DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and CEACAM1

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001703.2 Gene:CEACAM1 / 634 HGNCID:1814 Length:526 Species:Homo sapiens


Alignment Length:444 Identity:97/444 - (21%)
Similarity:157/444 - (35%) Gaps:117/444 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 PRTTQKPV--MEIHVERGNDV-----HLPCNIQGNPFPIFTWY---RV------------SDSAA 288
            |.|.|...  |..:|..|.:|     :||..:.|     ::||   ||            :..|.
Human    31 PTTAQLTTESMPFNVAEGKEVLLLVHNLPQQLFG-----YSWYKGERVDGNRQIVGYAIGTQQAT 90

  Fly   289 LYPIPSSQRVILSRTLLLIKNADERDAGKWICQ----------ASNQFGEQRIEIRLSVNSYVSV 343
            ..|..|.:..|.....|||:|..:.|.|.:..|          |:.||                 
Human    91 PGPANSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQF----------------- 138

  Fly   344 HILPQVQIVN-SGGTAN---------FNCTTTGSAIDAIDWLHN-GKPLQANNALTTGRDNIRFL 397
            |:.|::...: |...:|         |.|.........:.|::| ..|:.....|:.|...:..|
Human   139 HVYPELPKPSISSNNSNPVEDKDAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLL 203

  Fly   398 SKSSLLVQNVGRRDRGVYQCLVEN---QRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLK 459
            |        |.|.|.|.|:|.::|   ...|......:..|...|.:..:  :...|||..:||.
Human   204 S--------VTRNDTGPYECEIQNPVSANRSDPVTLNVTYGPDTPTISPS--DTYYRPGANLSLS 258

  Fly   460 CSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNS 524
            |.|:.:||.|::||::               |.|...:    ..|.|.::..::.|.|.|.|:||
Human   259 CYAASNPPAQYSWLIN---------------GTFQQST----QELFIPNITVNNSGSYTCHANNS 304

  Fly   525 MGSVQHSARLNVYGPPYVRAIGPIKA----------VAG--EDIIVHCPFAGYPVEQIRWEKAHQ 577
            :.....:....:    .|..:.|:.|          |.|  :.:.:.|......: .|||...:|
Human   305 VTGCNRTTVKTI----IVTELSPVVAKPQIKASKTTVTGDKDSVNLTCSTNDTGI-SIRWFFKNQ 364

  Fly   578 ELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVN 631
            .|.:|...:|   :.|...:..|.....|.|.|.|.|.:...:.....:.||||
Human   365 SLPSSERMKL---SQGNTTLSINPVKREDAGTYWCEVFNPISKNQSDPIMLNVN 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 28/122 (23%)
Ig 264..334 CDD:143165 22/99 (22%)
I-set 345..433 CDD:254352 20/101 (20%)
Ig 358..431 CDD:143165 18/85 (21%)
Ig 456..533 CDD:143165 19/76 (25%)
IGc2 553..619 CDD:197706 16/67 (24%)
I-set 634..724 CDD:254352
ig 645..712 CDD:278476
IG_like 734..815 CDD:214653
Ig 745..815 CDD:299845
I-set 820..913 CDD:254352
Ig 838..920 CDD:299845
FN3 917..1033 CDD:238020
FN3 1040..1142 CDD:238020
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
CEACAM1NP_001703.2 Ig_CEACAM_D1 36..140 CDD:143251 25/125 (20%)
Required for homophilic binding. /evidence=ECO:0000250|UniProtKB:P16573 39..142 26/124 (21%)
Ig_CEACAM_D4 146..233 CDD:143217 19/94 (20%)
IG_like 157..233 CDD:214653 17/83 (20%)
Ig_2 240..318 CDD:290606 23/102 (23%)
IG_like 244..304 CDD:214653 20/80 (25%)
I-set 317..408 CDD:254352 20/94 (21%)
Ig 340..415 CDD:299845 17/78 (22%)
DUF4690 <419..451 CDD:292384
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:P16573 450..462
Interaction with FLNA. /evidence=ECO:0000250|UniProtKB:P16573 452..526
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..513
Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level. /evidence=ECO:0000250|UniProtKB:P31809 489..526
Essential for interaction with PTPN11 and PTPN6. /evidence=ECO:0000250|UniProtKB:P31809 520..523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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