DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and DSCAML1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens

Alignment Length:	2142	Identity:	628/2142 - (29%)
Similarity:	941/2142 - (43%)	Gaps:	280/2142 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 FLLEPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQY 104
            |:.:...::.|.:..|..|.|.|.|||...:.|.|..|.....||.:|.:..||||...||....
Human    27 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSA 91

  Fly   105 YRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYV 169
            :.:.:|:..|.|.|.|.||.:.|.|::|.||.|..:.|.||:.....||.|:.||.||..|:.||
Human    92 FNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYV 156

  Fly   170 RVASWHRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVM 234
            .|.||.:....::|:     .|:.: ...|.||:..|:.||.|..:.|:..:..:||.::|:...
Human   157 SVVSWEKDTVSIIPE-----HRFFI-TYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGAR 215

  Fly   235 LQVKELSKNLAPRTTQKPVMEI----------HVERGNDVHLPCNIQGNPFPIFTWYRVSDSAAL 289
            |.|..|::...|.....|...|          .|..|:.|.|||...|.|.|...|  :.|..
Human   216 LSVTGLARAADPLCLPDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRW--LKDGR-- 276

  Fly   290 YPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNS 354
             |:|:..|.....|.|.|.:....|:|.:||:.:|.||.......|.|...:.|.:.|:......
Human   277 -PLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI 340

  Fly   355 GGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLV 419
            |.|...:|..|||....|.|..|.:.:..:.|:     :||.||..:||:.:..:...|.|||..
Human   341 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAI-----SIRGLSNETLLITSAQKSHSGAYQCFA 400

  Fly   420 ENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSL 484
            ..:..:||..|.:.|.|..|.::.:|.|:.|.||...||.|:|.|:|||...|.||.:||:....
Human   401 TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGS 465

  Fly   485 HHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIK 549
            |.   ..|:....|..|||:|::..:..|||:|:|.|.|.:||.::.||:||.|||.:||:..|.
Human   466 HR---TNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSIRAMRNIT 527

  Fly   550 AVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIV 614
            ||||.|.:::|...|||...|:|.| ...|...||.::  |.:.|.|.:.:|:.|.|:|.|.|.|
Human   528 AVAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQV--VFENGTLKLTDVQKGMDEGEYLCSV 589

  Fly   615 RSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL 679
            ..:......:.:.:.|..||:|:||:||. ...|....|.|.||||||||..:|:||...|.|..
Human   590 LIQPQLSISQSVHVAVKVPPLIQPFEFPP-ASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGS 653

  Fly   680 QITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNT 744
            .:|.:.:||.|.|....:|.:|:|.|||.||||||.|:...:|.|||.||:..:|.:...:.|..
Human   654 GVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKA 718

  Fly   745 ISINCEAEGYPIPTITWFKGQGKGS-KDFKPLSMR-------NHSLLLNLATDNDEGYYMCQATN 801
            ..:||..:|||.|.:.|...:|.|: :.:.|:.:.       |.|||:....:.|.|||:|||:|
Human   719 GVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 783

  Fly   802 EIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNN-FR 865
            .:|..:.|::.:.|..||..........:.:.....|:|.|:|:.||.|.|.:.:..||.:. .|
Human   784 GVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMR 848

  Fly   866 FSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGS 930
            ::||.......|.|.|.:..:||.||..:.|.|.|.||....:|.|.|||.|| |..|||.||.:
Human   849 YAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPD-PPELEIREVKA 912

  Fly   931 RTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDL 995
            |::.|.|.:.|||||.:..:.::|:.          .:...|:.....|:| |:.:
Human   913 RSMNLRWTQRFDGNSIITGFDIEYKN----------KSDSWDFKQSTRNIS-PTIN--------- 957

  Fly   996 RESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQ 1060
              .|.:..|.||:.:.|||.:.|:|.||..::.:.:.|:|.||...|.:|.:|......:.|||:
Human   958 --QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWK 1020

  Fly  1061 IPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKA---TLRGLRKYSRYAVT 1122
            .|.:|..||.:.||.:...|...        .|:.:.:||...||..:   ||..|:|:::|.|.
Human  1021 APKKELQNGVIRGYQIGYRENSP--------GSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVV 1077

  Fly  1123 IRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILY 1187
            ::|.|..|:||.|:.|..||.|.||...|:||...:::|....|||.|||.....|:::||::::
Human  1078 VQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIF 1142

  Fly  1188 RPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAP 1252
            ..:....:: .:::...|:.....|..:.|.:|||::|||||..|||:.|..|:.||.:|||..|
Human  1143 WSLYVDGEW-GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPP 1206

  Fly  1253 AAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLA 1317
            |.|||...:|.|:::|||.|...||:|..||::....|....|.:......|.   :.:....|.
Human  1207 AGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQ---LFYRIAHLN 1268

  Fly  1318 ENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRA 1382
            ..|.|..||:|.||.|.|..:..:......:|||:|.|||..|.......:.|.|.:||:|.|..
Human  1269 RGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAV 1333

  Fly  1383 RWLTRDR-----PVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPS 1442
            :| |:|.     ||:......:...|.|.:..|:...||.|||||.|..|.|.|...::...||.
Human  1334 KW-TKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPD 1397

  Fly  1443 APQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHT-AGESWSITELLPENNAFTISGLKCGNQ 1506
            .|::.|...||.||.::|...|:||:.::|:.:.|.. ..|.|....:.....:|.:..||||..
Human  1398 QPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTW 1462

  Fly  1507 YIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIA-TNATCVNLKLSSWQNGGCSIHHFSI 1570
            |.:|::|.|.||||..||.|...|.|:.........|.. .|:|...|.|..|.||||.|....:
Human  1463 YKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVL 1527

  Fly  1571 EHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGI 1635
            |:||.|...|..:.::.|.      .:...:...|.||:||:.|.|.||...|...|:|.:.||.
Human  1528 EYRPKGTWAWQGLRANSSG------EVFLTELREATWYELRMRACNSAGCGNETAQFATLDYDGS 1586

  Fly  1636 TIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITV---------------SIITIALTI 1685
            ||||......|.|.:..|.....|..   .|||.|.::..|               ..:...|..
Human  1587 TIPPIKSAQGEGDDVKKLFTIGCPVI---LATLGVALLFIVRKKRKEKRLKRLRDAKSLAEMLIS 1648

  Fly  1686 KHRRTLCGPI-------------------AEGYESRTLPGDYK-------EDHENRRNQQVYSAS 1724
            |:.|:...|:                   .|..|.....||.|       .:.....|.|.:...
Human  1649 KNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQLGDDKATIPVTDAEFSQAVNPQSFCTG 1713

  Fly  1725 -----PVKTVDKGNESEMYEISP-------------YAT---FSVNGGRTGAPAKTPTRAVAAQT 1768
                 |......|...:|.:|.|             ::|   :|.....|...|.||.|.:
Human  1714 VSLHHPTLIQSTGPLIDMSDIRPGTNPVSRKNVKSAHSTRNRYSSQWTLTKCQASTPARTL---- 1774

  Fly  1769 PLDYTMQFKTFGHPEGENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTED-----ESTLSKSMT 1828
                |..::|.|...|..                |....|:......:|:.     .||.|.|.|
Human  1775 ----TSDWRTVGSQHGVT----------------VTESDSYSASLSQDTDKGRNSMVSTESASST 1819

  Fly  1829 IVAGSQA-GHSKKSNGGRSAK------------SSAACSGVVAGSESDTSIS-PS---------- 1869
            ....::| .|:|.....:.||            |....:|....::|.||:| ||
Human  1820 YEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPGICRFTAS 1884

  Fly  1870 -----------------------TEFSNMPTYRVPCKSSRSSDGRAVVDMFRPDSSTESN----- 1906
                                   :::.|:|.|.......|.:|||....:..|..::..|
Human  1885 PPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTY 1949

  Fly  1907 ------------------NDQGSPAPERRHNTPRHVLGMGMAMGLGGGGGGGVGGGNGPAEKRSA 1953
                              ...|:||.......|:..|    ||.....|......|..|||..:|
Human  1950 HTQARHLTLDPASKSLGLPHPGAPAAASTATLPQRTL----AMPAPPAGTAPPAPGPTPAEPPTA 2010

  Fly  1954 GQRSRKHGSAAQQPSNQTLERRKCPGSSNSLDSEVDAETAASLAASIAAMAGSGAGADLSGG 2015
                   .|||  |...:.|..:..|....:....|         |:..|:.||.|.....|
Human  2011 -------PSAA--PPAPSTEPPRAGGPHTKMGGSRD---------SLLEMSTSGVGRSQKQG 2054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	27/76 (36%)
		Ig	56..125	CDD:143165	25/68 (37%)
		I-set	246..337	CDD:254352	28/100 (28%)
		Ig	264..334	CDD:143165	22/69 (32%)
		I-set	345..433	CDD:254352	24/87 (28%)
		Ig	358..431	CDD:143165	20/72 (28%)
		Ig	456..533	CDD:143165	29/76 (38%)
		IGc2	553..619	CDD:197706	22/65 (34%)
		I-set	634..724	CDD:254352	41/89 (46%)
		ig	645..712	CDD:278476	29/66 (44%)
		IG_like	734..815	CDD:214653	26/88 (30%)
		Ig	745..815	CDD:299845	24/77 (31%)
		I-set	820..913	CDD:254352	27/93 (29%)
		Ig	838..920	CDD:299845	32/82 (39%)
		FN3	917..1033	CDD:238020	32/115 (28%)
		FN3	1040..1142	CDD:238020	31/104 (30%)
		fn3	1150..1237	CDD:278470	27/86 (31%)
		FN3	1263..1345	CDD:238020	23/81 (28%)
		Ig	1350..1436	CDD:299845	32/90 (36%)
		IG_like	1358..1436	CDD:214653	26/82 (32%)
		FN3	1441..1530	CDD:238020	31/89 (35%)
		FN3	1542..1620	CDD:238020	25/78 (32%)
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653	27/75 (36%)
		IGc2	43..110	CDD:197706	23/66 (35%)
		Ig	125..218	CDD:299845	30/98 (31%)
		IG_like	137..209	CDD:214653	25/77 (32%)
		I-set	245..323	CDD:254352	25/82 (30%)
		IGc2	252..313	CDD:197706	21/65 (32%)
		IGc2	340..401	CDD:197706	20/65 (31%)
		I-set	420..514	CDD:254352	37/96 (39%)
		Ig	420..510	CDD:299845	35/92 (38%)
		IGc2	531..589	CDD:197706	21/60 (35%)
		IG_like	619..698	CDD:214653	35/78 (45%)
		Ig	627..693	CDD:143165	33/65 (51%)
		I-set	702..797	CDD:254352	28/94 (30%)
		Ig7_DSCAM	719..797	CDD:143211	24/77 (31%)
		I-set	803..896	CDD:254352	27/92 (29%)
		Ig	815..903	CDD:299845	32/88 (36%)
		FN3	899..993	CDD:238020	32/116 (28%)
		FN3	1000..1097	CDD:238020	31/104 (30%)
		fn3	1105..1191	CDD:278470	27/86 (31%)
		FN3	1203..1294	CDD:238020	30/93 (32%)
		IGc2	1318..1382	CDD:197706	22/64 (34%)
		FN3	1396..1486	CDD:238020	31/89 (35%)
		FN3	1500..1572	CDD:238020	25/77 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4888
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8541
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830