DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and CNTN2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_024305154.1 Gene:CNTN2 / 6900 HGNCID:2172 Length:1200 Species:Homo sapiens


Alignment Length:1574 Identity:340/1574 - (21%)
Similarity:502/1574 - (31%) Gaps:539/1574 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 ALLLAVLATPLLATSGLRV-----PTFLLEPAPRLLFGNDTGAQV--TCTAHGSPPPLVTWVLRD 76
            ||...|:::|...:|.|..     |.|..:|...|.....|..||  .|.|..|||....|.: :
Human    26 ALRHLVVSSPAAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKM-N 89

  Fly    77 GSLATQVPGLRK--ISGNGTLHFPPFLAQYYRTDVHEA-TYRCRASNEAGTVLSRNVQVHAVVRR 138
            |:.....||.|.  :.||..:..|        |...:| .|:|.|||..|||:||    .|::|.
Human    90 GTEMKLEPGSRHQLVGGNLVIMNP--------TKAQDAGVYQCLASNPVGTVVSR----EAILRF 142

  Fly   139 QFHVHVENTE-----VYLGNSALIKCAIPEYVRPYVRVA-SWHRGEEILLPDLSDVAGRYVVLAA 197
            .|.......|     .:.|...::.|..|.:   |..:: .|...|   .|:.....||:.|...
Human   143 GFLQEFSKEERDPVKAHEGWGVMLPCNPPAH---YPGLSYRWLLNE---FPNFIPTDGRHFVSQT 201

  Fly   198 SGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVK---ELSKNLAPRTTQKPVMEIHVE 259
            :|:||:....:.| |..:|||.|:.::...:...:...|:.   |.::..||....:...|.:..
Human   202 TGNLYIARTNASD-LGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYAL 265

  Fly   260 RGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASN 324
            .|..|.|.|...|||.|...|.:|..|.       |.:...:...|.|.:....|.|.:.|:|.|
Human   266 VGQQVTLECFAFGNPVPRIKWRKVDGSL-------SPQWTTAEPTLQIPSVSFEDEGTYECEAEN 323

  Fly   325 QFGEQRIEIRLSVNSYVSVHILPQ-VQIVNS-----GGTANFNCTTTGSAIDAIDWLHNGKPLQA 383
            ..|...::.|:.|.:.      |: :::::.     |....:.|...|.....:.||.||:||.:
Human   324 SKGRDTVQGRIIVQAQ------PEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLAS 382

  Fly   384 NNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQ 448
            .|.:.....::|| ||.||       .|.|:|||:.||:..:..|.|||.:....|:.       
Human   383 QNRVEVLAGDLRF-SKLSL-------EDSGMYQCVAENKHGTIYASAELAVQALAPDF------- 432

  Fly   449 NVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDD 513
                                                                             
Human   433 ----------------------------------------------------------------- 432

  Fly   514 GGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQE 578
                               |||.     ||.:  |.|..|.:|::.|.....|...:.|.|..:.
Human   433 -------------------RLNP-----VRRL--IPAARGGEILIPCQPRAAPKAVVLWSKGTEI 471

  Fly   579 LTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPK 643
            |..|:.   .:|...|.|:|:|:              ||:.|                       
Human   472 LVNSSR---VTVTPDGTLIIRNI--------------SRSDE----------------------- 496

  Fly   644 NLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCY 708
                                                                       |||||:
Human   497 -----------------------------------------------------------GKYTCF 502

  Fly   709 ASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIP--TITWFKGQGKGSKD 771
            |.|...|.|.|..|.||.|.:....|....|.||:.:::.|.|...|..  |.||       :.|
Human   503 AENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTW-------TLD 560

  Fly   772 FKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPV 836
            ..|:..           |...|:|.               |.||.|                   
Human   561 DFPIDF-----------DKPGGHYR---------------RTNVKE------------------- 580

  Fly   837 TLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENP 901
                        |||                            .|||.::.....|.|.|:|:..
Human   581 ------------TIG----------------------------DLTILNAQLRHGGKYTCMAQTV 605

  Fly   902 YGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSL 966
            ...|.:...:.|:..|..|..:.:.::|..|::|||.|.||.:||:..|.:|           :.
Human   606 VDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQ-----------AR 659

  Fly   967 AAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEI---ERSAYTEA 1028
            ....|.|.    .|.....:|..:     .|:|.|.||||...:..|:.|.|.:   |.|..:..
Human   660 TPPAGKWK----QVRTNPANIEGN-----AETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSK 715

  Fly  1029 IVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNS 1093
            |  :|:|.||:.|||.:....|...||||.|....||..||:..||.:                 
Human   716 I--RTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLL----------------- 761

  Fly  1094 SLKSTIVSGWATTKA----------TLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPE 1148
            |.:....:.|.|.:.          :...:|.|:.:.|.||:.|..|.||.|......:||..|.
Human   762 SFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPR 826

  Fly  1149 AAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLH 1213
            .||..|....:||..:.::| ||..|...||:.||:|.|....   |..|..:..||:.|:|...
Human   827 VAPTKVWAKGVSSSEMNVTW-EPVQQDMNGILLGYEIRYWKAG---DKEAAADRVRTAGLDTSAR 887

  Fly  1214 T--LHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISW------- 1269
            .  ||..:.|.:.|.||...|.|.||......|....|..|....:...::.|:.|.|       
Human   888 VSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFR 952

  Fly  1270 -----------------LTP----KNRNGI-------ISHYTVYSREAGRKGQ---AKTHMVRVD 1303
                             |||    ..:|.|       |.|..|..|..|..|.   |:.|:||..
Human   953 NESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNG 1017

  Fly  1304 ENGYPVTFESRSLAENQMY---EFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVG 1365
            ....|:....|.:.:...|   .|         ...||.:..:....:|               |
Human  1018 GAAPPLPLSPREIQDPPRYLRGSF---------PPRPTPISTRKGKWKA---------------G 1058

  Fly  1366 TGLVLECLAVGNP---------TPRARWLTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCT 1421
            ...|...|...:|         :||||                  ||    .||:|. :.:....
Human  1059 RNQVQSSLRTASPPPFYPAPRTSPRAR------------------EG----RRVQGE-AEDQPAI 1100

  Fly  1422 ANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGESWSI 1486
            ||.|    :....|...:|||.|...:|.|                       :..|..||..|.
Human  1101 ANGL----QSTVGVGLRRPPSRPLPGLQLA-----------------------LHKHDGGEHGSP 1138

  Fly  1487 TELLPENNAFTISG 1500
            ....|.:..|.:.|
Human  1139 PSTTPWHRHFPLRG 1152

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 27/81 (33%)
Ig 56..125 CDD:143165 23/73 (32%)
I-set 246..337 CDD:254352 23/90 (26%)
Ig 264..334 CDD:143165 19/69 (28%)
I-set 345..433 CDD:254352 27/93 (29%)
Ig 358..431 CDD:143165 23/72 (32%)
Ig 456..533 CDD:143165 0/76 (0%)
IGc2 553..619 CDD:197706 15/65 (23%)
I-set 634..724 CDD:254352 11/89 (12%)
ig 645..712 CDD:278476 6/66 (9%)
IG_like 734..815 CDD:214653 16/82 (20%)
Ig 745..815 CDD:299845 12/71 (17%)
I-set 820..913 CDD:254352 11/92 (12%)
Ig 838..920 CDD:299845 13/81 (16%)
FN3 917..1033 CDD:238020 31/118 (26%)
FN3 1040..1142 CDD:238020 28/111 (25%)
fn3 1150..1237 CDD:278470 29/88 (33%)
FN3 1263..1345 CDD:238020 24/122 (20%)
Ig 1350..1436 CDD:299845 16/94 (17%)
IG_like 1358..1436 CDD:214653 16/86 (19%)
FN3 1441..1530 CDD:238020 12/60 (20%)
FN3 1542..1620 CDD:238020
CNTN2XP_024305154.1 Ig 49..142 CDD:325142 33/105 (31%)
Ig2_Contactin-2-like 144..241 CDD:143204 22/103 (21%)
Ig 252..337 CDD:325142 23/91 (25%)
Ig4_Contactin-2-like 341..425 CDD:143205 27/91 (30%)
Ig5_Contactin 446..518 CDD:319278 27/170 (16%)
Ig6_Contactin-2 537..616 CDD:143262 26/170 (15%)
FN3 631..718 CDD:238020 29/108 (27%)
FN3 739..813 CDD:238020 23/90 (26%)
FN3 828..920 CDD:238020 31/95 (33%)
Atrophin-1 <1002..1197 CDD:331285 42/225 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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