DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and obscnb

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_021326058.1	Gene:	obscnb / 572412	ZFINID:	ZDB-GENE-070119-5	Length:	6781	Species:	Danio rerio

Alignment Length:	2260	Identity:	460/2260 - (20%)
Similarity:	746/2260 - (33%)	Gaps:	643/2260 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GNDTGAQVT-CTAHGSPPPLVTW-----VLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDV 109
            |...|..|| |.....|...|||     |:..|...:    ::::..:..|..         |||
Zfish  3658 GIQEGDSVTLCCELSKPGVPVTWRKETQVIHSGGKYS----IKQVGSSVELKI---------TDV 3709

  Fly   110 ---HEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRV 171
               ....|.|....   ::.:.|::|.| :...|...::|.....|.|...:|   |..:|.:.|
Zfish  3710 KPEDAGDYGCDCGE---SITTANIRVDA-LPAIFTQALKNQTAVEGESISFQC---ELSKPDIPV 3767

  Fly   172 ASWHRGEEILLPDLSDVAGRYVVLAASG---DLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAV 233
             .|.|||..|.|     ..:| .|...|   .|.:.::..||. ..:.|       ..|.|....
Zfish  3768 -EWRRGEIGLCP-----CAKY-ELKQHGHHAQLIIHNLEPEDS-GDYIC-------DTRDRQSVA 3817

  Fly   234 MLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTW---YRVSDSAALYPIPSS 295
            .|:||.|     |...:..:.::..|.|.:....|.:..:...:. |   .||.:::..|.:...
Zfish  3818 YLEVKAL-----PVLFKSFLKDLETETGENAVFRCELAKSGAKVI-WRKNKRVIEASNKYQLKQD 3876

  Fly   296 QRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQ--IVNSGGTA 358
            ..|    ..|::....|.|.|::.|:..:    .:...:|:|.. ..:.||..::  |||.|...
Zfish  3877 GAV----AELIVYKLQEGDCGEYSCETEH----DQTSAKLTVKE-PEITILTGLKSCIVNEGEDV 3932

  Fly   359 NFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGV--------- 414
            :|.|..:......:.|.....|||.|.....|.:.    .:.:|.:::|.::|.|.
Zfish  3933 HFECLVSHDNAVIVQWTLQDVPLQNNEMNKIGMEG----KRHTLTLRSVTQKDSGTLSFHVGAHT 3993

  Fly   415 -YQCLVENQRASAQAMAELKLGDTVPELIYT--FIEQNVRPGPLISLKCSASGSPPPQFAWLLDS 476
             :.||...               .:|.|.:|  ...|.|..|...||:|..| .|.....|..::
Zfish  3994 SFACLTVR---------------AIPVLSFTKELTSQEVTEGGSTSLRCETS-IPDASVTWKKNT 4042

  Fly   477 QPIMDVSLHHRFAIGQFVDMSGDVISH-LNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYG-P 539
            ..:.|         |:...:..|...| |.|..:..:|.|.|.|.|    |..:..|.|.|.. .
Zfish  4043 LVLTD---------GKKYSIKRDGTIHILEIHKLSVEDAGEYTCEA----GEKKSKATLTVKECV 4094

  Fly   540 PYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPG 604
            ...|.:..:..:.|||.|..|..:...|..:.|......|..::..:::.......||:|.|.|.
Zfish  4095 KITRELKDVTVITGEDAIFQCEVSQKGVTNVEWWLGSNHLQNNDLNQISCQGREHSLVLKMVTPD 4159

  Fly   605 RDQGIYTCIV---RSRAGEEARRDMQLNVNSPPVIEPFKFPKNL--QEGGRAQITCAVSSGDMPI 664
             |.|....:|   :|.|        .|.|...|.:...:.|.::  :||....::|..|..:..:
Zfish  4160 -DSGDVAFVVGPMKSVA--------YLMVQEKPKVVFLEKPLDITAKEGQTVTLSCMTSDPEAAV 4215

  Fly   665 YFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPR 729
              :|.||:..|.:..:....|:.....|....:....:|.|||...:|.:    .|.|.|:..|.
Zfish  4216 --AWYKDEEMIKAGGRYLLYKDRAVHQLRILRVEEGDAGLYTCKTKDAES----CATLTVKGQPA 4274

  Fly   730 W-RYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDN--- 790
            : |.|..:...:.|::|.:.||. ..|:.::.|.|| |...:..|...::....:|.|...:
Zfish  4275 YFRKELENQNAIEGDSIILRCEL-SKPVKSVEWRKG-GVVLQPSKKFELKQDGCVLELHVHDLEP 4337

  Fly   791 -DEGYYMCQATNE--------------IGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDC 840
             |.|||.|.|.::              |.:|:|.| .:.|.|.|.|....    |||
Zfish  4338 EDNGYYTCDAGDQLTTASITVQEAEVLIVSGIKNT-DVFVGEQAVFSCQL----SRR-------- 4389

  Fly   841 HAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVD--SQLTIGHSDRHDSGVY--------- 894
             |||    .:.|..:..|  |.|..||...|    |.|  ..||:.:...:|||..
Zfish  4390 -AKG----RVQWWLDGTR--LENSTFSEISM----GEDHVHTLTLRNLSPNDSGTVLFKTGALTS 4443

  Fly   895 --RCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQAL 957
              :.:.::|   ..:::.....:........|.....||.||..|:|   ...||
Zfish  4444 SAKLLVKDP---NVEVVSAMEDQHVAEKQPAEFICQYSRPVKAIWKR---NGVPV---------- 4492

  Fly   958 KYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIER 1022
               |:.|.......||....:.:|.........|..:...:::||.|......:..:|.::.:|.
Zfish  4493 ---QADGRRVIMEQDWTVARLYISCVEPQDGGIYSCEAEGTSVVAHLRVQAKPIDILQELSNMET 4554

  Fly  1023 SAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQI---PPRESWNGELIGYTVNCSEEKQN 1084
            ....||:.     |.....|.|...|          |.|   |.:||.|.|::.:    ...:::
Zfish  4555 INGGEALF-----ECSLSRPENKDCQ----------WLIDGKPVKESANVEIVSF----ESGRRH 4600

  Fly  1085 INFISVVN--SSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPW----------SAA 1137
            :..:..:.  .:.:.|..:|.::|.|.|           |::|        |          ..|
Zfish  4601 LLLLKDLQPCENTRITFQAGTSSTTALL-----------TVKA--------WQLEVVKPLEDKTA 4646

  Fly  1138 IFGTTAE---GVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAK 1199
            |.|...|   .:.||.|:|           :::|      :..|:         .:.|...:
Zfish  4647 IVGQEVEFTCTLNEAVPEN-----------EVTW------YANGV---------ELQHNDQW--- 4682

  Fly  1200 LEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADS 1264
              ..|||. .:|...|.||.....:.:.:.|. |.|:...|   |...|||.|...:..:.....
Zfish  4683 --AMRTSG-SSYSLILKKAQAQPTQEITFAAR-DALSLAKL---TTIAVPDPPEDPELVSKGPTF 4740

  Fly  1265 ILISWLTPKNRNG--IISHYTVYSREAGRKGQAKTHMVRVDE------NGYPVTFESRSLAENQM 1321
            |.:||.||.:..|  ||.:              :..|..||.      :..|| |.:..|.||.:
Zfish  4741 ITLSWFTPLSDGGSPIIGY--------------RVEMRLVDSVLWLPCHTEPV-FNTEFLVENLI 4790

  Fly  1322 ----YEFWVSASTSVGEGEPTSVIAQATNTRAPARIAS--------FGQVVRKAVGTGLVLEC-- 1372
                |.|.|:|....|.|||.. :.|.....||..:..        .|::||        |||
Zfish  4791 PGAGYRFRVAAINRAGIGEPVQ-LPQTVTLDAPVTMTKKLSTSELHKGKMVR--------LECEL 4846

  Fly  1373 LAVGNPTPRARWLTRDRPVTFSPFYEVTNEGN---LKIHRVEGSLSGNYTCTAN---------NL 1425
            .|.|.   ...|...:|.:.....|::..||.   |.|...:.:..|.|:|:|:         ||
Zfish  4847 SAEGK---SVAWFKDNREIEVGVKYQMVTEGKSQVLLIKDFQTTDQGVYSCSASEEAKTSINLNL 4908

  Fly  1426 FGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDA-------------------PDDGG---- 1467
            .|.|....|....:|...|:.    ||...:...|:|                   |::.|
Zfish  4909 EGHDGTLSQDAGNQPKLPPEA----ASEGDLHALWEAEAKKRRMSREPTLDSISELPEEDGKDKM 4969

  Fly  1468 ------APLQGYTISYHTAGESWSITELLPENNAFT------ISGLKCGNQYIIKMSAHNMVGSG 1520
                  .|.:...:.....|     .::..|.|.:|      :||....: |:.|.|..:|....
Zfish  4970 QKKDEKEPAKEIKVRPVEPG-----PKITAEPNLYTSSDEESLSGTSLVS-YLKKSSKSSMTVES 5028

  Fly  1521 ----VASEEI--------NVWTKGKAS---QAPNANELIATNATCVNLKLSSWQNGGCSIHHFSI 1570
                |||:::        ...||....   :|.|.:||               |.....|.....
Zfish  5029 QTETVASKKLYEHFQMTEQSVTKTSVEPLMEAQNGDEL---------------QEAAVKIQAAFK 5078

  Fly  1571 EHRPLGDIRWTVVTSDISNAEENREN-LIFCDFL----PAKWYQLRISATNDAGKTTEHYHFSTT 1630
            .::...|:|  .|..::...:....| .|..:.:    |.|...|:.......||   |:|....
Zfish  5079 GYKARKDMR--PVFKEVFKEQTKEPNGTIHLECIVEGKPDKVRWLKDGEPLTDGK---HHHIDIY 5138

  Fly  1631 N-------IDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHR 1688
            |       :...|.....|:..|  :.|....||:  ||.          :||..:        |
Zfish  5139 NDGTCSLVVTAATTKDTGVYTCE--VTNKFGVSTH--SGK----------VTVGSL--------R 5181

  Fly  1689 RTLCGPIAEGYES---------------------------RT-LPGD------------------ 1707
            .::..|:..||.:                           || ||.|
Zfish  5182 ESVRRPLTLGYSADSEAESSSGSEMDETLRQASKRLRRLLRTRLPPDVEEEPFVSADEGDLPPQD 5246

  Fly  1708 ---YKED-------HENRRNQQV----------YSASPVKTV---DKGNESEMYEISPYATFSVN 1749
               |:||       .:||...||          |...|::|.   ..|.:.|: .|:..| .|.:
Zfish  5247 LQSYREDDQYIYIRFDNRTEAQVASLRFQEMFTYQGVPIETAIIPAAGAKVEL-RITKMA-LSED 5309

  Fly  1750 GGRTGAPAK---TPTRAVAAQTPLDYTMQFKTFGHPEGENLNATAYPLLPSSGF-----GHVKSK 1806
            |.||  |.:   .||....|.....:..:.::...|:|       :|:    .|     |.....
Zfish  5310 GSRT--PTQDQPMPTFMTGAPAAPVFMTELRSQDVPDG-------FPV----SFDCVIVGKPPPT 5361

  Fly  1807 SSWHK-------QRYY--NTEDESTLSKSMTIVAGSQAG----HSKKSNGGRSAKS----SAACS 1854
            ..|.|       ..:|  |.:.|......:|.|..:..|    .::..:|..|:|:    ..:||
Zfish  5362 VKWFKDGKLLEENDHYMINEDQEGRHQLIITTVLPTDMGVYRCMAENDSGIASSKAELRVDMSCS 5426

  Fly  1855 GVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDGRA----VVDMFRPDSSTESNNDQGSPAPE 1915
                 |:.||: :.:||.|:..:.:....||...|..|    ..|...|....|.::...||
Zfish  5427 -----SDYDTA-ADATETSSYVSAKGYVSSSEHRDTEAFESVAEDELLPQVVDELHDLFLSP--- 5482

  Fly  1916 RRHNTPRHVLGMGMAMGLGGGGGGGVGGGNGPAEKRSAGQRS--------RKHGSAAQQPSNQTL 1972
                                         ..|..|.|...:.        .|.|:..|..|...|
Zfish  5483 -----------------------------GAPIAKMSVRVKGFPTPRVYWFKDGTPLQASSRIVL 5518

  Fly  1973 ERRKCPGSSNSLDSEVDAETAASLAASIAAMAGSGAGAD----LSGGFRP 2018
            ...:...|...||  |..|.....:|.|:.:|||...:.    |:.|.||
Zfish  5519 STERDQHSLEILD--VKCEDTGEYSAYISNIAGSAYSSARMNVLAPGERP 5566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	16/85 (19%)
		Ig	56..125	CDD:143165	15/77 (19%)
		I-set	246..337	CDD:254352	15/93 (16%)
		Ig	264..334	CDD:143165	11/72 (15%)
		I-set	345..433	CDD:254352	20/99 (20%)
		Ig	358..431	CDD:143165	14/82 (17%)
		Ig	456..533	CDD:143165	18/77 (23%)
		IGc2	553..619	CDD:197706	17/68 (25%)
		I-set	634..724	CDD:254352	19/91 (21%)
		ig	645..712	CDD:278476	14/68 (21%)
		IG_like	734..815	CDD:214653	22/98 (22%)
		Ig	745..815	CDD:299845	21/87 (24%)
		I-set	820..913	CDD:254352	22/105 (21%)
		Ig	838..920	CDD:299845	18/94 (19%)
		FN3	917..1033	CDD:238020	22/115 (19%)
		FN3	1040..1142	CDD:238020	21/116 (18%)
		fn3	1150..1237	CDD:278470	15/86 (17%)
		FN3	1263..1345	CDD:238020	26/93 (28%)
		Ig	1350..1436	CDD:299845	25/107 (23%)
		IG_like	1358..1436	CDD:214653	23/91 (25%)
		FN3	1441..1530	CDD:238020	21/135 (16%)
		FN3	1542..1620	CDD:238020	12/82 (15%)
obscnb	XP_021326058.1	I-set	10..99	CDD:254352
		I-set	110..199	CDD:254352
		I-set	282..362	CDD:333254
		I-set	369..452	CDD:333254
		I-set	459..>523	CDD:333254
		FN3	547..634	CDD:238020
		Ig	762..809	CDD:319273
		IG	836..901	CDD:214652
		I-set	928..997	CDD:333254
		I-set	1020..1089	CDD:333254
		I-set	1112..1181	CDD:333254
		I-set	1204..1273	CDD:333254
		I-set	1296..1365	CDD:333254
		Ig	1401..1469	CDD:319273
		I-set	1483..1552	CDD:333254
		Ig	1585..1644	CDD:319273
		Ig	1689..1732	CDD:319273
		I-set	1750..1833	CDD:333254
		I-set	1840..1923	CDD:254352
		I-set	1930..1999	CDD:333254
		I-set	2018..2091	CDD:333254
		I-set	2107..2190	CDD:333254
		I-set	2196..2279	CDD:333254
		I-set	2285..2368	CDD:333254
		I-set	2374..2458	CDD:333254
		I-set	2464..2547	CDD:333254
		I-set	2553..>2620	CDD:333254
		I-set	2643..2725	CDD:333254
		I-set	2732..2815	CDD:333254
		I-set	2820..2905	CDD:333254
		I-set	2912..2995	CDD:333254
		IG_like	3007..3084	CDD:214653
		I-set	3090..3160	CDD:333254
		I-set	3178..3260	CDD:333254
		I-set	3266..3349	CDD:333254
		IG_like	3389..>3452	CDD:214653
		I-set	3471..3541	CDD:333254
		I-set	3560..3630	CDD:333254
		I-set	3649..3719	CDD:333254	16/73 (22%)
		I-set	3739..3808	CDD:333254	20/79 (25%)
		I-set	3828..3910	CDD:333254	14/90 (16%)
		IG	3926..4000	CDD:214652	17/77 (22%)
		I-set	4007..4090	CDD:254352	24/96 (25%)
		I-set	4095..>4162	CDD:333254	15/67 (22%)
		I-set	4186..4269	CDD:254352	18/88 (20%)
		I-set	4275..4358	CDD:333254	20/84 (24%)
		IG	4370..4449	CDD:214652	26/102 (25%)
		IG_like	4461..4538	CDD:214653	18/92 (20%)
		I-set	4636..>4700	CDD:333254	18/95 (19%)
		FN3	4725..4818	CDD:238020	29/108 (27%)
		I-set	4825..4906	CDD:333254	19/91 (21%)
		IQ	5065..5087	CDD:197470	5/36 (14%)
		I-set	5104..5177	CDD:254352	17/89 (19%)
		I-set	5331..5421	CDD:254352	16/100 (16%)
		I-set	5469..5559	CDD:254352	22/123 (18%)
		I-set	5583..5678	CDD:333254
		SH3_Obscurin_like	5807..5869	CDD:212958
		RhoGEF	5899..6075	CDD:321997
		PH_Obscurin	6084..6208	CDD:270059
		I-set	6216..6308	CDD:254352
		I-set	6310..6399	CDD:333254
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910