLSVN-- 338
             ..|||  |...|....:.|...:.....| |...|...:|::.|.|||..|......||:..
Human  7449 QVCWYR--DGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREP 7511

  Fly   339 --------SYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQ--ANNALTT--GR 391
                    ..||:.::       :|.:|:|.|..||:....|.|..:.|.::  .|..:|.  ..
Human  7512 KKSPFFDIKPVSIDVI-------AGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNT 7569

  Fly   392 DNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNV-RPGPL 455
            .::|.|        .||:.|.|.|.|...|........|:|.:.:. |:.:.......| :.|..
Human  7570 PHLRIL--------KVGKGDSGQYTCQATNDVGKDMCSAQLSVKEP-PKFVKKLEASKVAKQGES 7625

  Fly   456 ISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIG-QFVDMSGDVISHLNISHVRPDDGGLYKC 519
            |.|:|..||||..:.:|..:     |..||..:... .|::.    ::.|.|:....:|.|.|.|
Human  7626 IQLECKISGSPEIKVSWFRN-----DSELHESWKYNMSFINS----VALLTINEASAEDSGDYIC 7681

  Fly   520 VASNSMGSVQHSARLNVYGPP-YVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSN 583
            .|.|.:|....|..|.|..|| :.:...|:.|:.|.|:|:.|..:|.|..::.|.|..:::..|.
Human  7682 EAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSK 7746

  Fly   584 HYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEG 648
            .:::.|......|.|.|:| ..|.|.|.|...:..|.:. ....:....||     :|.|.|.:.
Human  7747 KFKITSKHFDTSLHILNLE-ASDVGEYHCKATNEVGSDT-CSCSVKFKEPP-----RFVKKLSDT 7804

  Fly   649 ----GRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSL------LVFKDISARHSG 703
                |.|....|:..|..||...|.||...:     |.|.:....|.      |......|.:||
Human  7805 STLIGDAVELRAIVEGFQPISVVWLKDRGEV-----IRESENTRISFIDNIATLQLGSPEASNSG 7864

  Fly   704 KYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKG 768
            ||.|...|.|.....:|.|.|....|...:|....:..||..::.|...|.|..:..|||...:.
Human  7865 KYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGREL 7929

  Fly   769 SKDFKPLSMRNH--------SLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNE---PARFE 822
            |.|.|     :|        ||.:..|..:|:|.|..:..|.:|.. ..|:.::|::   |..|.
Human  7930 SADSK-----HHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKS-NCTVSVHVSDRIVPPSFI 7988

  Fly   823 QSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQ---LTIG 884
            :..:::::.....|.|:|...|..||::||.|:...|        ::..|.:......   |.:.
Human  7989 RKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEI--------VSGPKCQSSFSENVCTLNLS 8045

  Fly   885 HSDRHDSGVYRCIAENPYGRAEQIIFLAVQERP---DTPSHLEIFE----------VGSRTVKLS 936
            ..:..|:|:|.|:|.|..|..|....|.|||.|   .||..:|:..          .|:...|:.
Human  8046 LLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVK 8110

  Fly   937 W----RRPFDGNSPVLSY--------LVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISR 989
            |    |....|.|..:|.        |.:.|.|:           .||::..|.|
Human  8111 WFKGSRELVPGESCNISLEDFVTELELFEVQPLE-----------SGDYSCLVTN---------- 8154

  Fly   990 SYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESE 1054
                       .||....||.|...:....::|.|                   :..|:||....
Human  8155 -----------DAGSASCTTHLFVKEPATFVKRLA-------------------DFSVETGSPIV 8189

  Fly  1055 LIVTWQ-IPP-RESW--NGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRK 1115
            |..|:. .|| ..||  :..||..:..||           :..:.||||:....:|      :..
Human  8190 LEATYTGTPPISVSWIKDEYLISQSERCS-----------ITMTEKSTILEILEST------IED 8237

  Fly  1116 YSRYAVTIRAMNSFGSGPWSAAI-------FGTTAEGVPEAA---PQNVNCTALSSQSLKISWLE 1170
            |::|:..|.  |..|.....|.:       |....|.| ||.   |..:.|....:..::|||.:
Human  8238 YAQYSCLIE--NEAGQDICEALVSVLEPPYFIEPLEHV-EAVIGEPATLQCKVDGTPEIRISWYK 8299

  Fly  1171 PPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGL 1235
            ...:....  ..||:.::..|      |.|.|.:..:.:...::. ||.| |:..:|.:|.....
Human  8300 EHTKLRSA--PAYKMQFKNNV------ASLVINKVDHSDVGEYSC-KADN-SVGAVASSAVLVIK 8354

  Fly  1236 ASH--PLFCQTDDDVPDA---PAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQA 1295
            |..  |.|.:...||.:.   |.|.:.....::.:.:||.    ::|::      .::......:
Human  8355 ARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWY----KDGVL------LKDDANLQTS 8409

  Fly  1296 KTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQV- 1359
            ..|.|        .|.:.....::.:.::..|||..:|....::.:..:.:...|     |..:
Human  8410 FVHNV--------ATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPP-----FFDLK 8461

  Fly  1360 ---VRKAVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVT---NEGNLKIHRVEGSLSGNY 1418
               |..|:|.....:|...|....:..|...:|.:.....|::|   |...|.:.:|....:|.|
Human  8462 PVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQY 8526

  Fly  1419 TCTANNLFGSDEIQYQVIAMKPPS-----APQIIV----------QYASADSIRVSWDAPD---- 1464
            ||.|:|:.|.|....|:...:||.     .|..||          :...:..|:|.|...:
Human  8527 TCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQ 8591

  Fly  1465 ----------DGGAPLQGYTISYHTAGESWSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGS 1519
                      |..|.|:.:.:|...:|:             :|     |        .|||..||
Human  8592 ESSKFRMSFVDSVAVLEMHNLSVEDSGD-------------YT-----C--------EAHNAAGS 8630

  Fly  1520 GVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCSIH-HFSIEHRPLGDIRWTVV 1583
            ..:|..:.|.......:.|:..|.:.                |..:| ...::..|...:.|...
Human  8631 ASSSTSLKVKEPPIFRKKPHPIETLK----------------GADVHLECELQGTPPFHVSWYKD 8679

  Fly  1584 TSDISNAEENR---EN------LIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITI-P 1638
            ..::.:.::.:   ||      ::..|......||.:  ||||.|        |.|.:..|.: .
Human  8680 KRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCK--ATNDVG--------SDTCVGSIALKA 8734

  Fly  1639 PPSVFPSENDL---------MNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCGP 1694
            ||......:|:         :...|....|.|..||                    |.:    |.
Human  8735 PPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWF--------------------KDK----GE 8775

  Fly  1695 IAEGYESRTLPGDYKEDHENRRNQQVYSASPVK-TVDKGNESEMYEISPYATFSVNGGRTGAPAK 1758
            |..  ||..:...|.|:....:..:|..|:..| |....|::.|.|.  :||.||....|.....
Human  8776 IVR--ESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQEC--FATLSVLEPATIVEKP 8836

  Fly  1759 TPTRAVAAQTPLDYTMQFKTFGHPEGENLNATAYPLLPSSGFGHVKSKSSWHKQR--YYNTEDES 1821
            ...:.....|   .|::....|.||           |.:..|...|..:|.:|.:  ::|
Human  8837 ESIKVTTGDT---CTLECTVAGTPE-----------LSTKWFKDGKELTSDNKYKISFFN----- 8882

  Fly  1822 TLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVA-------GSESDTSISPSTEFSNMPTYR 1879
                              |.:|.:....:.:.|||.:       |.:|.|:....::.:..|::.
Human  8883 ------------------KVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFT 8929

  Fly  1880 VPCKSSRSSDGRAVV 1894
            ...|.:....|.:||
Human  8930 RKLKETNGLSGSSVV 8944

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.