DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and obsl1b

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_021334748.1	Gene:	obsl1b / 606585	ZFINID:	ZDB-GENE-050809-29	Length:	2929	Species:	Danio rerio

Alignment Length:	1995	Identity:	389/1995 - (19%)
Similarity:	624/1995 - (31%)	Gaps:	649/1995 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 VYLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGDLY---VRSVRSED 210
            |..|..|::||.|....||.|   .|.|..|.:.|:     |||.|. ..|::|   :.||..||
Zfish    19 VQSGTDAVLKCQIGGDPRPAV---IWERNNEKIHPE-----GRYRVF-EDGNVYNLIITSVTMED 74

  Fly   211 GLMKFSCLVTNTLNGE-------RQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPC 268
            . .::.|...|.: ||       :...:|..::|:|.:|   ||...|| :...|.||.|....|
Zfish    75 S-GQYICKAKNCI-GETYAAATLKVEGEAQEMEVREENK---PRFLIKP-LSTRVGRGEDAMFSC 133

  Fly   269 NIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRT-----LLLIKNADERDAGKWICQASNQFGE 328
            .:.|||.|...|.:  |...|..|..|....:|..     .|.|......|.|.:.|:|.|:|||
Zfish   134 KLWGNPRPEVMWEK--DGKKLNEIFESTHFSISYQDGGWFQLKIFKTRAPDGGVYTCKARNEFGE 196

  Fly   329 QRIEIRLSV------------NSYVSVH---------------------ILP-----QVQIVNSG 355
            ......|.|            |.|.:.|                     .||     ::..|..|
Zfish   197 SLAGAVLLVDAGPGHEDEGNRNGYTNGHWKAHQGKQRSGRQVATRLKDDPLPNSAKVKMFAVTEG 261

  Fly   356 GTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKS---SLLVQNVGRRDRGVYQC 417
            ..|.|.|..||.....|.|..:||      .:.:||..:.:..:.   :|.|....::|.|||.|
Zfish   262 KHAKFRCYVTGKPKPEILWRKDGK------LILSGRRYLLYEDREGYFTLKVLYCKQQDNGVYVC 320

  Fly   418 LVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDV 482
            ...|......:...|.:.:..........:..|....|..|:|.......| ..|.|:.:.:...
Zfish   321 SASNTAGQTLSAVHLIVKEPPVRFKQPLNDLQVWERDLAVLECEVPEDSVP-ITWYLEDRRLQPG 384

  Fly   483 SLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGP 547
            :   ::.:.::     .....|.|..:..||.|:|.|..::...|:   |.:.|.|....:....
Zfish   385 A---KYGMEEW-----GTKRRLTIRDIGVDDDGIYLCEMADGGRSI---AEVAVKGTIVRKLPRK 438

  Fly   548 IKAVAGED--------------------------------------IIV---------------- 558
            :..:.||:                                      |:|
Zfish   439 VDVLEGENAAFCVEVEEEEMDIHWYKDGTELRETHQTILKSFGRTHILVFVNTTPQDSGLVMFYV 503

  Fly   559 ---------------HCP---------------------F----------AGYPVEQIRWEKAHQ 577
                           |||                     |          :||.:|  |.|...|
Zfish   504 GRSKTSSQLRVKAARHCPPSCPIGVQINTERANAALLSWFPAQDSRKNPPSGYIIE--RQEVGSQ 566

  Fly   578 E----LTTSN-----------------HYELASVADGGQLVIKNVE---------------PGRD 606
            |    |||.:                 .:.:.||...|:  ..|||               |.:|
Zfish   567 EWLQCLTTDSATSVEILGDSVPCEADYRFRICSVNKYGR--SGNVEFPRAVHLVPVARIQAPLQD 629

  Fly   607 ----QGIYTC---------------------------IVRSRAGEEAR----RDMQ--------- 627
                :|...|                           |.|||..:..|    ||..
Zfish   630 ALVPEGQDACFTIELSASVIGTWFLNGNQLQDDERFSIRRSRTHQSLRIRGVRDTDNGAEITFIA 694

  Fly   628 --------LNVNSPPVIEPFKFP--------KNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIP 676
                    |.:.:|.|    ||.        |.::.|....:.|.:|..:.|:  .|.|:...:.
Zfish   695 YGIRDSAALYIQAPLV----KFTPLSEMDRNKFVEVGNPIVLYCELSDPEAPV--RWYKNGVELQ 753

  Fly   677 SSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPM-----D 736
            |...:..:.|.....:|.:.....|||.|:|.|.:...:.|...|     ||..|:..:     :
Zfish   754 SMEGLHIQSEGTMRRIVIQSAEFSHSGVYSCDAIDDVIRFNVEVE-----APPVRFSVVPEGKRN 813

  Fly   737 TAIMLGNTISINCEAEGYPIPTITWFKGQGK----GSKDFKPLSMRNHSLLLNLATDNDEGYYMC 797
            .:|.:|.||::.||... |:..::|:|...|    ...|||.:..: ..|::..|.....|.|.|
Zfish   814 KSIEVGTTIALQCELSD-PVAQVSWYKDGVKLLPQSGVDFKSVGTK-RELVVQSAEFYHSGVYSC 876

  Fly   798 QATNEIGAGLKKTIRINVN---EPARFEQSARNISSRR----NDPVTLDCHAKGDEPITIGWTQN 855
            :...:       .:..:|:   .|.|| .:...:..|:    ..|:||.|.. .|....:.|.::
Zfish   877 KTRGD-------AVHFSVDVKAPPVRF-SAVPEVKRRKCIEAGCPITLQCEI-SDSAAQVQWYKD 932

  Fly   856 NGRIDLNNFRFSIAEMKTEKGV-----DSQLTIGHSDRHDS--GVYRCIAENPY------GRAEQ 907
            ...:              |.||     |...|:.....|.|  |||.|..::..      .||..
Zfish   933 GNLV--------------ESGVDINSDDCMRTLSIQSAHPSHAGVYSCTTKDDVLEFHVEIRAAP 983

  Fly   908 IIFLAVQER-----PDTPSHLEI-FEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSL 966
            :.|.||.|.     .:...|.|: .:|....|.:||   |..::.     :|.:....:||.|..
Zfish   984 VRFSAVPEAGKNICTEAGGHFELCCKVSDPAVHVSW---FHNDTQ-----LQPETGLDVQSEGEA 1040

  Fly   967 AAAGGDWNGHVINVSLPSTS----ISRSYDS-----DLRESAIVAGLTPATTFLIRMQAIN---- 1018
            ...       ::|.:.|..|    ...|.||     |:::..::....|.|.....::|.|
Zfish  1041 RTL-------IVNPAEPRHSGLYRCETSDDSVQFTVDIKDPPVMFSALPDTVKNRLIEADNSTDL 1098

  Fly  1019 --EIER-----SAYTEAI--VLKTQEEAPTEA-----------PSNV----QVQTGGESELIVTW 1059
              ||..     ..|.:.:  |.|:|....:|.           ||..    .|:||...:..|..
Zfish  1099 YGEISEPNAKVCCYKDGVELVSKSQPHIKSECTRRTLAVKTAQPSKSGWYDYVRTGDVFQFNVQD 1163

  Fly  1060 QIPPRESWNGELIGYTVNCSEEKQNINFISVVNS-------SLKSTIVSGWATTKATLRGLRKYS 1117
            |:.|           |:....|.|...|:..:.|       |..:..||.....|..|    ..|
Zfish  1164 QVSP-----------TILADPEVQKTKFVEEMESVVLPYEISDPAPYVSQTKEEKVML----PQS 1213

  Fly  1118 RYAVTIRAMNSFGSGPWSA------AIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQF- 1175
            :....:.:.:.|  .|.|.      |..|......||.:...|.|....         |.|:||
Zfish  1214 KPEPELESNSDF--DPESKHEVHLDASRGALIIHSPETSLVKVKCPKTP---------EDPIQFE 1267

  Fly  1176 -------HGGIIQGYKILYRPIVH--------QIDFPAKLEIKRTSNLET--------------- 1210
                   |..:..|.  :|...|.        .:.|....|::|...:|:
Zfish  1268 MDQAELSHYEVFSGE--IYDDSVQCTLDTKAPPVMFSTIDEVQRNKCIESGRPFKLQCEVSDPDA 1330

  Fly  1211 ----YL---HTLHK-----ASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTAD 1263
                |.   ..|.:     .|...||.|:..| .:...|....||.:||.......|||.:|  .
Zfish  1331 QVWWYKDGNEVLPQDGIVIGSEEGIRTLSVQA-AELCHSGTYRCQMNDDAITFHVEIKAPSL--K 1392

  Fly  1264 SILISWLTPKNRNGIISHYTVYSREA------------GRKGQAKTHM-VRVDENGYPVTFESRS 1315
            .|.||.: .||::..:....|...|.            ||:......: .:.|||...:..||..
Zfish  1393 FIPISEV-EKNKSTEVDSPIVLKCELSDATSEVLWCKDGRELAPNPELNFQKDENTRKIKVESAK 1456

  Fly  1316 LAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRK---AVGTGLVLECLAVGN 1377
            |::...|...|...|         |..:..:...|.|.::..::.|.   ..|..::|:| .:.:
Zfish  1457 LSDTGNYTCHVQGDT---------VSFKVDDQAHPVRFSALPEIARNKFIEAGCPIILQC-EISD 1511

  Fly  1378 PTPRARWLTRDRPVTFSPFYEVTNEGNLK---IHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMK 1439
            ||.:..||.....:......::.:||.::   ||..|...||.|:|.|.:    |.|.::|....
Zfish  1512 PTAQVSWLKDGVELQQQSGLDIQSEGTMRKMIIHSAELKHSGVYSCEAVD----DLIAFKVDVAA 1572

  Fly  1440 PPSAPQIIVQYASADSIRVSWDAPDD---------GGAPLQGYTISYHTAGESWSITELLPENNA 1495
            ||    :...|...|.:..:....|:         ..|..|.|.........|..:.|:  ||:.
Zfish  1573 PP----VTFAYIPEDDLHRNIVEQDNILLHCQVSRSDATAQWYKDGVELKSTSNVLIEV--ENDI 1631

  Fly  1496 FTISGLKCGNQYIIKMSAH--------NMVGSGVASEEINV------------------------ 1528
                      :.:|.:|||        ...|......::||
Zfish  1632 ----------RRLIILSAHLSDSGTYTCRAGDSALVFKVNVREPPVMIVYPKEDVHLDRHVPEEI 1686

  Fly  1529 --------------WTKGKASQAPNANELIATNATCVNLKL--SSWQNGG---CS------IHHF 1568
                          |.|.......:.|..:.|......||:  |..::.|   |.      ..:.
Zfish  1687 VLSCELSRPNGKVTWFKDGQKLQESENIKLKTEGPYRRLKILHSGIEDSGEYVCDTADDSIFFNL 1751

  Fly  1569 SIEHRPLGDIRWTVVT---SDISNAEENRENLIF-CDF----LPAKWYQLRISATNDAGKTTEHY 1625
            :|:..|:     .:|:   |.:...::..|.::. |:.    ...:||:        .|...|..
Zfish  1752 NIKEPPV-----RIVSPSQSQMELCQQTSERMVLSCEISRPNATVRWYR--------DGLEVEES 1803

  Fly  1626 HFSTTNIDGI----TIPPPSVFPS-------ENDLMNNLINSTNP 1659
            ......:||:    .||.|:|..|       .:|.:...:|...|
Zfish  1804 DSLILEVDGVYRRLIIPKPTVKDSAEYVCDTTDDSVTFFVNIAEP 1848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	30/95 (32%)
		Ig	264..334	CDD:143165	21/74 (28%)
		I-set	345..433	CDD:254352	23/95 (24%)
		Ig	358..431	CDD:143165	19/75 (25%)
		Ig	456..533	CDD:143165	13/76 (17%)
		IGc2	553..619	CDD:197706	32/232 (14%)
		I-set	634..724	CDD:254352	21/97 (22%)
		ig	645..712	CDD:278476	15/66 (23%)
		IG_like	734..815	CDD:214653	18/89 (20%)
		Ig	745..815	CDD:299845	15/73 (21%)
		I-set	820..913	CDD:254352	23/109 (21%)
		Ig	838..920	CDD:299845	21/99 (21%)
		FN3	917..1033	CDD:238020	26/138 (19%)
		FN3	1040..1142	CDD:238020	25/129 (19%)
		fn3	1150..1237	CDD:278470	21/129 (16%)
		FN3	1263..1345	CDD:238020	19/94 (20%)
		Ig	1350..1436	CDD:299845	22/91 (24%)
		IG_like	1358..1436	CDD:214653	20/83 (24%)
		FN3	1441..1530	CDD:238020	18/143 (13%)
		FN3	1542..1620	CDD:238020	14/96 (15%)
obsl1b	XP_021334748.1	I-set	8..97	CDD:254352	27/88 (31%)
		I-set	112..205	CDD:254352	30/95 (32%)
		I-set	257..337	CDD:254352	22/85 (26%)
		I-set	343..413	CDD:333254	13/78 (17%)
		I-set	434..>497	CDD:333254	4/62 (6%)
		FN3	522..606	CDD:238020	14/87 (16%)
		I-set	622..>687	CDD:333254	11/64 (17%)
		Ig	720..>784	CDD:325142	14/65 (22%)
		Ig	819..889	CDD:325142	18/78 (23%)
		Ig_3	908..967	CDD:316449	16/73 (22%)
		Ig	1004..1059	CDD:319273	13/69 (19%)
		Ig	1319..1387	CDD:319273	12/68 (18%)
		Ig	1411..1468	CDD:319273	11/56 (20%)
		Ig	1503..1559	CDD:319273	15/56 (27%)
		I-set	1589..1655	CDD:333254	13/77 (17%)
		I-set	1684..1740	CDD:333254	8/55 (15%)
		Ig	1779..>1832	CDD:319273	12/60 (20%)
		IG_like	1862..1932	CDD:214653
		IG_like	1960..2030	CDD:214653
		IG	2051..2121	CDD:214652
		IG	2136..2211	CDD:214652
		I-set	2217..2298	CDD:333254
		I-set	2307..2390	CDD:333254
		I-set	2397..2466	CDD:333254
		I-set	2485..2559	CDD:333254
		I-set	2574..2655	CDD:333254
		I-set	2663..2746	CDD:333254
		I-set	2753..2835	CDD:333254
		I-set	2842..2925	CDD:333254
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910